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9-keto Fluprostenol isopropyl ester

CAS No.
1219032-18-4
Chemical Name:
9-keto Fluprostenol isopropyl ester
Synonyms
Travoprost 12;9-ketotrevoprost;9-Keto Travoprost;Travoprost Impurity 21;Travoprost Impurity 35;9-KETO FLUPROSTENOL ISOPROPYL ESTER;FLUPROSTENOL PROSTAGLANDIN E2 ISOPROPYL ESTER;Travoprost Impurity 16(9-keto Fluprostenol Isopropyl Ester);(+)-9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC-ACID, ISOPROPYL ESTER;5-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-5-oxocyclopentyl]-, 1-methylethyl ester, (5Z)-
CBNumber:
CB1143711
Molecular Formula:
C26H33F3O6
Molecular Weight:
498.53
MDL Number:
MFCD02259341
MOL File:
Mol file
MSDS File:
SDS
Last updated:2026-05-27 23:08:56
Product description Number Pack Size Price
9-keto Fluprostenol isopropyl ester ≥98% 16782 1mg $97
9-keto Fluprostenol isopropyl ester ≥98% 16782 5mg $428
9-keto Fluprostenol isopropyl ester ≥98% 16782 10mg $761
9-keto Fluprostenol isopropyl ester ≥98% 16782 1mg $88
9-keto Fluprostenol isopropyl ester ≥98% 16782 5mg $389
More product size

9-keto Fluprostenol isopropyl ester Properties

Boiling point 583.6±50.0 °C(Predicted)
Density 1.241±0.06 g/cm3(Predicted)
solubility DMF: 30 mg/ml; DMF:PBS (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml
pka 13.32±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319
Precautionary statements  P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
NFPA 704
3
2 0

9-keto Fluprostenol isopropyl ester price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16782 9-keto Fluprostenol isopropyl ester ≥98% 1219032-18-4 1mg $97 2026-04-30 Buy
Cayman Chemical 16782 9-keto Fluprostenol isopropyl ester ≥98% 1219032-18-4 5mg $428 2026-04-30 Buy
Cayman Chemical 16782 9-keto Fluprostenol isopropyl ester ≥98% 1219032-18-4 10mg $761 2026-04-30 Buy
Cayman Chemical 16782 9-keto Fluprostenol isopropyl ester ≥98% 1219032-18-4 1mg $88 2024-03-01 Buy
Cayman Chemical 16782 9-keto Fluprostenol isopropyl ester ≥98% 1219032-18-4 5mg $389 2024-03-01 Buy
Product number Packaging Price Buy
16782 1mg $97 Buy
16782 5mg $428 Buy
16782 10mg $761 Buy
16782 1mg $88 Buy
16782 5mg $389 Buy

9-keto Fluprostenol isopropyl ester Chemical Properties,Uses,Production

Uses

Fluprostenol is a well-studied, potent analog of prostaglandin F2α (PGF2α) and acts primarily through the FP receptor. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations.

Uses

9-Keto Travoprost is an impurity of Travoprost (T715600), a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).

9-keto Fluprostenol isopropyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-9-OXO-11ALPHA,15R-DIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC-ACID, ISOPROPYL ESTER 9-KETO FLUPROSTENOL ISOPROPYL ESTER FLUPROSTENOL PROSTAGLANDIN E2 ISOPROPYL ESTER Travoprost Impurity 16(9-keto Fluprostenol Isopropyl Ester) 9-Keto Travoprost Travoprost Impurity 35 Travoprost Impurity 21 Travoprost 12 5-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-5-oxocyclopentyl]-, 1-methylethyl ester, (5Z)- 9-ketotrevoprost 1219032-18-4