4-Fluorobenzoic anhydride
- CAS No.
- 25569-77-1
- Chemical Name:
- 4-Fluorobenzoic anhydride
- Synonyms
- p-Fluorobenzoic anhydride;4-Fluorobenzoic anhydride;4-Fluorobenzoicanhydride,97%;Bis[p-fluorobenzoic]anhydride;(4-fluorobenzoyl) 4-fluorobenzoate;Bis(4-fluorobenzoic acid)anhydride;4-fluorobenzene-1-carboxylic anhydride 95+%;4-Fluorobenzoic acid anhydride with 4-fluorobenzoic acid;Benzoic acid, 4-fluoro-, anhydride with 4-fluorobenzoic acid
- CBNumber:
- CB11449922
- Molecular Formula:
- C14H8F2O3
- Molecular Weight:
- 262.21
- MDL Number:
- MFCD00425938
- MOL File:
- 25569-77-1.mol
- MSDS File:
- SDS
| Melting point | 107-108℃ |
|---|---|
| Boiling point | 382.8±27.0 °C(Predicted) |
| Density | 1.343 |
| storage temp. | Inert atmosphere,Room Temperature |
| Appearance | White to off-white Solid |
| Water Solubility | Sparingly soluble in water.(0.26 g/L) (25°C), |
| Sensitive | Moisture Sensitive |
| CAS DataBase Reference | 25569-77-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2917399590 | |||||||||
| NFPA 704 |
|
4-Fluorobenzoic anhydride price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC31419 | 4-fluorobenzene-1-carboxylic anhydride 95% | 25569-77-1 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC31419 | 4-fluorobenzene-1-carboxylic anhydride 95% | 25569-77-1 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC31419 | 4-fluorobenzene-1-carboxylic anhydride 95% | 25569-77-1 | 5g | $69 | 2026-06-04 | Buy |
| Apolloscientific | PC31419 | 4-fluorobenzene-1-carboxylic anhydride 95% | 25569-77-1 | 25g | $331 | 2026-06-04 | Buy |
| Apolloscientific | PC31419 | 4-fluorobenzene-1-carboxylic anhydride 95% | 25569-77-1 | 100g | $1317 | 2026-06-04 | Buy |
4-Fluorobenzoic anhydride Chemical Properties, Uses, Production
Uses
It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.
Synthesis
456-22-4
25569-77-1
GENERAL METHOD: p-Fluorobenzoic acid (1 mmol) was dissolved in anhydrous CH3CN (5 mL) with K2CO3 (1.5 mmol, 0.20 g), followed by the addition of TsCl (0.5 mmol, 0.10 g). The reaction mixture was stirred at room temperature for appropriate time (20-180 min, see Table 2) until TLC detection showed complete consumption of TsCl. After completion of the reaction, CH2Cl2 or Et2O (2 × 10 mL) was added to the mixture, stirred thoroughly and filtered. The organic layer was dried with CaCl2 and the solvent was subsequently evaporated to give high purity 4-fluorobenzoic anhydride.
References
[1] Letters in Organic Chemistry, 2017, vol. 14, # 6, p. 431 - 439
[2] Bulletin of the Chemical Society of Ethiopia, 2011, vol. 25, # 2, p. 255 - 262
[3] Journal of Organic Chemistry, 1970, vol. 35, p. 3233 - 3237
[4] Journal of the American Chemical Society, 2005, vol. 127, # 44, p. 15521 - 15527
[5] Journal of Medicinal Chemistry, 2007, vol. 50, # 9, p. 2249 - 2253
4-Fluorobenzoic anhydride Preparation Products And Raw materials
4-Fluorobenzoic anhydride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
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| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
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| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20788 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from 4-Fluorobenzoic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | 4-Fluorobenzoic anhydride
25569-77-1
|
50mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
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- 4-Fluorobenzoic anhydride
25569-77-1
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
