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(S)-3-Boc-amino-2-piperidone

(S)-3-Boc-amino-2-piperidone Structure
(S)-3-Boc-amino-2-piperidone structure
CAS No.
92235-39-7
Chemical Name:
(S)-3-Boc-amino-2-piperidone
Synonyms
N-Boc L-Orinithine LactaM;3-Pyridinol,8-(aminomethyl)-;(S)-3-Boc-amino-2-piperidone;(S)-3-Boc-aminopiperidin-2-one;(S)-3-(Boc-amino)-2-oxopiperidine;(3S)-2-Oxo-3-(Boc-amino)piperidine;t-Butyl (S)-2-oxopiperidin-3-ylcarbamate;3-tert-butyloxycarbonylamino-2-piperidone;TERT-BUTYL (S)-2-OXOPIPERIDIN-3-YLCABAMATE;(S)-tert-butyl 2-oxopiperidin-3-ylcarbamate
CBNumber:
CB1146833
Molecular Formula:
C10H18N2O3
Molecular Weight:
214.26
MDL Number:
MFCD08166304
MOL File:
92235-39-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:42
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(S)-3-Boc-amino-2-piperidone Properties

Melting point 203-205 °C
Boiling point 405.6±34.0 °C(Predicted)
Density 1.11±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 11.05±0.20(Predicted)
Appearance White to off-white Solid
optical activity Consistent with structure

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990

(S)-3-Boc-amino-2-piperidone price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR913300 (3S)-3-Aminopiperidin-2-one, 3-BOC protected 97% 92235-39-7 1g $35 2026-06-04 Buy
Apolloscientific OR913300 (3S)-3-Aminopiperidin-2-one, 3-BOC protected 97% 92235-39-7 5g $90 2026-06-04 Buy
Apolloscientific OR913300 (3S)-3-Aminopiperidin-2-one, 3-BOC protected 97% 92235-39-7 10g $153 2026-06-04 Buy
Apolloscientific OR913300 (3S)-3-Aminopiperidin-2-one, 3-BOC protected 97% 92235-39-7 25g $278 2026-06-04 Buy
Apolloscientific OR913300 (3S)-3-Aminopiperidin-2-one, 3-BOC protected 97% 92235-39-7 100g $1101 2026-06-04 Buy
Product number Packaging Price Buy
OR913300 1g $35 Buy
OR913300 5g $90 Buy
OR913300 10g $153 Buy
OR913300 25g $278 Buy
OR913300 100g $1101 Buy

(S)-3-Boc-amino-2-piperidone Chemical Properties, Uses, Production

Uses

N-Boc L-Orinithine Lactam is used in the synthesis of Pro-Leu-Gly-NH2 analogs for dopamine receptor modulation.

Synthesis

BOC-ORN-OH

21887-64-9

(S)-3-BOC-AMINO-2-PIPERIDONE

92235-39-7

General procedure for the synthesis of tert-butyl (S)-2-piperidone-3-carbamate from (S)-5-amino-2-((tert-butoxycarbonyl)amino)pentanoic acid: 64 g (2.75 mmol) of BOC-L-ORN-OH was dissolved in 275 mL of DMF at 0 °C. To this solution 1.22 g (2.75 mmol) of BOP reagent and 1.16 g (20.0 mmol) of sodium bicarbonate were added. The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to about 5 mL. The concentrated mixture was diluted with 100 mL of water and saturated sodium bicarbonate solution (1:1) and subsequently extracted with three 100 mL portions of ethyl acetate (EtOAc). The organic phases were combined, washed sequentially with 300 mL of water and 300 mL of brine, dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure to afford the target product (S)-tert-butyl (S)-piperidin-2-one-3-carbamate (133) as a colorless solid in 0.37 g (62%) yield. The product was analyzed by silica gel thin layer chromatography (TLC) with an Rf value of 0.55 (unfolding agent: dichloromethane-methanol = 10:1). Nuclear magnetic resonance hydrogen spectra (1H NMR, CDCl3) showed δ 1.32 (s, 9H), 1.45-1.64 (m, 1H), 1.65-1.84 (m, 2H), 2.10-2.30 (m, 1H), 3.15-3.25 (m, 2H), 3.79-4.05 (m, 1H), 5.62 (br s, 1H) and 6.99 (br s, 1H). Nuclear magnetic resonance carbon spectra (13C NMR, CDCl3) showed δ 27.7, 28.2, 36.56, 36.61, 41.5, 51.0, 79.5, 156.0 and 172.3.

References

[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 23, p. 4531 - 4536
[2] Patent: WO2016/118877, 2016, A1. Location in patent: Paragraph 00208

(S)-3-Boc-amino-2-piperidone Preparation Products And Raw materials

Raw materials

Boc-Orn-OH Di-tert-butyl dicarbonate L(+)-Ornithine hydrochloride Sodium bicarbonate N,N-Dimethylformamide

Preparation Products

(S)-3-aminopiperidin-2-one Hydrochloride

(S)-3-Boc-amino-2-piperidone Suppliers

Global Suppliers ( 105)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Sichuan Guanghan Bio-Tech Co., Ltd +86-28-86127071 info@sino-produce.com China 400 66
Shangchem Co., Ltd. +86-21-68182121 China 881 52
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chembon Pharmaceutical Co., Ltd. 028-84252981 18583719936 sales@chembon.com.cn China 854 64
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7909 65
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Capot Chemical Co., Ltd 66
Sichuan Guanghan Bio-Tech Co., Ltd 66
Shangchem Co., Ltd. 52
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Chembon Pharmaceutical Co., Ltd. 64
Daicel Chiral Technologies (China)CO.,LTD 65

View Latest Price from (S)-3-Boc-amino-2-piperidone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-3-BOC-AMINO-2-PIPERIDONE pictures 2020-01-15 (S)-3-BOC-AMINO-2-PIPERIDONE
92235-39-7
 $1.00 1g 99% 1000KGS Career Henan Chemical Co

(S)-3-Boc-amino-2-piperidone Spectrum

(S)-3-BOC-AMINO-2-PIPERIDONE(92235-39-7)1HNMR(S)-3-BOC-AMINO-2-PIPERIDONE(92235-39-7)1HNMR

92235-39-7 ((S)-3-Boc-amino-2-piperidone) Related Search:

(S)-3-N-Boc-amino-[1,4']bipiperidinyl-2-one Boc-(5R)-indolizidin-9-one amino acid Methyl (3S,6S,8aR)-6-[(tert-butoxycarbonyl)amino]-5-oxooctahydroindolizine-3-carboxylate (S)-2-(3-(tert-Butoxycarbonylamino)-2-oxopiperidin-1-yl)aceticacid Methyl (3S,6S,8aS)-6-[(tert-butoxycarbonyl)amino]-5-oxooctahydroindolizine-3-carboxylate
(S)-3-Boc-amino-2-piperidone Boc-btd Bicyclo-[6, 5]-Boc-(2S, 3R)-Glu-(2S)-pen N-(Boc)-(3S,6S,9S)-2-oxo-3-amino-1-aza-bicyclo[4.3.0]-nonane-9-carboxylic acid

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(S)-3-Boc-aminopiperidin-2-one 3-tert-butyloxycarbonylamino-2-piperidone t-Butyl (S)-2-oxopiperidin-3-ylcarbamate N-tert-butyl-N-(2-oxopiperidin-3-yl)carbaMate tert-butyl [(3S)-2-oxopiperidin-3-yl]carbaMate (S)-tert-butyl 2-oxopiperidin-3-ylcarbamate tert-butyl N-[(3S)-2-oxopiperidin-3-yl]carbaMate N-Boc L-Orinithine LactaM N-[(3S)-2-Oxo-3-piperidinyl]carbamic Acid tert-Butyl E ster N-[(3S)-2-Oxo-3-piperidinyl]carbamic Acid tert-Butyl E ster,99%e.e. 3(S)-<(butoxycarbonyl)amino>-2-oxopiperidine TERT-BUTYL (S)-2-OXOPIPERIDIN-3-YLCABAMATE (S)-3-(Boc-amino)-2-oxopiperidine (3S)-2-Oxo-3-(Boc-amino)piperidine Carbamic acid, N-[(3S)-2-oxo-3-piperidinyl]-, 1,1-dimethylethyl ester 3-Pyridinol,8-(aminomethyl)- 1,1-Dimethylethyl?N-[(3S)-2-oxo-3-piperidinyl]carbamate tert-butyl N-[(3S)-2-oxo-3-piperidyl]carbamate (3S)-3-Aminopiperidin-2-one, 3-BOC protected (S)-tert-Butyl 3-aminopiperidin-2-one-1-carboxylate (S)-3-Boc-amino-2-piperidone 92235-39-7 pharmacetical CHIRAL CHEMICALS