Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Imiquimod 2HCl

Imiquimod 2HCl

Imiquimod 2HCl Structure
Imiquimod 2HCl structure
CAS No.
2995277-02-4
Chemical Name:
Imiquimod 2HCl
Synonyms
Imiquimod 2HCl;1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-, hydrochloride (1:2)
CBNumber:
CB114698898
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2025-12-16 21:30:20
Request For Quotation

Imiquimod 2HCl Chemical Properties,Uses,Production

Uses

Imiquimod (R 837) dihydrochloride, an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

in vivo

Imiquimod (IMQ) can be used to induce psoriasis models[5].

Induction of psoriasis Model[5]
Background
Lmiquimod (IMQ) induces inflamed scaly skin lesions resembling plaque-type psoriasis. IMQ induces epidermal expression of IL-23, IL-17A, and IL-17F, as well as an increase in splenic Th17 cells.
Specific Mmodeling Methods
Mice: BALB/c ? male ? 8-week-old
Administration: 3.125 mg/day ? skin ? 6 days
Note
IMQ cream preparation [7]:
(1) Prepare BM of lipids
STA and OA were melted at 75 °C followed by the addition of IMQ (3.5% of the BM, w/w) under continuous stirring.
Polysorbate 80 and stearoyl polyoxyl-32 glycerides at a 50:50 ratio were dispersed in water heated separately to 75 °C and added to the BM phase under continuous stirring.
(2) Prepare nanostructured lipid carriers (NLCs)
The mixture was then subjected to high-shear homogenization followed by ultrasonication.
The mixture was then rapidly cooled in an ice bath to allow the formation of NLCs.
Modeling Indicators
Behavior Observation: Induced the back skin of the mice started to display signs of erythema, scaling, and thickening.
Resulted in hyperproliferative keratinocytes and a disturbed epidermal differentiation (parakeratosis).
Correlated Product(s): /
Opposite Product(s): /

[1].

References

[1] Athina Angelopoulou, et al. Imiquimod - A toll like receptor 7 agonist - Is an ideal option for management of COVID 19. Environ Res. 2020 Sep; 188: 109858. DOI:10.1016/j.envres.2020.109858
[2] Aditya K Gupta, et al. Imiquimod: a review. J Cutan Med Surg. Nov-Dec 2002;6(6):554-60. DOI:10.1007/s10227-001-0134-6
[3] Yuji Kan, et al. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012 Oct;86(19):10338-46. DOI:10.1128/JVI.01196-12
[4] Michael P Sch?n, et al. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol. 2006 Jun;126(6):1338-47. DOI:10.1038/sj.jid.5700286
[5] Leslie van der Fits, et al. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol. 2009, 182, 9. DOI:10.4049/jimmunol.0802999
[6] Ajla Smajlovi?, et al. Molecular and histopathological profiling of imiquimod induced dermatosis in Swiss Wistar rats: contribution to the rat model for novel anti-psoriasis treatments. Mol Biol Rep. 2021, 48, 5. DOI:10.1007/s11033-021-06445-3
[7] Sangseo Kim, et al. Development and Optimization of Imiquimod-Loaded Nanostructured Lipid Carriers Using a Hybrid Design of Experiments Approach. Int J Nanomedicine. 2023. DOI:10.2147/IJN.S400610

Imiquimod 2HCl Preparation Products And Raw materials

Raw materials

Preparation Products

Imiquimod 2HCl Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32436 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19961 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29342 58
Shanghai Amole Biotechnology Co., Ltd. 18916360931 18916360931 2596183085@qq.com China 17236 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58
Shanghai Amole Biotechnology Co., Ltd. 58

View Lastest Price from Imiquimod 2HCl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Imiquimod 2HCl pictures 2025-12-16 Imiquimod 2HCl
2995277-02-4
 US $195.00-692.00 / mg 99.41% 10g TargetMol Chemicals Inc.
Imiquimod 2HCl pictures 2025-12-16 Imiquimod 2HCl
2995277-02-4
 US $195.00-692.00 / mg 99.41% 10g TargetMol Chemicals Inc.
Imiquimod 2HCl pictures 2025-05-15 Imiquimod 2HCl
2995277-02-4
 US $195.00-692.00 / mg 99.18% 10g TargetMol Chemicals Inc.
  • Imiquimod 2HCl pictures
  • Imiquimod 2HCl
    2995277-02-4
  • US $195.00-692.00 / mg
  • 99.41%
  • TargetMol Chemicals Inc.
  • Imiquimod 2HCl pictures
  • Imiquimod 2HCl
    2995277-02-4
  • US $195.00-692.00 / mg
  • 99.41%
  • TargetMol Chemicals Inc.
  • Imiquimod 2HCl pictures
  • Imiquimod 2HCl
    2995277-02-4
  • US $195.00-692.00 / mg
  • 99.18%
  • TargetMol Chemicals Inc.

Imiquimod 2HCl Spectrum

Imiquimod 2HCl(2995277-02-4)1HNMR
Imiquimod 2HCl 1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)-, hydrochloride (1:2) 2995277-02-4