6-OH-BTA-1
- CAS No.
- 566169-93-5
- Chemical Name:
- 6-OH-BTA-1
- Synonyms
- Pittsburgh Compound-B;2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol;6-OH-BTA-1;PiB, 10 mM in DMSO;6-OH-BTA-1 (free base);6-OH-BTA-1(free base)566169-93-5;2-[4-(Methylamino)-phenyl]-6-benzothiazolol;6-Benzothiazolol, 2-[4-(methylamino)phenyl]-;2-[4-(Methylamino)phenyl]-1,3-benzothiazol-6-ol;2-[4''-(Methylamino)phenyl]-6-hydroxybenzothiazole
- CBNumber:
- CB11484156
- Molecular Formula:
- C14H12N2OS
- Molecular Weight:
- 256.32288
- MDL Number:
- MFCD17018727
- MOL File:
- 566169-93-5.mol
- MSDS File:
- SDS
| Boiling point | 475.7±51.0 °C(Predicted) |
|---|---|
| Density | 1.353±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 8.74±0.40(Predicted) |
| InChI | InChI=1S/C14H12N2OS/c1-15-10-4-2-9(3-5-10)14-16-12-7-6-11(17)8-13(12)18-14/h2-8,15,17H,1H3 |
| InChIKey | ZQAQXZBSGZUUNL-UHFFFAOYSA-N |
| SMILES | S1C2=CC(O)=CC=C2N=C1C1=CC=C(NC)C=C1 |
| CAS DataBase Reference | 566169-93-5 |
| FDA UNII | K6396E6G8G |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P301+P312-P304+P340 |
| HS Code | 2934208090 |
6-OH-BTA-1 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0092545 | Pittsburgh Compound B ≥95% | 566169-93-5 | 100mg | $180 | 2026-06-04 | Buy |
| ChemScene | CS-0092545 | Pittsburgh Compound B ≥95% | 566169-93-5 | 250mg | $275 | 2026-06-04 | Buy |
| ChemScene | CS-0092545 | Pittsburgh Compound B ≥95% | 566169-93-5 | 1g | $785 | 2026-06-04 | Buy |
| ChemScene | CS-0092545 | Pittsburgh Compound B ≥95% | 566169-93-5 | 25mg | $12128 | 2026-06-04 | Buy |
| Matrix Scientific | 202426 | 2-[4-(Methylamino)phenyl]benzo[d]thiazol-6-ol | 566169-93-5 | 25.00g | $130 | 2026-05-18 | Buy |
6-OH-BTA-1 Chemical Properties, Uses, Production
Chemical Properties
Yellow solid
Uses
Pittsburgh Compound B (PiB) is a PET tracer for Aβ deposition in Alzheimer's disease (AD), with high affinity and specificity. Through click chemistry modification (introducing a PEG3 linker and an alkyne group at the 6-hydroxy position of Pittsburgh Compound B to generate a clickable Pittsburgh Compound B derivative, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and the enrichment and characterization of Aβ complexes. Pittsburgh Compound B holds great potential in Alzheimer's disease research[1].
Synthesis
401813-34-1
566169-93-5
BBr3 (1.0 M in CH2Cl2, 10.5 mL, 10.5 mmol) was slowly added dropwise to a solution of 2-[4-(N-monomethyl)aminophenyl]-6-methoxybenzothiazole (44,588 mg, 2.06 mmol) dissolved in dichloromethane (25 mL). The reaction mixture was stirred continuously for 12 hours at room temperature. Upon completion of the reaction, water and aqueous sodium bicarbonate were carefully added to quench the reaction, followed by extraction of the organic phase with dichloromethane. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 2-[4-(N-monomethyl)aminophenyl]-6-hydroxybenzothiazole (45,530 mg, 99% yield) as a yellow solid, which did not require further purification. The structure of the product was confirmed by 1H NMR (200 MHz, DMSO-d6) and 13C NMR (100 MHz, DMSO-d6).
References
[1] Diner I, et al. Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain. Bioconjug Chem. 2017 Oct 18;28(10):2627-2637. DOI:10.1021/acs.bioconjchem.7b00500
6-OH-BTA-1 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai TuZhi Chemical Co., Ltd. | 19542790274 | 2119559397@qq.com | China | 751 | 50 |
| Liaocheng Jinge Synthetic Material CO.,LTD. | 0635-2121866 18365825121 | y18365825121@163.com | China | 110 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Tongling HengYou Biotechnology Co., Ltd. | 021-50426030 13856289449;13124863828 | 2630597085@qq.com | China | 1885 | 55 |
| Yancheng Schiemann Biological Technology Co.,Ltd | 0515-88280676; 18921872653 | sales@ximanbio.com | China | 1524 | 56 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Henan Alfachem Co.,Ltd. | 0371-55051623 18137891487 | 3983243027@qq.com | China | 9974 | 58 |
| Jiaxing Nova Chemical Co., Ltd. | 021-20921617 18957373295 | 2240425080@qq.com | China | 891 | 58 |
