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Dovitinib

Dovitinib Structure
Dovitinib structure
CAS No.
405169-16-6
Chemical Name:
Dovitinib
Synonyms
CS-226;TKI-258;CHIR-258;dovitinib;PDovitinib;NCGC00249685;CHIR258 7.7G;Dovitinib base;Unii-I35H55G906;TKI258; CHIR-258
CBNumber:
CB11512534
Molecular Formula:
C21H21FN6O
Molecular Weight:
392.43
MDL Number:
MFCD11870802
MOL File:
405169-16-6.mol
MSDS File:
SDS
Last updated:2025-05-13 19:34:56
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Dovitinib Properties

Density 1.386
storage temp. -20°
solubility Soluble in DMSO (up to 30 mg/ml).
pka 9.44±0.70(Predicted)
form solid
color Yellow-green
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference 405169-16-6
FDA UNII I35H55G906
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

Dovitinib price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15220 Dovitinib ≥98% 405169-16-6 5mg $121 2024-03-01 Buy
Cayman Chemical 15220 Dovitinib ≥98% 405169-16-6 10mg $193 2024-03-01 Buy
Cayman Chemical 15220 Dovitinib ≥98% 405169-16-6 25mg $313 2024-03-01 Buy
Cayman Chemical 15220 Dovitinib ≥98% 405169-16-6 50mg $505 2024-03-01 Buy
Biorbyt Ltd orb154678 Dovitinib (TKI258, CHIR258) >99% 405169-16-6 100mg $606.9 2021-12-16 Buy
Product number Packaging Price Buy
15220 5mg $121 Buy
15220 10mg $193 Buy
15220 25mg $313 Buy
15220 50mg $505 Buy
orb154678 100mg $606.9 Buy

Dovitinib Chemical Properties,Uses,Production

Description

Dovitinib (405169-16-6) is a potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell culture and in whole animals. Dovitinib selectively blocks the growth B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.

Uses

Compound used in treating melanoma

Uses

Dovitinib (TKI258, CHIR-258) is a multitargeted tyrosine kinase inhibitor of FLT3 and c-KIT with IC50 of 1 nM and 2 nM, respectively.

Uses

Dovitinib (TKI258, CHIR258) is a novel multi-target inhibitor for Flt3, c-Kit, FGFR1/3, VEGFR1/2/3, PDGFRα/β with IC50 of 1 nM, 2 nM, 8 nM/9 nM and 10 nM/13 nM/8 nM, 210 nM/27 nM respectively.

Uses

Dovitinib is a receptor tyrosine kinase inhibitor that targets vascular endothelial growth factor-2, basic fibroblast growth factor-1, and platelet-derived growth factor β receptors (IC50s = 65, 11, and 5 nM, respectively). At 0.04 μM, dovitinib can inhibit endothelial cell proliferation and motility. These antiangiogenic effects have been proposed to be the mechanism by which dovitinib inhibits hepatocellular carcinoma growth and metastasis. Dovitinib has been evaluated in clinical trials for the treatment of advanced solid tumors.

Definition

ChEBI: 4-amino-5-fluoro-3-[5-(4-methyl-1-piperazinyl)-1,3-dihydrobenzimidazol-2-ylidene]-2-quinolinone is a N-arylpiperazine.

in vivo

the combination of tigatuzumab and tki258 inhibited huh-7 xenograft tumor growth [3]. tki258 reduced wm tumor progression [4].

target

FLT3

IC 50

FLT3: 1 nM (IC50); c-Kit: 2 nM (IC50); FGFR1: 8 nM (IC50); FGFR3: 9 nM (IC50); VEGFR3: 8 nM (IC50); VEGFR1: 10 nM (IC50); VEGFR2: 13 nM (IC50); PDGFRβ: 27 nM (IC50); PDGFRα: 210 nM (IC50); CSF-1R: 36 nM (IC50)

References

1) Lee et al. (2005), In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models; Clin. Cancer Res., 11 3633 2) Xin et al. (2006), CHIR-258 is efficacious in a newly developed fibroblast growth factor receptor 3-expressing orthotopic multiple myeloma model in mice; Clin. Cancer Res., 12 4908

Dovitinib Preparation Products And Raw materials

Raw materials

Preparation Products

Dovitinib Suppliers

Global( 183)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29856 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		+86-86-22-87899925 +86-8618522618860 18522618860@163.com China 694 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22866 58
Supplier Advantage
Shanghai Yingrui Biopharma Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58

View Lastest Price from Dovitinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dovitinib pictures 2025-05-13 Dovitinib
405169-16-6
 US $39.00-128.00 / mg 99.78% 10g TargetMol Chemicals Inc.
Dovitinib pictures 2024-11-26 Dovitinib
405169-16-6
 US $0.00-0.00 / kg 1kg 99%, Single impurity＜0.1 1 ton Nanjing Fred Technology Co., Ltd
CHIR-258(Dovitinib,TKI258) pictures 2024-11-01 CHIR-258(Dovitinib,TKI258)
405169-16-6
 US $0.00-0.00 / bottle 1bottle 98% 100 bottles Wuhan Nutra Biotechnology Co.,Ltd
  • Dovitinib pictures
  • Dovitinib
    405169-16-6
  • US $39.00-128.00 / mg
  • 99.78%
  • TargetMol Chemicals Inc.
  • Dovitinib pictures
  • Dovitinib
    405169-16-6
  • US $0.00-0.00 / kg
  • 99%, Single impurity＜0.1
  • Nanjing Fred Technology Co., Ltd

Dovitinib Spectrum

Dovitinib(405169-16-6)1HNMR

405169-16-6(Dovitinib)Related Search:

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Momelotinib 790299-79-5 Dovitinib

1of4

4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one dovitinib 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one CS-226 CHIR-258;CHIR 258 Unii-I35H55G906 CHIR258 7.7G TKI-258 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one CHIR-258(Dovitinib,TKI258) CHIR-258(Dovitinib) TKI258; CHIR-258 Dovitinib (TKI-258) NCGC00249685 Dovitinib (TKI-258, CHIR-258) 1-aMino-5-fluoro-3-(6-(4-Methylpiperazin-1-yl)-1H-benzo[d]iMidazol-2-yl)quinolin-2(1H)-one 2(1H)-Quinolinone,4-aMino-5-fluoro-3-[5-(4-Methyl-1-piperazinyl)-1H-benziMidazol-2-yl]- (9CI) Dovitinib(CHIR-258,TKI258) 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one Dovitinib (TKI-258, CHIR-258) Dovitinib 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one CHIR-258 PDovitinib 2(1H)-Quinolinone,4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]- Dovitinib (CHIR-258) Dovitinib base CHIR-258;CHIR258;CHIR 258;TKI258;TKI-258;TKI 258 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one Dovitinib, class III-V receptor tyrosine kinase inhibitor Dovitinib, 10 mM in DMSO 405169-16-6 C21H21FN6O Inhibitors Intermediates & Fine Chemicals Pharmaceuticals API intermediates