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Teneligliptin

Teneligliptin structure

CAS No.: 760937-92-6

Chemical Name:: Teneligliptin

Synonyms: Teliglietin;teneligliptin;Teneligptin WS;Teneligliptin HB;Teneligliptin (MP-513);API (Teneligliptin free base);Teneligliptin, DPP-4 inhibitor;3-[[(2S,4R)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine;3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine;Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-

CBNumber:: CB11518541

Molecular Formula:: C22H30N6OS

Molecular Weight:: 426.58

MDL Number:: MFCD13195565

MOL File:: 760937-92-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
Teneligliptin	TRC-T018295-50MG	50mg	$182
Teneligliptin	TRC-T018295-25MG	25mg	$122
Teneligliptin	FT150538	0.5g	$900
Teneligliptin	FT150538	0.25g	$900
Teneligliptin	FT150538	0.1g	$900
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Teneligliptin Properties

Melting point	>100°C (dec.)
Boiling point	663.4±55.0 °C(Predicted)
Density	1.38
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	8.70±0.10(Predicted)
color	Off-White
InChIKey	WGRQANOPCQRCME-PMACEKPBSA-N
SMILES	C([C@@H]1C[C@H](N2CCN(C3N(C4=CC=CC=C4)N=C(C)C=3)CC2)CN1)(N1CCSC1)=O
FDA UNII	28ZHI4CF9C
ATC code	A10BH08

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Teneligliptin price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-T018295-50MG	Teneligliptin	760937-92-6	50mg	$182	2026-06-03	Buy
TRC	TRC-T018295-25MG	Teneligliptin	760937-92-6	25mg	$122	2026-06-03	Buy
Biosynth	FT150538	Teneligliptin	760937-92-6	0.5g	$900	2026-06-04	Buy
Biosynth	FT150538	Teneligliptin	760937-92-6	0.25g	$900	2026-06-04	Buy
Biosynth	FT150538	Teneligliptin	760937-92-6	0.1g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-T018295-50MG	50mg	$182	Buy
TRC-T018295-25MG	25mg	$122	Buy
FT150538	0.5g	$900	Buy
FT150538	0.25g	$900	Buy
FT150538	0.1g	$900	Buy

Teneligliptin Chemical Properties,Uses,Production

Description

Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC₅₀=0.37 nM).

Originator

Mitsubishi Tanabe Pharma (Japan)

Uses

Teneligliptin, is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.

Definition

ChEBI: Teneligliptin is an amino acid amide.

brand name

Tenelia

Pharmacokinetics

Reported evidence suggests that with teneligliptin 20 mg therapy, Tmax was 1 hour, and t1/2 was 18.9 hours. Maximum (89.7%) inhibition in plasma DPP-4 activity was noted within 2 hours and maintained >60% at 24 hours. Compared to the placebo, active plasma GLP-1 concentration was higher throughout the day and even 24 hours after administration of 20 mg of teneligliptin. Metabolism of teneligliptin was majorly mediated through CYP3A4, a cytochrome P450 isozyme, and flavin-containing monooxygenases (FMO1 and FMO3). A weak inhibitory activity of teneligliptin on CYP2D6, CYP3A4, and FMO was noted, while there was no inhibitory activity on CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C8/9, CYP2C19, and CYP2E1. There was no induction of expression of CYP1A2 or CYP3A4. Reported evidence suggests that teneligliptin is metabolized and eliminated via renal and hepatic routes. Approximately 34% of teneligliptin is excreted unchanged via the renal route, while 66% is metabolized and eliminated via the hepatic and renal routes[1].

Side effects

The DPP-4 molecule in teneligliptin reduces the risk of hypoglycemia, although it is possible. These are some of teneligliptin’s major and minor side effects:
Hypoglycemia
Headache
Upper respiratory tract infection
Gastrointestinal symptoms
Constipation
Fatigue
Kidney problems
Nasopharyngitis
Skin rashes
Itching
Loss of appetite
Abdominal pain

References

[1] Surendra Kumar Sharma. “Teneligliptin in management of type 2 diabetes mellitus.” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 9 (2016): 251–60.

Teneligliptin synthesis

Synthesis of Teneligliptin from (2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester

Teneligliptin Preparation Products And Raw materials

Raw materials

Preparation Products

Teneligliptin Suppliers

Global( 197)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChemExpress	+86-19370970350 +86-021-58950125	info@chemexpress.com	China	790	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14034	58
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
ANHUI WITOP BIOTECH CO., LTD	+8618071025641	eric@witopchemical.com	China	23504	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2240	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29096	58
AFINE CHEMICALS LIMITED	+86-571-85134551 +86-18958018566	info@afinechem.com	China	15058	58

Supplier	Advantage
ChemExpress	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
ANHUI WITOP BIOTECH CO., LTD	58
Xi'an MC Biotech, Co., Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58

Teneligliptin: Indications, Mechanism of Action and Side Effects
Teneligliptin is a novel third-generation DPP-4 inhibitor approved for the treatment of type II diabetes. The compound has a u....
Dec 16，2024

View Lastest Price from Teneligliptin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-27	Teneligliptin 760937-92-6	$30.00-40.00		99.83%	10g	TargetMol Chemicals Inc.
2025-04-04	Teneligliptin 760937-92-6		1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2024-11-26	Teneligliptin 760937-92-6		1kg	99%, Single impurity＜0.1	1 ton	Nanjing Fred Technology Co., Ltd

Teneligliptin
760937-92-6
$30.00-40.00
99.83%
TargetMol Chemicals Inc.

Teneligliptin
760937-92-6
98%
Henan Aochuang Chemical Co.,Ltd.

Teneligliptin
760937-92-6
99%, Single impurity＜0.1
Nanjing Fred Technology Co., Ltd

Teneligliptin Spectrum

Teneligliptin(760937-92-6)¹HNMR

760937-92-6(Teneligliptin)Related Search:

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Rivaroxaban Pyrrole N-Aminoethylpiperazine Basic Violet 1 Kresoxim-methyl

Polyvinylpyrrolidone Pioglitazone hydrochloride Methylparaben

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teneligliptin 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl- Teneligptin WS [(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone API (Teneligliptin free base) Teliglietin Teneligliptin (MP-513) 3-[[(2S,4R)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine ((2S,4S)-4-(4-(3-Methyl-1-phenyl1H-pyrazol-5-yl)piperazin-1yl)pyrrolidin-2-yl)(thiazolidin-3yl)methanone hydrobromide hydrate Teneligliptin, DPP-4 inhibitor Teneligliptin HB 760937-92-6 C22H30N6OS