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ChemicalBook >> CAS DataBase List >> Teneligliptin

Teneligliptin

Teneligliptin price.
  • $45 - $959.7
  • Product name: Teneligliptin
  • CAS: 760937-92-6
  • MF: C22H30N6OS
  • MW: 426.58
  • EINECS:
  • MDL Number:MFCD13195565
  • Synonyms:teneligliptin;3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine;Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-;Teneligptin WS;[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone;API (Teneligliptin free base);Teliglietin;Teneligliptin (MP-513)
Price11 Properties Safety Information Description
11 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 5MG
  • 10mg
  • 50mg
  • 100MG
  • 250mg
  • 1g
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014166
  • Product descriptionTENELIGLIPTIN 95.00%
  • Packaging5MG
  • Price$502.54
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014166
  • Product descriptionTENELIGLIPTIN 95.00%
  • Packaging100MG
  • Price$959.7
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0882
  • Product descriptionTeneligliptin 99.57%
  • Packaging10mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0882
  • Product descriptionTeneligliptin 99.57%
  • Packaging50mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0882
  • Product descriptionTeneligliptin 99.57%
  • Packaging100mg
  • Price$288
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0882
  • Product descriptionTeneligliptin 99.57%
  • Packaging250mg
  • Price$600
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000853
  • Product descriptionTeneligliptin 98+%
  • Packaging50mg
  • Price$126
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000853
  • Product descriptionTeneligliptin 98+%
  • Packaging100mg
  • Price$196
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000853
  • Product descriptionTeneligliptin 98+%
  • Packaging250mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9428
  • Product descriptionTeneligliptin >98%
  • Packaging1g
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberT018295
  • Product descriptionTeneligliptin
  • Packaging10mg
  • Price$45
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation API0014166 TENELIGLIPTIN 95.00% 5MG $502.54 2021-12-16 Buy
American Custom Chemicals Corporation API0014166 TENELIGLIPTIN 95.00% 100MG $959.7 2021-12-16 Buy
ChemScene CS-0882 Teneligliptin 99.57% 10mg $60 2021-12-16 Buy
ChemScene CS-0882 Teneligliptin 99.57% 50mg $180 2021-12-16 Buy
ChemScene CS-0882 Teneligliptin 99.57% 100mg $288 2021-12-16 Buy
ChemScene CS-0882 Teneligliptin 99.57% 250mg $600 2021-12-16 Buy
Crysdot CD31000853 Teneligliptin 98+% 50mg $126 2021-12-16 Buy
Crysdot CD31000853 Teneligliptin 98+% 100mg $196 2021-12-16 Buy
Crysdot CD31000853 Teneligliptin 98+% 250mg $420 2021-12-16 Buy
DC Chemicals DC9428 Teneligliptin >98% 1g $500 2021-12-16 Buy
TRC T018295 Teneligliptin 10mg $45 2021-12-16 Buy

Properties

Melting point :>100°C (dec.)
Boiling point :663.4±55.0 °C(Predicted)
Density :1.38
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :8.70±0.10(Predicted)
color :Off-White
InChI :InChI=1S/C22H30N6OS/c1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27/h2-6,13,19-20,23H,7-12,14-16H2,1H3/t19-,20-/m0/s1
InChIKey :WGRQANOPCQRCME-PMACEKPBSA-N
SMILES :C([C@@H]1C[C@H](N2CCN(C3N(C4=CC=CC=C4)N=C(C)C=3)CC2)CN1)(N1CCSC1)=O

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC50=0.37 nM).

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