FerroLOXIN-1
- CAS No.
- 2773428-48-9
- Chemical Name:
- FerroLOXIN-1
- Synonyms
- FerroLOXIN-1;1H-Imidazol-2-amine, 1-(3-fluorophenyl)-N-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-4-phenyl-
- CBNumber:
- CB115239386
- Molecular Formula:
- C23H16F5N3
- Molecular Weight:
- 429.39
- MDL Number:
- MOL File:
- 2773428-48-9.mol
- MSDS File:
- SDS
| Boiling point | 556.620±60.00 °C(Press: 760.00 Torr)(predicted) |
|---|---|
| Density | 1.307±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | -10 to -25°C |
| solubility | DMSO: 2mg/mL, clear (Warmed) |
| form | powder |
| pka | 7.141±0.10(predicted) |
| color | white to beige |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
FerroLOXIN-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 39325 | FerroLOXIN-1 ≥90% | 2773428-48-9 | 1mg | $32 | 2026-04-30 | Buy |
| Cayman Chemical | 39325 | FerroLOXIN-1 ≥90% | 2773428-48-9 | 5mg | $152 | 2026-04-30 | Buy |
| Cayman Chemical | 39325 | FerroLOXIN-1 ≥90% | 2773428-48-9 | 10mg | $288 | 2026-04-30 | Buy |
FerroLOXIN-1 Chemical Properties,Uses,Production
Uses
FerroLOXIN-1 is a potent inhibitor of 15LOX-2 that selectively blocked production of pro-ferroptotic HOO-ETE-PE and protected against RSL3-induced ferroptosis. FerroLOXIN-1 closely interacted therein with 15LOX-2 only, and in particular with Y154, N155, W158[1].
Biological Activity
15LOX/PEBP1 catalytic complex inhibitor th at prevents cell death by ferroptosis, but not necroptosis, pyroptosis, or apoptosis.
FerroLOXIN-1 is a ferroptosis inhibitor th at selectively targets the 15LOX/PEBP1 catalytic complex without affecting the biosynthesis of pro-/anti-inflammatory lipid mediators. FerroLOXIN-1 prevents 0.5 μM GPX4 inhibitor RSL3-induced ferroptosis in HBE cell cultures (IC50 = 84 nM post 20h RSL3 treatment) and rescues mice from total body irradiation (TBI)-induced death in vivo (Cpd administered via 25 mg/kg ip. 20h post 9.25Gy irradiation; survival on day 27 = 75% vs. 0% on day 19 of untreated control). FerroLOXIN-1 does not exert its efficacy via radical scavenging or iron-chelating activity, nor does it prevent cell death by necroptosis, pyroptosis, or apoptosis.
IC 50
5-LOX
References
[1] Dong J, et al. Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy. Angew Chem Int Ed Engl. 2023 May 22;62(22):e202303818.
FerroLOXIN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
FerroLOXIN-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 55 |
| TargetMol | 58 |
