Description
γ-Glu-Ala is an endogenous kokumi dipeptide composed of L-glutamic acid (Item No. 30377) and L-alanine (Item No. 29757) that has been found in P. roqueforti.1 It has also been found in several ripened cheeses, including Gouda, goat, and Milner cheeses. γ-Glu-Ala is a positive allosteric modulator of the calcium-sensing receptor (CaSR; EC50 = 4.8 µM in CaSR-expressing HEK293 cells).2 It induces glutathionuria in mice when administered at a dose of 4 mmol/kg.3 Plasma levels of γ-Glu-Ala are increased in malnourished neonatal mice.4 Increased serum levels of γ-Glu-Ala are positively associated with an increased risk of chronic kidney disease.5WARNING This product is not for human or veterinary use.
References
[1] SIMONE TOELSTEDE Thomas H. Kokumi-Active Glutamyl Peptides in Cheeses and Their Biogeneration by Penicillium roquefortii[J]. Journal of Agricultural and Food Chemistry, 2009, 57 9: 3738-3748. DOI: 10.1021/jf900280j
[2] GEOFFREY K BROADHEAD. Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids.[J]. The Journal of Biological Chemistry, 2011, 286 11: 8786-8797. DOI: 10.1074/jbc.m110.149724
[3] M E ANDERSON A M. Inhibition of gamma-glutamyl transpeptidase and induction of glutathionuria by gamma-glutamyl amino acids.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1986, 83 14: 5029-5032. DOI: 10.1073/pnas.83.14.5029
[4] GEOFFREY A. PREIDIS . The Undernourished Neonatal Mouse Metabolome Reveals Evidence of Liver and Biliary Dysfunction, Inflammation, and Oxidative Stress1, 2, 3[J]. Journal of Nutrition, 2014, 144 3: Pages 273-281. DOI: 10.3945/jn.113.183731
[5] HYUNJU KIM . Serum metabolomic signatures of plant-based diets and incident chronic kidney disease[J]. American Journal of Clinical Nutrition, 2022, 116 1: Pages 151-164. DOI: 10.1093/ajcn/nqac054
