Description
γ-Glu-Phe is an endogenous dipeptide that is composed of L-glutamic acid (Item No. 30377) and L-phenylalanine (Item No. 31498) and has also been found in Allium.1 It prevents increases in lipid accumulation in AML12 hepatocytes stimulated with oleic acid (Item Nos. 90260 | 24659) when used at a concentration of 30 µM. γ-Glu-Phe (2.5-10 mM) increases levels of the calcium-sensing receptor (CaSR) and secretion of cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) in STC-1 enteroendocrine cells.2 Changes in urine levels of γ-Glu-Phe are associated with hypertension and phenylketonuria (PKU) and changes in serum levels are associated with prostate cancer.3,4,5WARNING This product is not for human or veterinary use.
References
[1] YU GEON LEE. Glu-Phe from onion (Allium Cepa L.) attenuates lipogenesis in hepatocytes.[J]. Bioscience, Biotechnology, and Biochemistry, 2017, 81 7: 1409-1416. DOI: 10.1080/09168451.2017.1303358
[2] YANG J, BAI W, ZENG X, et al. γ-[Glu](n=1,2)-Phe/-Met/-Val stimulates gastrointestinal hormone (CCK and GLP-1) secretion by activating the calcium-sensing receptor[J]. Food & Function, 2019, 7: 4071-4080. DOI: 10.1039/c9fo00313d
[3] MENGYAO SHI . Metabolomics study of blood pressure salt-sensitivity and hypertension[J]. Nutrition Metabolism and Cardiovascular Diseases, 2022, 32 7: Pages 1681-1692. DOI: 10.1016/j.numecd.2022.04.002
[4] HAZEL PECK R. J P. The occurrence of γ-glutamylphenylalanine in the urine of newborn phenylketonurics[J]. Clinica Chimica Acta, 1979, 94 3: Pages 237-240. DOI: 10.1016/0009-8981(79)90070-6
[5] JIAQI HUANG. Serum metabolomic profiling of prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial[J]. British Journal of Cancer, 2016, 115 9: 1087-1095. DOI: 10.1038/bjc.2016.305
