3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid
![3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid Structure](CAS/GIF/851202-96-5.gif)
- CAS No.
- 851202-96-5
- Chemical Name:
- 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid
- Synonyms
- 3,4-Dihydro-2H-benzo[b][1,4]oxazine-7-carboxylic acid;3,4-Dihydro-2H-benzo[1,4]...;3,4-dihydro-2H-1,4-benzoxazine-7-carboxylic acid;2H-1,4-Benzoxazine-7-carboxylic acid, 3,4-dihydro-;3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid
- CBNumber:
- CB11558644
- Molecular Formula:
- C9H9NO3
- Molecular Weight:
- 179.17
- MDL Number:
- MFCD11848178
- MOL File:
- 851202-96-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 122396 | 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid | 851202-96-5 | 1.00g | $1188 | 2026-05-18 | Buy |
| Synthonix | D11868 | 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylicacid 97.0% | 851202-96-5 | 500mg | $210 | 2026-05-06 | Buy |
| Synthonix | D11868 | 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylicacid 97.0% | 851202-96-5 | 1g | $310 | 2026-05-06 | Buy |
| Synthonix | D11868 | 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylicacid 97.0% | 851202-96-5 | 5g | $1110 | 2026-05-06 | Buy |
| Synthonix | D11868 | 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylicacid 97.0% | 851202-96-5 | 10g | $2220 | 2026-05-06 | Buy |
3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid Chemical Properties, Uses, Production
Synthesis
![3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester](/CAS/GIF/142166-01-6.gif)
142166-01-6
![3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid](/CAS/GIF/851202-96-5.gif)
851202-96-5
The general procedure for the synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylic acid from methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate was as follows: methyl 3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylate (52 mmol) was dissolved in methanol (20 mL) and 2M aqueous sodium hydroxide (20 mL). The reaction was stirred at 60 °C for 48 hours. Upon completion of the reaction, the methanol was removed by rotary evaporation. The remaining aqueous phase was acidified with 4 M hydrochloric acid to pH < 3. The acidified aqueous phase was extracted three times with ethyl acetate and the organic phases were combined. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated to obtain the crude product. The crude product was purified by rapid column chromatography on silica gel with heptane/ethyl acetate gradient elution. The final product yield was 31%. The structure of the product was confirmed by 1H NMR (D6-DMSO): δ 3.33 (t, 2H); 4.10 (t, 2H); 6.51 (d, 1H); 7.16 (d, 1H); 7.30 (dd, 1H).
References
[1] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8219 - 8248
[2] Patent: WO2005/39572, 2005, A1. Location in patent: Page/Page column 33
[3] Patent: US2016/355483, 2016, A1. Location in patent: Paragraph 0382-0383
3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4554 | 55 |
| Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd. | 19943855286 | 94644163@qq.com | China | 1934 | 56 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3970 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25333 | 58 |
