3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester
![3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Structure](CAS/GIF/142166-01-6.gif)
- CAS No.
- 142166-01-6
- Chemical Name:
- 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester
- Synonyms
- methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate;Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylate;3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester;methyl methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate;3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl es...;2H-1,4-Benzoxazine-7-carboxylic acid, 3,4-dihydro-, methyl ester;3,4-Dihydro-7-(methoxycarbonyl)-2H-1,4-benzoxazine, 3,4-Dihydro-7-(methoxycarbonyl)-2H-benzo[b][1,4]oxazine
- CBNumber:
- CB41558645
- Molecular Formula:
- C10H11NO3
- Molecular Weight:
- 193.2
- MDL Number:
- MFCD11848180
- MOL File:
- 142166-01-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate ≥95% | OR16468 | 250mg | $33 |
| Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate | 047430 | 1.00g | $67 |
| Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate | 047430 | 5.00g | $201 |
| Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate | 047430 | 10.00g | $365 |
| Methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate 97+% | M52596 | 100mg | $45 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2934999090 |
3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR16468 | Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate ≥95% | 142166-01-6 | 250mg | $33 | 2026-06-04 | Buy |
| Matrix Scientific | 047430 | Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate | 142166-01-6 | 1.00g | $67 | 2026-05-18 | Buy |
| Matrix Scientific | 047430 | Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate | 142166-01-6 | 5.00g | $201 | 2026-05-18 | Buy |
| Matrix Scientific | 047430 | Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate | 142166-01-6 | 10.00g | $365 | 2026-05-18 | Buy |
| Synthonix | M52596 | Methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate 97+% | 142166-01-6 | 100mg | $45 | 2026-05-06 | Buy |
3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Chemical Properties,Uses,Production
Uses
Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylate is used as a research compound and in organic synthesis, etc.
Synthesis
142166-00-5
![3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester](/CAS/GIF/142166-01-6.gif)
142166-01-6
Methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate (1 g, 4.83 mmol) was used as starting material and mixed with boron trifluoride ethyl ether complex (1.273 mL, 10.14 mmol) in tetrahydrofuran (20 mL). The reaction mixture was stirred at 0 °C for 20 min. Subsequently, sodium borohydride (0.383 g, 10.14 mmol) was slowly added to the reaction system and stirring was continued at 0 °C for 1 h. The reaction was then brought to room temperature overnight. Upon completion of the reaction, ethyl acetate (~1 mL) was added to dilute the reaction, which was subsequently quenched by the addition of 1N aqueous hydrochloric acid. Extraction was carried out with ethyl acetate at room temperature, and the organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and finally concentrated under reduced pressure to afford the target product, methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate (0.916 g, 4.74 mmol, 98% yield), as a light yellow solid.
References
[1] Patent: WO2018/30550, 2018, A1. Location in patent: Paragraph 0658
[2] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8219 - 8248
3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49923 | 58 |
| Wuhan Konberd Biotech Co., Ltd | +undefined18986093962 | admin@konberdbio.com | China | 1378 | 58 |
| Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9999 | 58 |
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