ChemicalBook >> CAS DataBase List >>3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester structure

CAS No.: 142166-01-6

Chemical Name:: 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester

Synonyms: methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate;Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylate;3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester;methyl methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate;3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl es...;2H-1,4-Benzoxazine-7-carboxylic acid, 3,4-dihydro-, methyl ester;3,4-Dihydro-7-(methoxycarbonyl)-2H-1,4-benzoxazine, 3,4-Dihydro-7-(methoxycarbonyl)-2H-benzo[b][1,4]oxazine

CBNumber:: CB41558645

Molecular Formula:: C10H11NO3

Molecular Weight:: 193.2

MDL Number:: MFCD11848180

MOL File:: 142166-01-6.mol

MSDS File:: SDS

Last updated:2026-08-25 20:17:46

Request For Quotation

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Properties

Melting point	86~88℃
Boiling point	337.2±41.0 °C(Predicted)
Density	1.198±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	2.00±0.20(Predicted)
Appearance	Off-white to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2934999090

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR16468	Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate ≥95%	142166-01-6	250mg	$33	2026-06-04	Buy
Matrix Scientific	047430	Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate	142166-01-6	1.00g	$67	2026-05-18	Buy
Matrix Scientific	047430	Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate	142166-01-6	5.00g	$201	2026-05-18	Buy
Matrix Scientific	047430	Methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate	142166-01-6	10.00g	$365	2026-05-18	Buy
Synthonix	M52596	Methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate 97+%	142166-01-6	100mg	$45	2026-05-06	Buy

Product number	Packaging	Price	Buy
OR16468	250mg	$33	Buy
047430	1.00g	$67	Buy
047430	5.00g	$201	Buy
047430	10.00g	$365	Buy
M52596	100mg	$45	Buy

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Chemical Properties,Uses,Production

Uses

Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylate is used as a research compound and in organic synthesis, etc.

Synthesis

methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate

142166-00-5

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester

142166-01-6

Methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate (1 g, 4.83 mmol) was used as starting material and mixed with boron trifluoride ethyl ether complex (1.273 mL, 10.14 mmol) in tetrahydrofuran (20 mL). The reaction mixture was stirred at 0 °C for 20 min. Subsequently, sodium borohydride (0.383 g, 10.14 mmol) was slowly added to the reaction system and stirring was continued at 0 °C for 1 h. The reaction was then brought to room temperature overnight. Upon completion of the reaction, ethyl acetate (~1 mL) was added to dilute the reaction, which was subsequently quenched by the addition of 1N aqueous hydrochloric acid. Extraction was carried out with ethyl acetate at room temperature, and the organic layer was separated, washed with saturated brine, dried over anhydrous sodium sulfate, and finally concentrated under reduced pressure to afford the target product, methyl 3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate (0.916 g, 4.74 mmol, 98% yield), as a light yellow solid.

References

[1] Patent: WO2018/30550, 2018, A1. Location in patent: Paragraph 0658
[2] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8219 - 8248

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

1,2-Dibromoethane methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate Methyl 4-amino-3-hydroxybenzoate Sodium borohydride Boron trifluoride diethyl etherate

Tetrahydrofuran

1of2

Preparation Products

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Suppliers

Global( 90)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7882	64
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
skychemical Co.Ltd	021-20958197 20965099	sales@skychemical.com	China	1182	57
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Changzhou Wanyao Biotechnology Co., Ltd.	0519-89185693 15312551983	2410037592@qq.com	China	278	55
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9336	55
Shanghai Keepontech Co.,Ltd	021-54849683 13601642561	sales@keepontech.com	China	997	59

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
Shangchem Co., Ltd.	52
Tetranov Biopharm	64
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
skychemical Co.Ltd	57
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Changzhou Wanyao Biotechnology Co., Ltd.	55
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
Shanghai Keepontech Co.,Ltd	59

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester Spectrum

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester(142166-01-6)¹HNMR

142166-01-6(3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester)Related Search:

methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-7-carboxylate 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid 3,4-Dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid methyl ester methyl 4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate Methyl 5-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate

3,4-dihydro-2h-1,4-benzoxazine-7-carboxylic acid hydrochloride

1of2

3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate Methyl 3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylate 3,4-Dihydro-7-(methoxycarbonyl)-2H-1,4-benzoxazine, 3,4-Dihydro-7-(methoxycarbonyl)-2H-benzo[b][1,4]oxazine methyl methyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxylate 2H-1,4-Benzoxazine-7-carboxylic acid, 3,4-dihydro-, methyl ester 3,4-Dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl es... 142166-01-6