RIBOSTAMYCIN SULFATE SALT
- CAS No.
- 25546-65-0
- Chemical Name:
- RIBOSTAMYCIN SULFATE SALT
- Synonyms
- ribostamycin;sf733;ribomycin;NSC 138925;vistamycin;dekamyciniv;hetangmycin;antibioticsf733;RIBOSTAMYCIN SULPHATE;RIBOSTAMYCIN DISULFATE
- CBNumber:
- CB1165751
- Molecular Formula:
- C17H34N4O10
- Molecular Weight:
- 454.47
- MDL Number:
- MFCD00057496
- MOL File:
- 25546-65-0.mol
- MSDS File:
- SDS
| Melting point | 192-195°; mp 175-180° (dec) |
|---|---|
| alpha | D23 +42° |
| Boiling point | 561.28°C (rough estimate) |
| Density | 1.1751 (rough estimate) |
| refractive index | 1.6700 (estimate) |
| storage temp. | 2-8°C |
| pka | 7.70(at 25℃) |
| FDA UNII | 2Q5JOU7T53 |
| ATC code | J01GB10 |
SAFETY
Risk and Safety Statements
| Hazard Codes | T |
|---|---|
| Risk Statements | 61-20/21/22 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | WK2300000 |
| Toxicity | mouse,LD50,intracrebral,66800ug/kg (66.8mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDLUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2489, 1970. |
RIBOSTAMYCIN SULFATE SALT price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 257381 | Ribostamycin sulphate | 25546-65-0 | 100mg | $446 | 2026-06-03 | Buy |
| Usbiological | 257381 | Ribostamycin sulphate | 25546-65-0 | 250mg | $631 | 2026-06-03 | Buy |
| Usbiological | 257381 | Ribostamycin sulphate | 25546-65-0 | 500mg | $814 | 2026-06-03 | Buy |
| Usbiological | 257381 | Ribostamycin sulphate | 25546-65-0 | 1g | $1204 | 2026-06-03 | Buy |
| Usbiological | 257381 | Ribostamycin sulphate | 25546-65-0 | 2g | $1451 | 2026-06-03 | Buy |
RIBOSTAMYCIN SULFATE SALT Chemical Properties, Uses, Production
Description
Ribostamycin was found in the culture broth of Streptomyces ribosidificus by Meiji Seika Kaisha in 1970 in the course of screening aminoglycoside antibiotics. It is structurally related to neomycin but lacks the diaminoidose (glucose) moiety substituted on the ribose moiety. Ribostamycin is much less toxic than neomycin and shows strong activity against a variety of gram-positive and gram-negative bacteria, except Pseudomonas aeruginosa. It is used parenterally for therapy of urinary tract, respiratory tract, surgical, and other infections.
Uses
Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of PDI[1][2].
Definition
ChEBI: An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attache at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus).
Mechanism of action
Ribostamycin (SF-733) is produced by Streptomyces ribosidificus. The free base is crystallized from methanol solution. The structure has been determined by chemical methods and total synthesis has been undertaken .
in vivo
Ribostamycin (40 mg/kg, intramuscular injection, per day for 14 days) causes little nephrotoxicity in rats(evaluated by urinalysis)[5].
IC 50
Aminoglycoside
References
[1] Zheng T, et al. Linear self-assembly formation between gold nanoparticles and aminoglycoside antibiotics. Colloids Surf B Biointerfaces. 2018 Apr 1;164:185-191. DOI:10.1016/j.colsurfb.2018.01.027
[2] Hunfeld KP, et al. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001 Mar;17(3):203-8. DOI:10.1016/s0924-8579(00)00342-3
[3] Horibe T, et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001 Dec 21;289(5):967-72. DOI:10.1006/bbrc.2001.6105
[4] Kong J, et al. Exploration of Antibiotic Activity of Aminoglycosides, in Particular Ribostamycin Alone and in Combination With Ethylenediaminetetraacetic Acid Against Pathogenic Bacteria. Front Microbiol. 2020 Jul 29;11:1718. DOI:10.3389/fmicb.2020.01718
[5] Kitasato I, et al. Comparative nephrotoxicity of ribostamycin and gentamicin in rats evaluated by urinalysis. Drugs Exp Clin Res. 1989;15(6-7):273-89. PMID:2591299
RIBOSTAMYCIN SULFATE SALT Preparation Products And Raw materials
Raw materials
Preparation Products
RIBOSTAMYCIN SULFATE SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
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| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9983 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Hubei Xinyang Medical Technology Co., Ltd | 15347293736 | 2853117764@yongstandards.com | China | 9999 | 58 |
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| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +86-13670046396 | export03@qcsrm.com | China | 24318 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TLC Pharmaceutical Standards Ltd. | 18012923235 | chinasales04@tlcstandards.com.cn | China | 8143 | 58 |
