2-chloro-N-(2,2,2-trifluoroethyl)acetamide
- CAS No.
- 170655-44-4
- Chemical Name:
- 2-chloro-N-(2,2,2-trifluoroethyl)acetamide
- Synonyms
- 2-chloro-N-(2,2,2-trifluoroethyl)acetamide;2-CgHLORO-N-(2,2,2-TRIFLUOROETHYL)ACETAMIDE;AcetaMide, 2-chloro-N-(2,2,2-trifluoroethyl)-
- CBNumber:
- CB11690689
- Molecular Formula:
- C4H5ClF3NO
- Molecular Weight:
- 175.54
- MDL Number:
- MFCD03984449
- MOL File:
- 170655-44-4.mol
- MSDS File:
- SDS
| Boiling point | 218 ºC |
|---|---|
| Density | 1.368 |
| Flash point | 86 ºC |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 11.89±0.46(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C4H5ClF3NO/c5-1-3(10)9-2-4(6,7)8/h1-2H2,(H,9,10) |
| InChIKey | IRIXZMVHMMALGW-UHFFFAOYSA-N |
| SMILES | C(NCC(F)(F)F)(=O)CCl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501 |
| HS Code | 2924297099 |
2-chloro-N-(2,2,2-trifluoroethyl)acetamide price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC201170 | 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide 98% | 170655-44-4 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC201170 | 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide 98% | 170655-44-4 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC201170 | 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide 98% | 170655-44-4 | 1g | $64 | 2026-06-04 | Buy |
| Apolloscientific | PC201170 | 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide 98% | 170655-44-4 | 5g | $187 | 2026-06-04 | Buy |
| Apolloscientific | PC201170 | 2-Chloro-N-(2,2,2-trifluoroethyl)acetamide 98% | 170655-44-4 | 25g | $490 | 2026-06-04 | Buy |
2-chloro-N-(2,2,2-trifluoroethyl)acetamide Chemical Properties, Uses, Production
Synthesis
373-88-6
79-04-9
170655-44-4
GENERAL STEPS: 30.4 g (759.3 mmol) of sodium hydroxide and 50 mL of water were added to a 500 mL four-necked flask and stirred at room temperature until completely dissolved, then cooled to 5 °C. A solution was prepared by dissolving 50 g (370.4 mmol) of 2,2,2-trifluoroethylamine hydrochloride in 60 mL of water and added slowly and dropwise to the above sodium hydroxide solution at 5 °C. 85 mL of tert-butyl methyl ether was added and stirred continuously for 30 minutes. Subsequently, a solution of 43.9 g (388.9 mmol) of chloroacetyl chloride dissolved in 15 mL of tert-butyl methyl ether was added slowly dropwise while maintaining 5°C. The reaction mixture was heated to 10 °C and stirring was continued for 1 hour. After confirming complete consumption of 2,2,2-trifluoroethylamine by gas chromatography, the reaction mixture was warmed up to room temperature and partitioned. The aqueous layer was extracted with 100 mL of tert-butyl methyl ether, all organic layers were combined, and the solvent was concentrated by distillation under reduced pressure to give a tert-butyl methyl ether solution of 2-chloro-N-(2,2,2-trifluoroethyl)acetamide. The product was analyzed by high performance liquid chromatography with internal standard method to give 65 g of product in 100% yield and a solution concentration of 25.1% by weight. The solution was added dropwise to heptane to induce crystallization, and the melting point of the resulting 2-chloro-N-(2,2,2-trifluoroethyl)acetamide was 53.8 °C (as determined by DSC).
References
[1] Patent: JP5652628, 2015, B2. Location in patent: Paragraph 0057
[2] Inorganic Chemistry, 2018, vol. 57, # 17, p. 11252 - 11263
[3] Chemical Communications, 2016, vol. 52, # 96, p. 13885 - 13888
2-chloro-N-(2,2,2-trifluoroethyl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-chloro-N-(2,2,2-trifluoroethyl)acetamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD | 571-89189769 15168342188 | China | 228 | 62 | |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2277 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
View Latest Price from 2-chloro-N-(2,2,2-trifluoroethyl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | 2-chloro-N-(2,2,2-trifluoroethyl)acetamide
170655-44-4
|
$1.00 | 1g | 98% | 200kgs | Career Henan Chemical Co | |
|
|
2020-01-10 | 2-chloro-N-(2,2,2-trifluoroethyl)acetamide
170655-44-4
|
$1.00 | 1g | 98% | 200kgs | Career Henan Chemical Co |
-
- 2-chloro-N-(2,2,2-trifluoroethyl)acetamide
170655-44-4
- $1.00
- 98%
- Career Henan Chemical Co
-
- 2-chloro-N-(2,2,2-trifluoroethyl)acetamide
170655-44-4
- $1.00
- 98%
- Career Henan Chemical Co
