2,2,2-Trifluoroethylamine hydrochloride
- CAS No.
- 373-88-6
- Chemical Name:
- 2,2,2-Trifluoroethylamine hydrochloride
- Synonyms
- TAF;2,2,2-Trifluoroethanamine hydrochloride;TRIFLUOROETHYLAMINE HYDROCHLORIDE;2,2,2-Trifluoroethyla;2-AMINO-1,1,1-TRIFLUOROETHANE HYDROCHLORIDE;2,2,2-TRIFLUORO-;2,2,2-TrifluoroethylamineHCl;2,2,2-Trifluoro-ethanamine HCl;trifluoro-ethylaminhydrochloride;2,2,2-Trifluoroaminehydrochloride
- CBNumber:
- CB4396448
- Molecular Formula:
- C2H5ClF3N
- Molecular Weight:
- 135.52
- MDL Number:
- MFCD00012875
- MOL File:
- 373-88-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 220-222 °C (subl.)(lit.) |
|---|---|
| Density | 1,24g/cm |
| refractive index | 1,3-1,302 |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| Water Solubility | It is Soluble in 0.7 to water, but soluble in ethanol and chloroform, slightly soluble in benzene, hardly soluble in ether. |
| Sensitive | Hygroscopic |
| BRN | 3652103 |
| InChI | InChI=1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H |
| InChIKey | ZTUJDPKOHPKRMO-UHFFFAOYSA-N |
| SMILES | C(F)(F)(F)CN.Cl |
| CAS DataBase Reference | 373-88-6(CAS DataBase Reference) |
| EPA Substance Registry System | Ethanamine, 2,2,2-trifluoro-, hydrochloride (373-88-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,T,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 36/37-24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KS0250000 | |||||||||
| F | 3-10-21 | |||||||||
| Hazard Note | Hygroscopic/Toxic | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29211990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral |
|||||||||
| Toxicity | LD50 unr-mus: 476 mg/kg 11FYAN 3,81,63 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,2,2-Trifluoroethylamine hydrochloride price More Price(74)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 180386 | 2,2,2-Trifluoroethylamine hydrochloride 98% | 373-88-6 | 10g | $132 | 2026-04-30 | Buy |
| Sigma-Aldrich | 180386 | 2,2,2-Trifluoroethylamine hydrochloride 98% | 373-88-6 | 50g | $304 | 2026-04-30 | Buy |
| TCI Chemical | T1170 | 2,2,2-Trifluoroethylamine Hydrochloride >98.0%(N)(T) | 373-88-6 | 5g | $23 | 2026-04-30 | Buy |
| TCI Chemical | T1170 | 2,2,2-Trifluoroethylamine Hydrochloride >98.0%(N)(T) | 373-88-6 | 25g | $58 | 2026-04-30 | Buy |
| Usbiological | 289845 | 2,2,2-Trifluoroethylamine HCl Asreported | 373-88-6 | 10g | $315 | 2026-06-03 | Buy |
2,2,2-Trifluoroethylamine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
WHITE TO LIGHT YELLOW CRYSTALLINE POWDER
Uses
2,2,2-Trifluoroethylamine Hydrochloride is a reagent in the synthesis of arachidonylethanolamide analogs. These show affinity for CB1 and CB2 cannabinoid receptors.
Safety Profile
Moderately toxic by unspecifiedroute. When heated to decomposition it emits very toxicfumes of F, NOx, and HCl.
Synthesis
753-90-2
373-88-6
General procedure for the synthesis of 2,2,2-trifluoroethylamine hydrochloride from 2,2,2-trifluoroethylamine: 100 g of ethanol and 33 g of 2,2,2-trifluoroethylamine were added to a triple-necked flask, and 35 g of saturated hydrochloric acid solution was added slowly and dropwise at temperatures lower than 25°C. The reaction system was then brought up to 50°C and maintained there for 1 hour. After the dropwise addition, the temperature of the reaction system was raised to 50 °C and maintained for 1 hour. Subsequently, the temperature of the reaction solution was controlled to be 45±5°C under a vacuum of 0.98 MPa and a decompression distillation was carried out for 5 hours to remove water and ethanol. Finally 43.5 g of 2,2,2-trifluoroethylamine hydrochloride was obtained in 96.30% yield. The resulting product was a white powdery crystalline solid with 0.13% water.
References
[1] Patent: CN105801428, 2016, A. Location in patent: Paragraph 0016; 0017
2,2,2-Trifluoroethylamine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD | 571-89189769 15168342188 | China | 228 | 62 | |
| JIANGYIN RUISHIPHARM CO.,LIMITED | 0510-0510-66227179 18921203887 | sales@ruishipharm.com | China | 747 | 58 |
| shanghaidelaikekejiyouxiangongsi | 17351445187 | 3528434302@qq.com | China | 282 | 58 |
| Hangzhou Cedareal Technology Co., Ltd. | 13858087543 | 368073698@qq.com | China | 46 | 58 |
| Jinkai (Liaoning) Life Technology Co., LTD | 021-64272437 | customer-service@kingchem.com | China | 201 | 58 |
| Shandong Dexin Fine Chemical Co., Ltd. | 18553366272 | 3091507995@qq.com | China | 278 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Lastest Price from 2,2,2-Trifluoroethylamine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2,2,2-trifluoroethanaminium chloride
373-88-6
|
$2.00-5.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-08-20 | 2,2,2-Trifluoroethylamine hydrochloride
373-88-6
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | 2,2,2-Trifluoroethylamine hydrochloride
373-88-6
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- 2,2,2-trifluoroethanaminium chloride
373-88-6
- $2.00-5.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2,2,2-Trifluoroethylamine hydrochloride
373-88-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,2,2-Trifluoroethylamine hydrochloride
373-88-6
- 98%
- Shaanxi Dideu New Materials Co. Ltd
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