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Boc-His(Dnp)-OH

Boc-His(Dnp)-OH structure

CAS No.: 25024-53-7

Chemical Name:: Boc-His(Dnp)-OH

Synonyms: N-Me-L-Phe;BOC-HIS(DNP);Boc-His(Dnp)-OH;BOC-L-HIS(DNP)-OH;BOC-L-HISTIDINE (DNP);TBOC-L-HISTIDINE (DNP);BOC-HIS(DNP)-OH IPA 98%;BOC-HIS(DNP)-OH USP/EP/BP;BOC-L-DINITROPHENYL HISTIDINE;na-T-boc-N-im-dnp-L-histidine

CBNumber:: CB1176418

Molecular Formula:: C17H19N5O8

Molecular Weight:: 421.36

MDL Number:: MFCD00065966

MOL File:: 25024-53-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:49:00

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Boc-His(Dnp)-OH Properties

Melting point	98-100 °C (dec.)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Solid
optical activity	[α]20/D +61±3°, c = 1% in ethyl acetate
Water Solubility	Slightly soluble in water.
Sensitive	Light Sensitive
BRN	771922
Major Application	peptide synthesis
InChI	1S/C17H19N5O8/c1-17(2,3)30-16(25)19-12(15(23)24)6-10-8-20(9-18-10)13-5-4-11(21(26)27)7-14(13)22(28)29/h4-5,7-9,12H,6H2,1-3H3,(H,19,25)(H,23,24)/t12-/m0/s1
InChIKey	KPGVUOQMOHGHEW-LBPRGKRZSA-N
SMILES	CC(C)(C)OC(=O)N[C@@H](Cc1cn(cn1)-c2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)C(O)=O
CAS DataBase Reference	25024-53-7(CAS DataBase Reference)
EPA Substance Registry System	L-Histidine, N-[(1,1-dimethylethoxy)carbonyl]-1-(2,4-dinitrophenyl)- (25024-53-7)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Hazard statements

H314

Precautionary statements

P264b-P271-P280-P301+P330+P331-P304+P340-P305+P351+P338-P310-P363-P403+P233-P501c

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

TSCA

TSCA listed

Storage Class

11 - Combustible Solids

NFPA 704

	0
0		0

Boc-His(Dnp)-OH price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	15287	Boc-His(Dnp)-OH ≥98.0% (TLC)	25024-53-7	5g	$177	2023-06-20	Buy
ChemPep	110906-25G	Boc-His(Dnp)-OH	25024-53-7	25g	$188	2026-06-04	Buy
ChemScene	CS-W009689	(S)-2-((tert-Butoxycarbonyl)amino)-3-(1-(2,4-dinitrophenyl)-1H-imidazol-4-yl)propanoic acid ≥97%	25024-53-7	25g	$111	2026-06-04	Buy
ChemPep	110906-100G	Boc-His(Dnp)-OH	25024-53-7	100g	$518	2026-06-04	Buy
Chem-Impex	01357	Nα-Boc-Nim-2,4-dinitrophenyl-L-histidine·isopropanol ≥99%(HPLC)	25024-53-7	5G	$25	2026-05-19	Buy

Product number	Packaging	Price	Buy
15287	5g	$177	Buy
110906-25G	25g	$188	Buy
CS-W009689	25g	$111	Buy
110906-100G	100g	$518	Buy
01357	5G	$25	Buy

Boc-His(Dnp)-OH Chemical Properties, Uses, Production

Synthesis

Starting with 2,4-dinitrophenyl-L-histidine, the target compound BOC-HIS(DNP)-OH was prepared by an amino-protection reaction with di-tert-butyl dicarbonate.

Synthesis of 25024-53-7

Figure 1

Synthesis of BOC-HIS(DNP)-OH

Experimental Procedure:

2,4-Dinitrophenyl-L-histidine was dissolved in 100 mL of sodium hydroxide aqueous solution. 200 mL of tetrahydrofuran and 250 g of di-tert-butyl dicarbonate were added sequentially. The pH was controlled at 8-9. After reacting for 12 h, the mixture was extracted twice with 500 mL of ethyl acetate each time. The aqueous phase was then acidified with HCl to pH 1-2, and the product was extracted three times with 500 mL of ethyl acetate each time. The ester layers were combined and washed twice with 200 mL of saturated brine each time. The mixture was dried over anhydrous sodium sulfate for 12 h, filtered, concentrated, crystallized, and dried at 40-50 °C to obtain BOC-HIS(DNP)-OH.

Chemical Properties

Yellow solid

Uses

The Dnp group is stable to HF and TFMSA.

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Boc-His(Dnp)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

Boc-His(Dnp)-OH Suppliers

Global Suppliers ( 189)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
China DongFan Chemical Co.,LTD	66

View Latest Price from Boc-His(Dnp)-OH manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-12	BOC-HIS(DNP)-OH 25024-53-7	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
	2019-07-06	BOC-HIS(DNP)-OH 25024-53-7	$1.00	1UG	98%	100KG	Career Henan Chemical Co

BOC-HIS(DNP)-OH
25024-53-7
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

BOC-HIS(DNP)-OH
25024-53-7
$1.00
98%
Career Henan Chemical Co

25024-53-7 (Boc-His(Dnp)-OH) Related Search:

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Boc-His(Dnp)-OH 4-(1H-Imidazol-1-yl)aniline Carbamic acid, [2-(1H-imidazol-4-yl)ethyl]-, 1,1-dimethylethyl ester (9CI) Boc-Lys(Dnp)-OH Boc-Orn(Dnp)-OH

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1of4

BOC-L-DINITROPHENYL HISTIDINE BOC-L-HIS(DNP)-OH BOC-L-HISTIDINE (DNP) N_α-Boc-N(im)-2,4-dinitrophenyl-L-histidine na-T-boc-N-im-dnp-L-histidine N-(tert-butoxycarbonyl)-1-(2,4-dinitrophenyl)-L-histidine N-α-Boc-N-im-dinitrophenyl-L-histidine BOC-HIS(DNP) (2S)-2-(tert-butoxycarbonylamino)-3-[1-(2,4-dinitrophenyl)imidazol-4-yl]propionic acid nα-boc-n(im)-2,4-dinitrophenyl-l-histidine NA-BOC-N(IM)-2,4-DINITROPHENYL-L-HISTIDINE N2-BOC-N-IM-DINITROPHENYL-L-HISTIDINE Nalpha-(tert-butoxycarbonyl)-N-dinitrophenyl-L-histidine Nα-[(1,1-Dimethylethoxy)carbonyl]-1-(2,4-dinitrophenyl)-L-histidine 3-[1-(2,4-dinitrophenyl)-4-imidazolyl]-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid (2S)-3-[1-(2,4-dinitrophenyl)imidazol-4-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Boc-N-iM-2,4-dinitrophenyl-L-histidine N-Boc-1-(2,4-dinitrophenyl)-L-histidine, 99% Nα-Boc-Nim-2,4-dinitrophenyl-L-histidine·isopropanol≥ 99% (HPLC) N-ALPHA-BOC-NIM-DINITROPHENYL-L-HISTIDINE N-ALPHA-BOC-NIM-2,4-DINITROPHENYL-L-HISTIDINE N-ALPHA-T-BOC-N-IM-2,4-DINITROPHENYL-L-HISTIDINE N-ALPHA-T-BOC-N-IM-DINITROPHENYL-L-HISTIDINE TBOC-L-HISTIDINE (DNP) n-[(1,1-dimethylethoxy)carbonyl]-1-(2,4-dinitrophenyl)-l-histidin Boc-His(Dnp)-OH >=98.0% (TLC) (2S)-3-[1-(2,4-dinitrophenyl)imidazol-4-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoicaci BOC-HIS(DNP)-OH USP/EP/BP (S)-2-((tert-Butoxycarbonyl)amino)-3-(1-(2,4-dinitrophenyl)-1H-imidazol-4-yl)propanoic acid BOC-HIS(DNP)-OH IPA 98% N-Me-L-Phe Boc-His(Dnp)-OH 25024-53-7 C20H27N5O9 C17H19N5O8 Amino Acid Derivatives Specialty Synthesis Peptide Synthesis Histidine Histidine [His, H] Boc-Amino Acids and Derivative Boc-Amino acid series Amino Acid Derivatives Amino Acids