PAROXETINE-D4 HCL
- CAS No.
- 110429-35-1
- Chemical Name:
- PAROXETINE-D4 HCL
- Synonyms
- PAROXETINE HYDROCHLORIDE HEMIHYDRATE;PAROXETINE HCL HEMIHYDRATE;paroxetine hydrochloride hydrate;Paroxetine-D4 hydrochloride;Piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, hydrochloride, hydrate (2:1), (3S-trans)-;PAROXETINE-D4 HCL;BRL29060A hemihydrate;PAROXETINE-D4 HCL USP/EP/BP;PAROXETINE HYDROCHLORIDE 1/2H2O;Paroxetine hydrochloride 98~102%
- CBNumber:
- CB1178023
- Molecular Formula:
- C19H23ClFNO4
- Molecular Weight:
- 383.84
- MDL Number:
- MFCD00797405
- MOL File:
- 110429-35-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 121-131 C |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Slightly soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent) and in methylene chloride. |
| form | powder |
| color | white |
| λmax | 292nm(H2O)(lit.) |
| Merck | 14,7043 |
| InChI | InChI=1/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/s3 |
| InChIKey | QRQSGFFISBKLMZ-BGBHMREKNA-N |
| SMILES | C([C@@H]1CNCC[C@H]1C1C=CC(F)=CC=1)OC1C=CC2OCOC=2C=1.Cl.O |&1:1,6,r| |
| CAS DataBase Reference | 110429-35-1 |
| FDA UNII | X2ELS050D8 |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H317-H319-H411 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | F,C,Xn | |||||||||
| Risk Statements | 11-34-36/37/38-22 | |||||||||
| Safety Statements | 16-26-36/37/39-45-36 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TM4569320 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Skin Sens. 1 STOT SE 3 |
|||||||||
| NFPA 704 |
|
PAROXETINE-D4 HCL price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000630 | Paroxetine for system suitability European Pharmacopoeia (EP) Reference Standard | 110429-35-1 | 20 μg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0000281 | Paroxetine hydrochloride hemihydrate European Pharmacopoeia (EP) Reference Standard | 110429-35-1 | 200 mg | $164 | 2026-04-30 | Buy |
| Sigma-Aldrich | P9623 | Paroxetine hydrochloride hemihydrate ≥98% (HPLC), powder | 110429-35-1 | 10mg | $194 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP746 | Paroxetine impurity standard British Pharmacopoeia (BP) Reference Standard | 110429-35-1 | 25MG | $251 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP1024 | Paroxetine hydrochloride hemihydrate British Pharmacopoeia (BP) Reference Standard | 110429-35-1 | 200MG | $267 | 2026-04-30 | Buy |
PAROXETINE-D4 HCL Chemical Properties, Uses, Production
Chemical Properties
White or almost white, crystalline powder.
Uses
Paroxetine Hydrochloride, is a selective serotonin reuptake inhibitor (SSRI) antidepressant used to treat depression, panic attacks, obsessive-compulsive disorder (OCD), anxiety disorders, post-traumatic stress disorder, and a severe form of premenstrual syndrome (premenstrual dysphoric disorder).
Uses
Antidepressant;5-HT uptake inhibitor
Uses
Paroxetine hydrochloride hemihydrate has been used: as an antidepressant to study its effects on neural stem cells (NSCs) from embryonic rat hippocampus in vitro; as a CYP 2D6 inhibitor to study its effects on the in vitroproduction by human recombinant CYP 2D6 of the phenolic metabolites; as an antidepressant to study its effects on the expression of pituitary adenylate cyclase activating polypeptide (PACAP), its receptors and brain-derived neurotrophic factor (BDNF) in rat primary hippocampal neurons
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Biochem/physiol Actions
Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant
in vivo
Paroxetine treatment obviously attenuates the symptoms of CIA rats. Paroxetine treatment clearly prevents the histological damage of joints and alleviates T cells infiltration into synovial tissue. Paroxetine reveals a strong effect on inhibiting CX3CL1 production in synovial tissues[1]. Paroxetine (20 mg/kg/day) reduces the myocyte cross-sectional area in rat and ROS formation in the remote myocardium. Paroxetine reduces the susceptibility to ventricular tachycardia. Paroxetine treatment following MI decreases LV remodeling and susceptibility to arrhythmias, probably by reducing ROS formation[2]. In CCI paroxetine-treated group, paroxetine (10 mg/kg, i.p.) produces hyperalgesia at days 7 and 10 (P<0.01), but a decrease in pain behavior is seen at day 14. Moreover, paroxetine (10 mg/kg) significantly attenuates tactile hypersensitivity when compared to CCI vehicle-treated group[5].
PAROXETINE-D4 HCL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Benoy Chemical Co., Ltd. | 17342059697 | sales@benoychem.com | China | 209 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9791 | 79 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
View Latest Price from PAROXETINE-D4 HCL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | PAROXETINE-D4 HCL USP/EP/BP
110429-35-1
|
$1.10 | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-07-15 | Paroxetine hydrochloride hemihydrate
110429-35-1
|
$30.00-57.00 | 99.94% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-04-12 | Paroxetine hydrochloride;Paroxetine hcl
110429-35-1
|
$1.00 | 1Kg/Bag | 99.83% HPLC | 5000tons/year | Wuhan Dujiang Industrial Co., Ltd. |
-
- PAROXETINE-D4 HCL USP/EP/BP
110429-35-1
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Paroxetine hydrochloride hemihydrate
110429-35-1
- $30.00-57.00
- 99.94%
- TargetMol Chemicals Inc.
-
- Paroxetine hydrochloride;Paroxetine hcl
110429-35-1
- $1.00
- 99.83% HPLC
- Wuhan Dujiang Industrial Co., Ltd.
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