1-Methylindole-3-carboxaldehyde
- CAS No.
- 19012-03-4
- Chemical Name:
- 1-Methylindole-3-carboxaldehyde
- Synonyms
- 1-METHYL-1H-INDOLE-3-CARBALDEHYDE;3-formyl-1-methylindole;NSC 83042;AKOS JY2082515;RARECHEM AH BS 0121;TIMTEC-BB SBB010057;N-Methyl-3-formylindole;ASINEX-REAG BAS 12967420;N-methyl-3-carboxaldehyde;1 METHYLINDOLE-3-ALDEHYDE
- CBNumber:
- CB1201057
- Molecular Formula:
- C10H9NO
- Molecular Weight:
- 159.18
- MDL Number:
- MFCD00014570
- MOL File:
- 19012-03-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 70-72 °C (lit.) |
|---|---|
| Boiling point | 186-189 °C(Press: 3-4 Torr) |
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Crystalline Powder and Chunks |
| color | Light yellow to orange or brown |
| Water Solubility | Insoluble in water. |
| Sensitive | Air Sensitive |
| BRN | 121302 |
| InChI | 1S/C10H9NO/c1-11-6-8(7-12)9-4-2-3-5-10(9)11/h2-7H,1H3 |
| InChIKey | KXYBYRKRRGSZCX-UHFFFAOYSA-N |
| SMILES | Cn1cc(C=O)c2ccccc12 |
| CAS DataBase Reference | 19012-03-4(CAS DataBase Reference) |
| FDA UNII | Z612E3VMZ5 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
1-Methylindole-3-carboxaldehyde price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 357987 | 1-Methylindole-3-carboxaldehyde 97% | 19012-03-4 | 5g | $79.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 357987 | 1-Methylindole-3-carboxaldehyde 97% | 19012-03-4 | 25g | $515 | 2023-06-20 | Buy |
| TCI Chemical | M1520 | 1-Methyl-1H-indole-3-carbaldehyde min. 98.0 % | 19012-03-4 | 5G | $42 | 2026-04-30 | Buy |
| TCI Chemical | M1520 | 1-Methyl-1H-indole-3-carbaldehyde min. 98.0 % | 19012-03-4 | 25G | $150 | 2026-04-30 | Buy |
| Apolloscientific | OR22346 | 1-Methyl-1H-indole-3-carboxaldehyde 98% | 19012-03-4 | 5g | $21 | 2026-06-04 | Buy |
1-Methylindole-3-carboxaldehyde Chemical Properties, Uses, Production
Chemical Properties
light yellow to orange or brown crystalline powder
Uses
Reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions Reactant for synthesis of quinolinones via three-component Ugi reaction Reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture Reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins Reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent Reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents.
Uses
1-Methylindole-3-carboxaldehyde is used as a reactant for preparation of nitroolefins and β-nitroalcohols via microwave- or ultrasound-assisted Henry reactions, reactant for synthesis of quinolinones via three-component Ugi reaction, reactant for synthesis of α-ketoamides as inhibitors of Dengue virus protease with antiviral activity in cell-culture, reactant for preparation of thiazolopyrimidinones as inhibitors of Bcl-2 proteins, reactant for preparation of vinylindoles via Peterson olefination or olefination with Nysted reagent, reactant for preparation of indolyl alkenes from microwave-enhanced Knoevenagel condensation as antibacterial agents 1-Methylindole-3-carboxaldehyde may be used in the synthesis of (Z)-3-(1-methyl-1H-indol-3-yl)-2-(thiophen-3-yl)acrylonitrile, via base-catalyzed condensation with thiophene-3-acetonitrile. It was also used in the preparation of monomer, required for the synthesis of poly(3-vinyl-1-methylindole).
Synthesis Reference(s)
Tetrahedron, 49, p. 4015, 1993 DOI: 10.1016/S0040-4020(01)89915-4
Synthesis, p. 396, 1987 DOI: 10.1055/s-1987-27960
General Description
1-Methylindole-3-carboxaldehyde is a heterocyclic indole aldehyde. 1-Methylindole-3-carboxaldehyde on condensation with 2-hydroxybenzohydrazide yields Schiff base.
1-Methylindole-3-carboxaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 1-Methylindole-3-carboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-25 | 1-Methylindole-3-carboxaldehyde
19012-03-4
|
$1.00 | 1KG | 99 | 100T | Henan Xiangtong Chemical Co., Ltd. | |
 |
2021-08-12 | 1-Methylindole-3-carboxaldehyde
19012-03-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 1-Methylindole-3-carboxaldehyde
19012-03-4
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 1-Methylindole-3-carboxaldehyde
19012-03-4
- $1.00
- 99
- Henan Xiangtong Chemical Co., Ltd.
-
- 1-Methylindole-3-carboxaldehyde
19012-03-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-Methylindole-3-carboxaldehyde
19012-03-4
- $8.80
- 97%-99%
- Career Henan Chemical Co
