ESTETROL
- CAS No.
- 15183-37-6
- Chemical Name:
- ESTETROL
- Synonyms
- E 4;(8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol;UBE4A;UBOX3;UFD2A;HDNB1;Donesta;ESTETROL;KIAA0126;KIAA0684
- CBNumber:
- CB1210710
- Molecular Formula:
- C18H24O4
- Molecular Weight:
- 304.38
- MDL Number:
- MFCD00198996
- MOL File:
- 15183-37-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Estetrol ≥98% (HPLC) | SML1523 | 5mg | $241 |
| Estetrol ≥98% (HPLC) | SML1523 | 25mg | $958 |
| Estetrol ≥95% | 18232 | 500μg | $35 |
| Estetrol ≥95% | 18232 | 1mg | $63 |
| UBE4A Purifiedbyimmunoaffinitychromatography. | 529455 | 100ul | $736 |
| More product size | |||
| Melting point | 233-236°C |
|---|---|
| Boiling point | 491.9±45.0 °C(Predicted) |
| Density | 1.343±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 10.22±0.70(Predicted) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +125 to +135, c = 1 in ethanol |
| InChI | InChI=1/C18H24O4/c1-18-7-6-12-11-5-3-10(19)8-9(11)2-4-13(12)14(18)15(20)16(21)17(18)22/h3,5,8,12-17,19-22H,2,4,6-7H2,1H3/t12-,13-,14-,15-,16-,17+,18+/s3 |
| InChIKey | AJIPIJNNOJSSQC-VRHMYLLRNA-N |
| SMILES | [C@@]12([H])CCC3C=C(O)C=CC=3[C@@]1([H])CC[C@]1(C)[C@H]([C@H](O)[C@H](O)[C@@]21[H])O |&1:0,11,15,17,18,20,22,r| |
| FDA UNII | ENB39R14VF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H362-H351-H360 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P201-P260-P263-P264-P270-P308+P313 |
| REACH Registrations | Active |
ESTETROL price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1523 | Estetrol ≥98% (HPLC) | 15183-37-6 | 5mg | $241 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1523 | Estetrol ≥98% (HPLC) | 15183-37-6 | 25mg | $958 | 2026-04-30 | Buy |
| Cayman Chemical | 18232 | Estetrol ≥95% | 15183-37-6 | 500μg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 18232 | Estetrol ≥95% | 15183-37-6 | 1mg | $63 | 2021-12-16 | Buy |
| Usbiological | 529455 | UBE4A Purifiedbyimmunoaffinitychromatography. | 100ul | $736 | 2026-06-03 | Buy |
ESTETROL Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol and estriol during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium). In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.
Uses
A metabolite of Estradiol. It is an estrogenic steroid synthesized exclusively by the fetal liver during human pregnancy and reaching the maternal circulation through the placenta.
Definition
ChEBI: Estetrol is a 3-hydroxy steroid that is 17beta-estradiol which has been substituted at the 15alpha and 16alpha positions by two additional hydroxy groups. It is a natural estrogen produced exclusively during pregnancy by the fetal liver. It has a role as an estrogen, an estrogen receptor agonist, a human metabolite, a human xenobiotic metabolite and an oral contraceptive. It is a 3-hydroxy steroid, a 17beta-hydroxy steroid, a 16alpha-hydroxy steroid, a 15alpha-hydroxy steroid and a steroid hormone. It derives from a hydride of an estrane.
in vivo
Estetrol (0.6 and 6 mg/kg/day, mixed in diet, 12 weeks) induces an atheroprotective effect in mice, with an ERα‐dependent manner[3].
Estetrol (0.03-3.0 mg/kg, p.o., twice daily for four consecutive days) inhibits ovulation in rats[5].
| Animal Model: | Four‐week‐old ovariectomized ERα+/+LDL‐r/ or ERα/LDL‐r/ mice were switched to atherogenic diet from the age of 6-18 weeks[1] |
| Dosage: | 0.6 or 6 mg/kg/day |
| Administration: | mixed in atherogenic diet, 12 weeks |
| Result: | Decreased total plasma cholesterol at 6 mg/kg/day in ERα+/+LDLr/ but not in ERα/LDLr/ mice. Prevented lipid deposition in ovariectomized ERα+/+LDLr/ mice. |
ESTETROL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 3999 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +86-18627785180 | info@finetechnology-ind.com | China | 9539 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9932 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| Hubei KDG Web Science&Technology Co., Ltd | sales@kdg-tech.com | China | 931 | 58 | |
| Chongqing jooe co., ltd | +86-15223382610 | info@jooe.com | China | 15950 | 58 |
| EZM SCIENCES LIMITED | +undefined18218469372 | ezmscience@pm.me | China | 499 | 58 |
