2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione
![2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione Structure](CAS/GIF/91833-49-7.gif)
- CAS No.
- 91833-49-7
- Chemical Name:
- 2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione
- Synonyms
- 2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione;2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f][1,4]oxazepine-5(2H)-thione;Pyrido[3,2-f]-1,4-oxazepine-5(2H)-thione, 2-[2-(dimethylamino)ethyl]-3,4-dihydro-4-methyl-
- CBNumber:
- CB12199778
- Molecular Formula:
- C13H19N3OS
- Molecular Weight:
- 265.37
- MDL Number:
- MOL File:
- 91833-49-7.mol
- MSDS File:
- SDS
| Melting point | 130-133 °C |
|---|---|
| Boiling point | 379.0±52.0 °C(Predicted) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 9.18±0.28(Predicted) |
| FDA UNII | 3391H2J6G4 |
2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | RDA83349 | Rocastine | 91833-49-7 | 1mg | $1427.8 | 2026-06-05 | Buy |
| ChemScene | CS-6727 | Rocastine | 91833-49-7 | 1mg | $1459 | 2026-06-04 | Buy |
| ChemScene | CS-6727 | Rocastine | 91833-49-7 | 5mg | $2940 | 2026-06-04 | Buy |
| aablocks | AA01EOIJ | Rocastine | 91833-49-7 | 1mg | $849 | 2026-05-30 | Buy |
| aablocks | AA01EOIJ | Rocastine | 91833-49-7 | 5mg | $1694 | 2026-05-30 | Buy |
2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione Chemical Properties, Uses, Production
Uses
Rocastine is a selective, nonsedating H1 antagonist, acting as an antihistamine.
in vivo
Rocastine is effective with a 15 min pretreatment time (PD50 = 0.13 mg/kg) as it is with a 1 hr pretreatment time (PD50 = 0.12 mg/kg). Rocastine protects guinea pigs from collapse induced by aerosolized antigen; rocastine is approximately 36x more potent than diphenhydramine and as potent as oxatomide and terfenadine. Rocastine does not alter the EEG of cats at doses in vast excess (150x) of its antihistaminic dose nor does it potentiate yohimbine toxicity in mice[1].
References
[1] Nolan JC, et al. Rocastine (AHR-11325), a rapid acting, nonsedating antihistamine. Agents Actions. 1989 Aug;28(1-2):53-61. DOI:10.1007/BF02022980
2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione Preparation Products And Raw materials
Raw materials
Preparation Products
2-[2-(Dimethylamino)ethyl]-3,4-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepine-5(2H)-thione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| SHAANXI?DIDEU?MEDICHEM CO.LTD | 17691182729 17392216275 | 1073@dideu.com | China | 9993 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +86-19133911216 | Nancy@kangcang.com.cn | China | 335 | 58 |
