2-(4-Aminophenyl)quinoline
- CAS No.
- 22191-97-5
- Chemical Name:
- 2-(4-Aminophenyl)quinoline
- Synonyms
- 4-(2-quinolyl)aniline;4-quinolin-2-ylaniline;2-(4-Aminophenyl)quinoline;4-(2-Quinolinyl)benzenamine;[4-(2-quinolyl)phenyl]amine;(4-Quinolin-2-ylphenyl)amine;Benzenamine, 4-(2-quinolinyl)-;BF-170 hydrochloride >=98% (HPLC), solid
- CBNumber:
- CB12285246
- Molecular Formula:
- C15H12N2
- Molecular Weight:
- 220.27
- MDL Number:
- MFCD08705340
- MOL File:
- 22191-97-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20°C |
|---|---|
| solubility | H2O: soluble10mg/mL |
| form | solid |
| color | orange |
| Water Solubility | H2O: 10mg/mL |
| InChI | 1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H |
| InChIKey | UYYPMQOFLJHJAW-UHFFFAOYSA-N |
| SMILES | Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H318-H335 |
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 |
| target organs | Respiratory system |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
2-(4-Aminophenyl)quinoline price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B4311 | BF-170 hydrochloride ≥98% (HPLC), solid | 22191-97-5 | 5mg | $129 | 2026-04-30 | Buy |
| Sigma-Aldrich | B4311 | BF-170 hydrochloride ≥98% (HPLC), solid | 22191-97-5 | 25mg | $441 | 2026-04-30 | Buy |
| aablocks | AA00BKWM | 4-(quinolin-2-yl)aniline ≥98%(HPLC) | 22191-97-5 | 5mg | $254 | 2026-05-28 | Buy |
| aablocks | AA00BKWM | 4-(quinolin-2-yl)aniline ≥98%(HPLC) | 22191-97-5 | 10mg | $390 | 2026-05-28 | Buy |
| aablocks | AA00BKWM | 4-(quinolin-2-yl)aniline ≥98%(HPLC) | 22191-97-5 | 25mg | $792 | 2026-05-28 | Buy |
2-(4-Aminophenyl)quinoline Chemical Properties, Uses, Production
Uses
BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes). BF-170 can be used as a probe for tau protein pathology imaging in Alzheimer's disease (AD). It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases[1].
Biological Activity
BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimerμs disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.
References
[1] Okamura N, et al. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. J Neurosci. 2005 Nov 23;25(47):10857-62. DOI:10.1523/JNEUROSCI.1738-05.2005
2-(4-Aminophenyl)quinoline Preparation Products And Raw materials
Raw materials
Preparation Products
2-(4-Aminophenyl)quinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2968 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
| Suzhou Rovathin Foreign Trade Co.,Ltd | 0512-65816829 18662214788 | info@rovathin.com.cn | China | 9959 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12577 | 58 |
| Wuxi Lihengsheng Biopharmaceutical Technology Co., Ltd | 15250805028 15250805028 | 649163353@qq.com | China | 8000 | 58 |
