5-Nitrophthalazine
- CAS No.
- 89898-86-2
- Chemical Name:
- 5-Nitrophthalazine
- Synonyms
- 5-Nitrophthalazine;Phthalazine, 5-nitro-
- CBNumber:
- CB1230756
- Molecular Formula:
- C8H5N3O2
- Molecular Weight:
- 175.14
- MDL Number:
- MFCD08236796
- MOL File:
- 89898-86-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2933998090 |
5-Nitrophthalazine price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR903009 | 5-Nitrophthalazine 95% | 89898-86-2 | 100mg | $98 | 2026-06-04 | Buy |
| Apolloscientific | OR903009 | 5-Nitrophthalazine 95% | 89898-86-2 | 250mg | $165 | 2026-06-04 | Buy |
| Apolloscientific | OR903009 | 5-Nitrophthalazine 95% | 89898-86-2 | 1g | $444 | 2026-06-04 | Buy |
| Apolloscientific | OR903009 | 5-Nitrophthalazine 95% | 89898-86-2 | 5g | $1552 | 2026-06-04 | Buy |
| Activate Scientific | AS30341 | 5-Nitrophthalazine 95% | 89898-86-2 | 1g | $172 | 2026-06-04 | Buy |
5-Nitrophthalazine Chemical Properties, Uses, Production
Uses
5-nitrophthalazine is a useful chemical in the formation of a photothermographic material and used for image forming.
Synthesis
253-52-1
89898-86-2
The general procedure for the synthesis of 5-nitrophthalazine from 2,3-diazanaphthalene was as follows: 3.0 g (23.3 mmol) of 2,3-diazanaphthalene was dissolved in 20 mL of concentrated sulfuric acid and heated up to 100°C. The reaction was carried out in the following manner. Within 1 hour, 18.8 g (186 mmol) of potassium nitrate was added to the reaction system in batches. The reaction temperature was maintained at 100 °C for 72 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature, slowly poured into ice water and neutralized to neutrality with ammonium hydroxide solution, at which time a yellow-brown precipitate was generated. The precipitate was collected by filtration and dried to give 2.3 g (56% yield) of 5-nitrophthalazine intermediate as a light yellow solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (100.17 MHz, DMSO-d6) as follows: 1H NMR δ: 10.2 (s, 1H), 9.98 (s, 1H), 8.84 (d, J = 7.4 Hz, 1H), 8.59 (d, J = 7.6 Hz. 1H), 8.20 (dd, J = 7.4,14.9 Hz, 1H); 13C NMR δ: 152.1,146.3,141.0,133.2,131.8,130.0,127.4,118.7.
References
[1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 9, p. 3938 - 3942
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 478 - 487
[3] Journal of Medicinal Chemistry, 1986, vol. 29, # 8, p. 1329 - 1340
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 744 - 752
[5] Patent: US2006/116368, 2006, A1. Location in patent: Page/Page column 35
5-Nitrophthalazine Preparation Products And Raw materials
5-Nitrophthalazine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
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| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20788 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
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| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
