α-MSH (11-13) (free acid)
- CAS No.
- 67727-97-3
- Chemical Name:
- α-MSH (11-13) (free acid)
- Synonyms
- KPV;Lys-pro-val;Lys-Pro-Val-OH;H-Lys-Pro-Val-OH;α-Melanotropin(11-13);KPV (Lysine-Proline-Valine);HCG，G2K;HCG，G5K;HCG，G10K;KPV -678
- CBNumber:
- CB1241534
- Molecular Formula:
- C16H30N4O4
- Molecular Weight:
- 342.43
- MDL Number:
- MFCD00804591
- MOL File:
- 67727-97-3.mol
- MSDS File:
- SDS
| storage temp. | -15°C |
|---|---|
| InChI | InChI=1S/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1 |
| InChIKey | YSPZCHGIWAQVKQ-AVGNSLFASA-N |
| SMILES | C(O)(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N |
α-MSH (11-13) (free acid) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM109220 | Alpha-MSH (11-13) (free acid) acetate salt | 67727-97-3 | 0.1g | $343.75 | 2026-06-04 | Buy |
| Biosynth | FM109220 | Alpha-MSH (11-13) (free acid) acetate salt | 67727-97-3 | 0.25g | $550 | 2026-06-04 | Buy |
| Biosynth | FM109220 | Alpha-MSH (11-13) (free acid) acetate salt | 67727-97-3 | 0.5g | $825 | 2026-06-04 | Buy |
| Biosynth | FM109220 | Alpha-MSH (11-13) (free acid) acetate salt | 67727-97-3 | 1g | $1031.25 | 2026-06-04 | Buy |
| Biosynth | FM109220 | Alpha-MSH (11-13) (free acid) acetate salt | 67727-97-3 | 2g | $1375 | 2026-06-04 | Buy |
α-MSH (11-13) (free acid) Chemical Properties,Uses,Production
Description
α-MSH (11-13) (free acid) is a synthetic, nonsteroidal compound that binds to and activates α-melanocyte-stimulating hormone receptors. It has been used as an antiinflammatory agent in the treatment of inflammatory bowel disease and bowel disease. It is also being studied as a contraceptive and an elastase inhibitor. This drug has shown some promise in the treatment of autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, multiple sclerosis, and type 1 diabetes mellitus. It is thought that α-MSH (11-13) (free acid) acetate salt may inhibit the production of inflammatory cells by inhibiting leukocyte elastase activity.
Uses
α-MSH(11-13) (ACTH-(11-13)) is the 11-13 amino acid (lysine-proline-valine) sequence of α-MSH (HY-P0252), which reduces fever in rabbits[1].
Definition
ChEBI: Lys-Pro-Val is an oligopeptide.
Biological Activity
The C-terminal tripeptide α-MSH(11–13), also known as KPV (L-Lys-L-Pro-L-Val), exhibited anti-inflammation without induction of cutaneous pigmentation in a frog skin bioassay. The underlying molecular mechanisms of the α-MSH(11–13) anti-inflammatory properties have not been determined in detail. However, they are related to an inhibition of TNF-α, IL-6, and nitric oxide production in a model of LPS-stimulated murine microglial cell culture[1]. Furthermore, it has been recently shown that α-MSH(11–13) reduces activation of NF-κB and decreases its translocation into the nucleus by interaction with importin family proteins.
References
[1] Eva-Verena Schaible. “Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice.” PLoS ONE (2013): e71056.
α-MSH (11-13) (free acid) Preparation Products And Raw materials
Raw materials
Preparation Products
α-MSH (11-13) (free acid) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Emeishan Hongsen Biopharmaceutical Co., Ltd. | 0833-6186278 19162541913 | sales@hongshengpharm.com | China | 99 | 60 |
| Chengdu Maidisen Biotechnology Co., Ltd. | 19981944287 | info@cdmds.com | China | 111 | 58 |
| Haikou Xingyuan Biotechnology Co., Ltd | 19138726419 | 3823925625@qq.com | China | 78 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
| Zhejiang Jiekun Biotechnology Co., Ltd | 0571-88211921 15397062932 | sales1@gotopbio.com | China | 4864 | 58 |
| Nanjing Typeptide Biotechnology Co.,Ltd. | 19961912513; 19941518170 | sales@typeptide.com | China | 4433 | 58 |
| Nanjing Nor Biotechnology Co., Ltd | 17768782665 17768782665 | 1711908659@qq.com | China | 202 | 58 |
| CHENGDU TLKTECH CO.,LTD | 15228898511 | yxhuang@yontinotech.com | China | 241 | 58 |
| Yangzhou Jiebai Biotechnology Co., Ltd | 18068553911 | ruiyunting@jiebaibio.com | China | 13 | 58 |
| Changsha Morning Shine Co., Ltd. | 189-75832125 13397510867 | BD@csmspharm.com | China | 553 | 58 |
View Lastest Price from α-MSH (11-13) (free acid) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-12 | Klow (BPC15710+TB10+GhkCU50+KPV10)
67727-97-3
|
$1.00 | 1box | 99% | 100000 | Tianjin Shunzhicheng Technology Co., Ltd. | |
 |
2026-09-12 | Glow (GHK-CU-50mg，BPC-157，TB-50010mg)
67727-97-3
|
$1.00 | 1box | 99% | 100000 | Tianjin Shunzhicheng Technology Co., Ltd. | |
 |
2026-09-12 | KPV
67727-97-3
|
$1.00 | 1box | 99% | 100000 | Tianjin Shunzhicheng Technology Co., Ltd. |
-
- Klow (BPC15710+TB10+GhkCU50+KPV10)
67727-97-3
- $1.00
- 99%
- Tianjin Shunzhicheng Technology Co., Ltd.
-
- Glow (GHK-CU-50mg，BPC-157，TB-50010mg)
67727-97-3
- $1.00
- 99%
- Tianjin Shunzhicheng Technology Co., Ltd.
-
- KPV
67727-97-3
- $1.00
- 99%
- Tianjin Shunzhicheng Technology Co., Ltd.
