3,5-Dichloro-4-fluorobenzotrifluoride
- CAS No.
- 77227-81-7
- Chemical Name:
- 3,5-Dichloro-4-fluorobenzotrifluoride
- Synonyms
- 1,3-DICHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)BENZENE;3,5-Dichloro-4-fluoronitrobezene;3,5-DICHLORO-4-FLUOROBENZOTRIFLUORIDE;3,5-dichloro-4- chlorobenzotrifluoride;3,5-Dichloro-4-fluorobenzotrifluoride98%;3,5-Dichloro-4-fluorobenzotrifluoride 98%;2,6-Dichloro-4-trifluoromethylfluorobenzene;Benzene, 1,3-dichloro-2-fluoro-5-(trifluoromethyl)-;3,5-DICHLORO-ALPHA,ALPHA,ALPHA-4-TETRAFLUOROTOLUENE;3,5-dichloro-4-fluoro-alpha,alpha,alpha-trifluorotoluene
- CBNumber:
- CB1242849
- Molecular Formula:
- C7H2Cl2F4
- Molecular Weight:
- 232.99
- MDL Number:
- MFCD00068183
- MOL File:
- 77227-81-7.mol
- MSDS File:
- SDS
| Boiling point | 166-168 °C (lit.) |
|---|---|
| Density | 1.555 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 164 °F |
| storage temp. | Storage temp. 2-8°C |
| form | liquid |
| color | Clear |
| BRN | 6199573 |
| InChI | 1S/C7H2Cl2F4/c8-4-1-3(7(11,12)13)2-5(9)6(4)10/h1-2H |
| InChIKey | BWQFQKZDLBJZAW-UHFFFAOYSA-N |
| SMILES | Fc1c(Cl)cc(cc1Cl)C(F)(F)F |
| CAS DataBase Reference | 77227-81-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H318 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P305+P351+P338+P310 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 2810 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29039990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 |
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| NFPA 704 |
|
3,5-Dichloro-4-fluorobenzotrifluoride price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 416576 | 3,5-Dichloro-4-fluorobenzotrifluoride 98% | 77227-81-7 | 5g | $203 | 2023-01-07 | Buy |
| Apolloscientific | PC2403 | 3,5-Dichloro-4-fluorobenzotrifluoride 98% | 77227-81-7 | 1g | $62 | 2026-06-04 | Buy |
| Apolloscientific | PC2403 | 3,5-Dichloro-4-fluorobenzotrifluoride 98% | 77227-81-7 | 5g | $104 | 2026-06-04 | Buy |
| Apolloscientific | PC2403 | 3,5-Dichloro-4-fluorobenzotrifluoride 98% | 77227-81-7 | 25g | $313 | 2026-06-04 | Buy |
| SynQuest Laboratories | 1800-7-54 | 3,5-Dichloro-4-fluorobenzotrifluoride 98% | 77227-81-7 | 25g | $250 | 2026-05-22 | Buy |
3,5-Dichloro-4-fluorobenzotrifluoride Chemical Properties,Uses,Production
Chemical Properties
CLEAR LIGHT YELLOW LIQUID
Uses
3,5-Dichloro-4-fluorobenzotrifluoride may be used for the synthesis of 3-[4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]]-3-(trifluoromethyl)diazirine.
General Description
3,5-Dichloro-4-fluorobenzotrifluoride is an aryl fluorinated building block.
Synthesis
In a 1L three-necked reaction flask equipped with a stirrer, reflux condenser and temperature ground, 200 g of 3,4,5-trichlorobenzotrifluoride and 200 g of potassium fluoride and 500 ml of cyclobutanesulfone were added, then heated to 190C, kept warm and stirred for 20 hours and then cooled down to 100C. 200 g of the crude product (containing about 10% of the cyclobutanesulfone) was evaporated under 0.01 MPa pressure. Then the temperature was raised to 150 and the pressure was reduced to recover the cyclobutanesulfone (can be directly used in the next batch of reaction). 200 g of crude 3,5-dichloro-4-fluorobenzotrifluoride was directly used in the next step of the ammoniation reaction.
3,5-Dichloro-4-fluorobenzotrifluoride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
View Lastest Price from 3,5-Dichloro-4-fluorobenzotrifluoride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-03-20 | 3,5-Dichloro-4-fluorobenzotrifluoride
77227-81-7
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2026-02-02 | 3,5-Dichloro-4-fluorobenzotrifluoride
77227-81-7
|
50mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2021-08-12 | 3,5-Dichloro-4-fluorobenzotrifluoride
77227-81-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3,5-Dichloro-4-fluorobenzotrifluoride
77227-81-7
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3,5-Dichloro-4-fluorobenzotrifluoride
77227-81-7
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 3,5-Dichloro-4-fluorobenzotrifluoride
77227-81-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
