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4-Chloro-2-(trifluoromethyl)phenol

4-Chloro-2-(trifluoromethyl)phenol Structure
4-Chloro-2-(trifluoromethyl)phenol structure
CAS No.
53903-51-8
Chemical Name:
4-Chloro-2-(trifluoromethyl)phenol
Synonyms
UKRORGSYN-BB BBV-5105736;4-Chloro-2-(trifluoromethyl)phenol;Phenol, 4-chloro-2-(trifluoromethyl)-
CBNumber:
CB12448384
Molecular Formula:
C7H4ClF3O
Molecular Weight:
196.55
MDL Number:
MFCD00060673
MOL File:
53903-51-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:49:05
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4-Chloro-2-(trifluoromethyl)phenol Properties

Boiling point 189.0±35.0 °C(Predicted)
Density 1.474±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 7.54±0.43(Predicted)
Appearance Off-white to light brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Corrosion (GHS05)
GHS07,GHS05
Signal word  Danger
Hazard statements  H315-H318-H335-H302
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310-P264-P270-P301+P312-P330-P501
HS Code  2908990000

4-Chloro-2-(trifluoromethyl)phenol price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC500173 4-Chloro-2-(trifluoromethyl)phenol 98% 53903-51-8 250mg $21 2026-06-04 Buy
Apolloscientific PC500173 4-Chloro-2-(trifluoromethyl)phenol 98% 53903-51-8 1g $36 2026-06-04 Buy
Apolloscientific PC500173 4-Chloro-2-(trifluoromethyl)phenol 98% 53903-51-8 5g $164 2026-06-04 Buy
Apolloscientific PC500173 4-Chloro-2-(trifluoromethyl)phenol 98% 53903-51-8 25g $796 2026-06-04 Buy
Apolloscientific PC500173 4-Chloro-2-(trifluoromethyl)phenol 98% 53903-51-8 100g $2692 2026-06-04 Buy
Product number Packaging Price Buy
PC500173 250mg $21 Buy
PC500173 1g $36 Buy
PC500173 5g $164 Buy
PC500173 25g $796 Buy
PC500173 100g $2692 Buy

4-Chloro-2-(trifluoromethyl)phenol Chemical Properties, Uses, Production

Synthesis

2-Amino-5-chlorobenzotrifluoride

445-03-4

4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL

53903-51-8

The general procedure for the synthesis of 2-trifluoromethyl-4-chlorophenol from 2-amino-5-chlorobenzotrifluoride was as follows: an aqueous solution (2 mL) of NaNO2 (0.458 g, 6.63 mmol) was slowly added to a cooled mixture of 4-chloro-2-trifluoromethylaniline (1.08 g, 5.52 mmol) dissolved in 33% H2SO4 (40 mL) at 0 °C in a cooled mixture of 33% H2SO4 (40 mL). After 3 hours of reaction, urea (0.100 g, 1.67 mmol) was added and stirring was continued for 10 minutes. Subsequently, the reaction mixture was poured into 100 mL of preheated 33% H2SO4 and heated to reflux for 1 hour and then cooled to room temperature. The reaction mixture was extracted with EtOAc, the organic phase was washed sequentially with water and saturated NaCl solution, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Purification by silica gel column chromatography with 20% EtOAc/hexane as eluent gave 4-chloro-2-trifluoromethylphenol (0.245 g, 23% yield). The product was detected by mass spectrometry (ion spray) showing m/z = 195 (M-1) and 1H NMR (CDCl3) data as follows: δ 7.49 (d, 1H), 7.38 (dd, 1H), 6.91 (d, 1H), 5.44 (brs, 1H).

References

[1] Patent: WO2005/92835, 2005, A1. Location in patent: Page/Page column 37

4-Chloro-2-(trifluoromethyl)phenol Preparation Products And Raw materials

Raw materials

2-Amino-5-chlorobenzotrifluoride 4-Amino-2-(trifluoromethyl)phenol Urea Sulfuric acid Sodium nitrite

Preparation Products

4-Chloro-2-(trifluoromethyl)phenol Suppliers

Global Suppliers ( 69)
Supplier Tel Email Country ProdList Advantage
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Wuhan ariel chemical Co., LTD. 18986259541 18986259541 sales@3stc.com China 3828 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Tianjin Anhao Biological Technology Co., Ltd. sales@ahpharmatech.com China 5734 55
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
LABTER PHARMATECH(BEIJING) CO.,LTD 010-56330744 18310155299 sales@labter.com.cn China 19999 55
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Changzhou Anxuan Chemical, Co., Ltd. 13912302692 sales@anxuanchem.com China 4824 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
PharmaBlock Sciences (Nanjing),Inc. 55
Shandong Xiya Chemical Co., Ltd 57
Wuhan ariel chemical Co., LTD. 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Tianjin Anhao Biological Technology Co., Ltd. 55
Shanghai HuanChuan Industry Co.,Ltd. 50
LABTER PHARMATECH(BEIJING) CO.,LTD 55
Cool Pharm, Ltd 58
Changzhou Anxuan Chemical, Co., Ltd. 58
Amadis Chemical Company Limited 58

View Latest Price from 4-Chloro-2-(trifluoromethyl)phenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL pictures 2020-01-09 4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL
53903-51-8
 $1.00 1KG 95%-99% 1ton Career Henan Chemical Co

4-Chloro-2-(trifluoromethyl)phenol Spectrum

4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL(53903-51-8)1HNMR4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL(53903-51-8)19FNMR

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UKRORGSYN-BB BBV-5105736 Phenol, 4-chloro-2-(trifluoromethyl)- 4-Chloro-2-(trifluoromethyl)phenol 53903-51-8