FRESELESTAT
- CAS No.
- 208848-19-5
- Chemical Name:
- FRESELESTAT
- Synonyms
- ONO6818;ONO 6818;ONO-6818;Freselesat;ONO-PO-736;FRESELESTAT;Freselestat (ONO-6818);5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide;1(6H)-PyriMidineacetaMide,5-aMino-N-[1-[[5-(1,1-diMethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-Methylpropyl]-6-oxo-2-phenyl-
- CBNumber:
- CB12451308
- Molecular Formula:
- C23H28N6O4
- Molecular Weight:
- 452.51
- MDL Number:
- MFCD09837826
- MOL File:
- 208848-19-5.mol
| Melting point | 151-153oC |
|---|---|
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 12.43±0.46(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| FDA UNII | 1CW4RL23VP |
FRESELESTAT price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5651 | ONO6818 ≥98%(HPLC) | 208848-19-5 | 10 | $252 | 2021-12-16 | Buy |
| TRC | F764500 | Freselestat | 208848-19-5 | 2.5mg | $120 | 2021-12-16 | Buy |
| TRC | F764500 | Freselestat | 208848-19-5 | 25mg | $990 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008113 | ONO-6818 95.00% | 208848-19-5 | 1G | $918.23 | 2021-12-16 | Buy |
| ChemScene | CS-0007925 | Freselestat | 208848-19-5 | 10mg | $600 | 2021-12-16 | Buy |
FRESELESTAT Chemical Properties,Uses,Production
Uses
Freselestat is a highly potent nonpeptidic orally active inhibitor of human neutrophil elastase (HNE) and can be used as treatment for neutrophil-predominant inflammatory lung diseases.
in vivo
Freselestat (ONO-6818; 10-100 mg/kg; oral administration; daily; for 8 weeks) treatment attenuates dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid. ONO-6818 inhibits acute lung injury induced by HNE by minimizing lung hemorrhage and accumulation of neutrophils in the lung[1].
| Animal Model: | Male Wistar rats (228 g) induced by human neutrophil elastase (HNE)[1] |
| Dosage: | 10 mg/kg, 100 mg/kg |
| Administration: | Oral administration; daily; for 8 weeks |
| Result: | Attenuated dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid. |
storage
Store at -20°C
FRESELESTAT Preparation Products And Raw materials
Raw materials
Preparation Products
FRESELESTAT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2990 | 60 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| Career Henan Chemica Co | 58 |
| InvivoChem | 58 |
| TargetMol Chemicals Inc. | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
| Amadis Chemical Company Limited | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 55 |
| AdooQ BioScience, LLC | 58 |
| AdooQ Bioscience CHINA | 60 |