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4-Chloro-3-hydroxy-benzoic acid methyl ester

4-Chloro-3-hydroxy-benzoic acid methyl ester structure

CAS No.: 166272-81-7

Chemical Name:: 4-Chloro-3-hydroxy-benzoic acid methyl ester

Synonyms: 4-Chloro-3-hydroxy-benzoic acid methyl ester;Benzoic acid, 4-chloro-3-hydroxy-, methyl ester

CBNumber:: CB12458352

Molecular Formula:: C8H7ClO3

Molecular Weight:: 186.59

MDL Number:: MFCD11505968

MOL File:: 166272-81-7.mol

MSDS File:: SDS

Last updated:2026-09-12 18:49:06

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4-Chloro-3-hydroxy-benzoic acid methyl ester Properties

Melting point	100-101 °C
Boiling point	288.3±20.0 °C(Predicted)
Density	1.354±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	7.68±0.10(Predicted)
Appearance	Light brown to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2918290090

4-Chloro-3-hydroxy-benzoic acid methyl ester price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FC76172	4-Chloro-3-hydroxybenzoic acid methyl ester	166272-81-7	5g	$204.2	2026-06-04	Buy
Biosynth	FC76172	4-Chloro-3-hydroxybenzoic acid methyl ester	166272-81-7	10g	$362.9	2026-06-04	Buy
Apolloscientific	OR907859	Methyl 4-chloro-3-hydroxybenzoate 95%	166272-81-7	100mg	$41	2026-06-04	Buy
Apolloscientific	OR907859	Methyl 4-chloro-3-hydroxybenzoate 95%	166272-81-7	250mg	$56	2026-06-04	Buy
Apolloscientific	OR907859	Methyl 4-chloro-3-hydroxybenzoate 95%	166272-81-7	500mg	$78	2026-06-04	Buy

Product number	Packaging	Price	Buy
FC76172	5g	$204.2	Buy
FC76172	10g	$362.9	Buy
OR907859	100mg	$41	Buy
OR907859	250mg	$56	Buy
OR907859	500mg	$78	Buy

4-Chloro-3-hydroxy-benzoic acid methyl ester Chemical Properties,Uses,Production

Uses

4-Chloro-3-hydroxybenzoic Acid Methyl Ester id used in the synthesis of antidepressants.

Synthesis

67-56-1

34113-69-4

4-CHLORO-3-HYDROXY-BENZOIC ACID METHYL ESTER

166272-81-7

The general procedure for the synthesis of methyl 3-hydroxy-4-chlorobenzoate from methanol and 4-chloro-3-hydroxybenzoic acid was as follows: thionyl chloride (6 g) was added slowly and dropwise to a methanol (100 mL) solution of 4-chloro-3-hydroxybenzoic acid (4.4 g, 25.50 mmol). The reaction mixture was stirred at 70 °C for 2 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure to remove the solvent. The concentrated residue was diluted by adding hexane (50 mL) to the concentrated residue. The precipitated solid product was collected by filtration and dried in an oven under reduced pressure to afford methyl 3-hydroxy-4-chlorobenzoate as a light yellow solid (4 g, 84% yield). The product was analyzed by LC/MS (electrospray ionization, m/z): [M+H]+ 187.0. 1H NMR (300 MHz, DMSO-d6) δ 10.69 (s, 1H, OH), 7.55 (d, J=2.10 Hz, 1H, ArH), 7.49 (d, J=8.40 Hz, 1H, ArH), 7.36-7.40 ( m, 1H, ArH), 3.83-3.85 (d, J=8.40Hz, 3H, OCH3).

References

[1] Chemical and Pharmaceutical Bulletin, 1994, vol. 42, # 11, p. 2365 - 2369
[2] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 3141 - 3147
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 9, p. 3290 - 3312
[5] Patent: EP2048140, 2009, A1. Location in patent: Page/Page column 25

4-Chloro-3-hydroxy-benzoic acid methyl ester Preparation Products And Raw materials

Raw materials

2-Chloro-5-(methoxycarbonyl)benzeneboronic acid 98 Methanol 4-Chloro-3-hydroxybenzoic acid 2-Chloro-5-(trifluoromethyl)phenol

Preparation Products

4-Chloro-3-hydroxy-benzoic acid methyl ester Suppliers

Global( 57)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shanghai Raise Chemical Technology Co.,Ltd	+86-021-50935922		China	7854	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9331	58
Accela ChemBio Inc.	+1(858) 699-3322	marketing@accelachem.com	United States	6022	65
JW & Y Pharmlab Co., Ltd.	021-64340559	xinyu_shi@jwypharmlab.com.cn	China	11999	58
SuZhou ShiYa Biopharmaceuticals, Inc.	0512-0512-52358471 17715136450	sales@shiyabiopharm.com	China	9814	58
Shanghai Qing Cang Chemical Technology Co., Ltd.	00000000000	sales@qingcangchem.com	China	508	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Shanghai Hanhong Scientific Co.,Ltd.	64
Shanghai Raise Chemical Technology Co.,Ltd	55
Bide Pharmatech Ltd.	60
Finetech Industry Limited	58
Accela ChemBio Inc.	65
JW & Y Pharmlab Co., Ltd.	58
SuZhou ShiYa Biopharmaceuticals, Inc.	58
Shanghai Qing Cang Chemical Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60

4-Chloro-3-hydroxy-benzoic acid methyl ester Spectrum

4-CHLORO-3-HYDROXY-BENZOIC ACID METHYL ESTER(166272-81-7)¹HNMR

166272-81-7(4-Chloro-3-hydroxy-benzoic acid methyl ester)Related Search:

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Benzoic acid, 4-chloro-3-hydroxy-, methyl ester 4-Chloro-3-hydroxy-benzoic acid methyl ester 166272-81-7