4-Chloro-3-hydroxybenzoic acid
- CAS No.
- 34113-69-4
- Chemical Name:
- 4-Chloro-3-hydroxybenzoic acid
- Synonyms
- TIMTEC-BB SBB008503;5-Carboxy-2-chlorophenol;4-chloro-3-hydroxybenzoicaci;4-CHLORO-3-HYDROXYBENZOIC ACID;Benzoic acid, 4-chloro-3-hydroxy-;4-Chloro-3-hydroxybenzoic Acid, 97+%;4-CHLORO-3-HYDROXYBENZOIC ACID ---PURITY 98%---
- CBNumber:
- CB4368988
- Molecular Formula:
- C7H5ClO3
- Molecular Weight:
- 172.57
- MDL Number:
- MFCD00153892
- MOL File:
- 34113-69-4.mol
- MSDS File:
- SDS
| Melting point | 219.5-220.5 °C |
|---|---|
| Boiling point | 345.4±27.0 °C(Predicted) |
| Density | 1.536±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | 3.85±0.10(Predicted) |
| color | Light Beige |
| InChI | InChI=1S/C7H5ClO3/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,9H,(H,10,11) |
| InChIKey | SCPUNJAMWFAYED-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(Cl)C(O)=C1 |
| CAS DataBase Reference | 34113-69-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 4-chloro-3-hydroxy-(34113-69-4) |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| target organs | Respiratory system |
| Hazard Codes | Xi |
| WGK Germany | WGK 3 |
| Hazard Note | Irritant |
| HS Code | 2918199890 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Acute 1 Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
4-Chloro-3-hydroxybenzoic acid price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS31248 | 4-Chloro-3-hydroxybenzoic acid 97% | 34113-69-4 | 1g | $24 | 2026-06-04 | Buy |
| Activate Scientific | AS31248 | 4-Chloro-3-hydroxybenzoic acid 97% | 34113-69-4 | 5g | $54 | 2026-06-04 | Buy |
| Activate Scientific | AS31248 | 4-Chloro-3-hydroxybenzoic acid 97% | 34113-69-4 | 25g | $137 | 2026-06-04 | Buy |
| Activate Scientific | AS31248 | 4-Chloro-3-hydroxybenzoic acid 97% | 34113-69-4 | 100g | $541 | 2026-06-04 | Buy |
| Apolloscientific | OR6115 | 4-Chloro-3-hydroxybenzoic acid 98% | 34113-69-4 | 250mg | $21 | 2026-06-04 | Buy |
4-Chloro-3-hydroxybenzoic acid Chemical Properties, Uses, Production
Uses
4-Chloro-3-hydroxy-Benzoic Acid acts as a potential inhibitor of influenza endonuclease used in the treatment of influenza. Also used in the synthesis of highly selective Tie-2 kinase inhibitors used in the treatment of tumors.
Synthesis
931409-94-8
34113-69-4
General procedure for the synthesis of 4-chloro-3-hydroxybenzoic acid from compound (CAS: 931409-94-8): boron tribromide (1 M in dichloromethane, 31 mL, 31.504 mmol) was slowly added dropwise to a solution of compound 38 (3.56 g, 15.752 mmol) in dichloromethane (30 mL) under ice bath cooling conditions. The reaction mixture was stirred at 0°C to room temperature for 18 hours. Upon completion of the reaction, the reaction was quenched with 0.88 aqueous ammonia solution and stirring was continued for 90 minutes at room temperature. Subsequently, the reaction mixture was acidified to pH 1 by dropwise addition of 2N aqueous hydrochloric acid solution and then extracted with ether (2 x 50 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 4-chloro-3-hydroxybenzoic acid as a light yellow solid in 90% yield (2.45 g). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 7.36-7.38 (d, 1H), 7.44-7.47 (dd, 1H), 7.54-7.55 (d, 1H); LRMS APCI m/z 171 [M-H]-.
References
[1] Patent: WO2007/34325, 2007, A1. Location in patent: Page/Page column 53
4-Chloro-3-hydroxybenzoic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Paulshine Chemical Co., Ltd. | +86-021-37788663 | China | 186 | 64 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from 4-Chloro-3-hydroxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-01 | 4-Chloro-3-hydroxybenzoic acid
34113-69-4
|
$3.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 4-Chloro-3-hydroxybenzoic acid
34113-69-4
- $3.00
- 98%
- Career Henan Chemical Co
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