2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
- CAS No.
- 408492-27-3
- Chemical Name:
- 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
- Synonyms
- 2,6-dichloropyridine-4-borate frequency;2,6-dichloropyridine-4-boronic acidolester;2,6-Dichloropyridine-4-boronic acid,pinacol ester;2,6-Dichloropyridinyl-4-boronic acid pinacol ester;(2,6-DICHLOROPYRIDIN-4-YL)BORONIC ACID PINACOL ESTER;2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);2,6-DICHLORO-4-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;2-(2,6-Dichloro-4-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;Pyridine, 2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber:
- CB12459531
- Molecular Formula:
- C11H14BCl2NO2
- Molecular Weight:
- 273.95
- MDL Number:
- MFCD09746195
- MOL File:
- 408492-27-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2,6-Dichloropyridinyl-4-boronic acid pinacol ester 95% | 739111 | 1g | $106 |
| 2,6-Dichloropyridinyl-4-boronic acid pinacol ester 95% | 739111 | 250mg | $34.3 |
| 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC) | D5574 | 1g | $45 |
| 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC) | D5574 | 5g | $154 |
| 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98% | OR42235 | 1g | $21 |
| Melting point | 117-119°C |
|---|---|
| Boiling point | 373.2±42.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | powder to crystal |
| pka | -3.74±0.10(Predicted) |
| color | White to Almost white |
| InChI | 1S/C11H14BCl2NO2/c1-10(2)11(3,4)17-12(16-10)7-5-8(13)15-9(14)6-7/h5-6H,1-4H3 |
| InChIKey | PEFDHAOFDBNZEQ-UHFFFAOYSA-N |
| SMILES | CC1(C)OB(OC1(C)C)c2cc(Cl)nc(Cl)c2 |
| CAS DataBase Reference | 408492-27-3 |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 739111 | 2,6-Dichloropyridinyl-4-boronic acid pinacol ester 95% | 408492-27-3 | 1g | $106 | 2023-06-20 | Buy |
| Sigma-Aldrich | 739111 | 2,6-Dichloropyridinyl-4-boronic acid pinacol ester 95% | 408492-27-3 | 250mg | $34.3 | 2022-05-15 | Buy |
| TCI Chemical | D5574 | 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC) | 408492-27-3 | 1g | $45 | 2026-04-30 | Buy |
| TCI Chemical | D5574 | 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC) | 408492-27-3 | 5g | $154 | 2026-04-30 | Buy |
| Apolloscientific | OR42235 | 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98% | 408492-27-3 | 1g | $21 | 2026-06-04 | Buy |
2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Chemical Properties,Uses,Production
Uses
2,6-Dichloropyridine-4-boronic acid, pinacol ester
Synthesis
2402-78-0
73183-34-3
408492-27-3
General procedure for the synthesis of 2,6-dichloropyridine-4-boronic acid pinacol ester from 2,6-dichloropyridine and bis-boronic acid pinacol ester: Under nitrogen protection, 2,6-dichloropyridine (3 g, 20.3 mmol), 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl (5.92 g, 23.3 mmol), 1,10-phenanthroline (145 mg, 0.81 mmol) and chlorobis(1,5-cyclooctadiene)iridium(I) dimer (267 mg, 0.30 mmol) were dissolved in 1,2-dichloroethane (20 mL). After passing nitrogen for 5 minutes, the reaction mixture was heated at 100 °C for 1 hour. Upon completion of the reaction, the cooled mixture was poured into a mixture of ether (150 mL) and 4 M aqueous sodium hydroxide (200 mL) to separate the organic and aqueous phases. The aqueous phase was cooled with an ice bath and acidified with 5 M aqueous hydrochloric acid, and the resulting precipitate was filtered, washed with water and dried to afford 2,6-dichloropyridine-4-boronic acid pinacol ester (4.9 g, 17.9 mmol, 88% yield).LCMS (Method A): retention time 0.74 min; m/z 192,194 (as MH+ for boronic acid ionization).1H NMR ( 400 MHz, DMSO-d6) δ 1.28 (12H, s), 7.57 (2H, s).
References
[1] Organic Letters, 2009, vol. 11, # 16, p. 3586 - 3589
[2] Journal of the American Chemical Society, 2015, vol. 137, # 25, p. 8058 - 8061
[3] Organic and Biomolecular Chemistry, 2014, vol. 12, # 37, p. 7318 - 7327
[4] Patent: WO2011/110575, 2011, A1. Location in patent: Page/Page column 73
[5] Journal of the American Chemical Society, 2018, vol. 140, # 49, p. 17197 - 17202
2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10817 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23504 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9897 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | sale03@alfachem.cn | China | 9816 | 58 |
View Lastest Price from 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-17 | 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
408492-27-3
|
$1.10-36.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-11-18 | 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
408492-27-3
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-01-09 | 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
408492-27-3
|
$5.50 | 1KG | 98%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
408492-27-3
- $1.10-36.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
408492-27-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
408492-27-3
- $5.50
- 98%-99%
- Career Henan Chemical Co
