6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one
- CAS No.
- 1004294-80-7
- Chemical Name:
- 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one
- Synonyms
- 1-Isoindolinone-6-boronic acid pinacol ester;isoindolin-1-one-6-boronic acid pinacol ester;(3-OXOISOINDOLIN-5-YL)BORONIC ACID PINACOL ESTER;(3-Oxo-5-isoindolinyl)boronic Acid Pinacol Ester;1-Oxo-2,3-dihydro-isoindole-6-boronic acid picol ester;1-Oxo-2,3-dihydro-isoindole-6-boronic acid pinacol ester;6-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)isoindolin-1-one;2,3-Dihydro-1H-isoindol-1-one-6-boronic acid pinacol ester;2,3-dihydro-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;(2,3-Dihydro-3-oxo-1H-isoindol-5-yl)boronic acid, pinacol ester
- CBNumber:
- CB12470488
- Molecular Formula:
- C14H18BNO3
- Molecular Weight:
- 259.11
- MDL Number:
- MFCD11849992
- MOL File:
- 1004294-80-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933998090 |
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR305287 | (2,3-Dihydro-3-oxo-1H-isoindol-5-yl)boronic acid, pinacol ester 95% | 1004294-80-7 | 100mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR305287 | (2,3-Dihydro-3-oxo-1H-isoindol-5-yl)boronic acid, pinacol ester 95% | 1004294-80-7 | 250mg | $29 | 2026-06-04 | Buy |
| Apolloscientific | OR305287 | (2,3-Dihydro-3-oxo-1H-isoindol-5-yl)boronic acid, pinacol ester 95% | 1004294-80-7 | 1g | $64 | 2026-06-04 | Buy |
| Apolloscientific | OR305287 | (2,3-Dihydro-3-oxo-1H-isoindol-5-yl)boronic acid, pinacol ester 95% | 1004294-80-7 | 5g | $309 | 2026-06-04 | Buy |
| Apolloscientific | OR305287 | (2,3-Dihydro-3-oxo-1H-isoindol-5-yl)boronic acid, pinacol ester 95% | 1004294-80-7 | 25g | $1480 | 2026-06-04 | Buy |
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one Chemical Properties, Uses, Production
Synthesis
675109-26-9
73183-34-3
1004294-80-7
General procedure for the synthesis of 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one from 6-bromo-2,3-dihydro-isoindol-1-one and pinacol bis(boronic acid) ester: to a solution of 6-bromo-2,3-dihydro-isoindol-1-one (1 eq.) in anhydrous dioxane (0.1 M) was added bis (pinacol) diboron (1.1 eq.), potassium acetate (3.5 eq.) and 1,1'-bis(diphenylphosphino)ferrocene (dppf, 0.05 eq.). The reaction mixture was degassed with nitrogen for 20 minutes. Subsequently, dichloro(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) (PdCl2(dppf), 0.05 eq.) was added and the mixture was degassed again for 5 minutes. Under nitrogen protection, the reaction mixture was heated to 70 °C for 2 hours and then warmed to 120 °C to continue the reaction for 16 hours. After completion of the reaction, the mixture was partitioned between ethyl acetate (EtOAc) and water. The aqueous phase was further extracted with ethyl acetate, the organic phases were combined, dried with magnesium sulfate (MgSO4), filtered and concentrated in vacuum. The residue was sonicated with ethyl acetate and the suspension was filtered through a sintered funnel, the collected gray solid was dried and used directly in the next reaction without further purification. The yield of the product 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one was 82% with a purity of 29%, and the main impurity was boric acid.LC-MS (ESP) analysis showed m/z: 519.5 [2M + H]+ with a retention time (R/T) of 3.38 minutes.
References
[1] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 117
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 23, p. 9542 - 9555
[3] Patent: WO2017/107089, 2017, A1. Location in patent: Page/Page column 37; 38
[4] Patent: WO2017/68412, 2017, A1. Location in patent: Page/Page column 208; 209
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 11, p. 4978 - 4992
6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| QINGDAO CARELONGPHARMATECH CO.,LTD | 053288191853 13061484198 | sales@carelongchem.com | China | 455 | 57 |
| Sphinx Scientific Laboratory (Tianjin) Co., Ltd. | 022-66211289-843 13672102692 | contact@sphinxpharm.com | China | 361 | 62 |
| Acorn PharmaTech Co., Ltd. | 025-58395930 | sales@acornpharma.com | China | 982 | 60 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai potentpharm CO.,Ltd | (86) 21 51969655 | China | 486 | 22 |
View Latest Price from 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-13 | 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one
1004294-80-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one
1004294-80-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one
1004294-80-7
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one
1004294-80-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one
1004294-80-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one
1004294-80-7
- $1.00
- 99%
- Career Henan Chemical Co
