2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one
![2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one Structure](CAS/20150408/GIF/1313399-38-0.gif)
- CAS No.
- 1313399-38-0
- Chemical Name:
- 2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one
- Synonyms
- (2-METHYL-3-OXOISOINDOLIN-5-YL)BORONIC ACID PINACOL ESTER;2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-isoindol-1-one;2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one;2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindol-1-one;1H-Isoindol-1-one, 2,3-dihydro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber:
- CB72663789
- Molecular Formula:
- C15H20BNO3
- Molecular Weight:
- 273.14
- MDL Number:
- MFCD12755781
- MOL File:
- 1313399-38-0.mol
- MSDS File:
- SDS
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| Appearance | Off-white to pink Solid |
| InChI | InChI=1S/C15H20BNO3/c1-14(2)15(3,4)20-16(19-14)11-7-6-10-9-17(5)13(18)12(10)8-11/h6-8H,9H2,1-5H3 |
| InChIKey | VBWYOZWWAKZWKG-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC(B3OC(C)(C)C(C)(C)O3)=C2)CN1C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 189808 | 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | 1313399-38-0 | 250.00mg | $26 | 2026-05-18 | Buy |
| Matrix Scientific | 189808 | 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | 1313399-38-0 | 1.00g | $103 | 2026-05-18 | Buy |
| Matrix Scientific | 189808 | 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one | 1313399-38-0 | 5.00g | $503 | 2026-05-18 | Buy |
| Synthonix | M58377 | 2-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one 97% | 1313399-38-0 | 100mg | $23 | 2026-05-06 | Buy |
| Synthonix | M58377 | 2-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one 97% | 1313399-38-0 | 250mg | $30 | 2026-05-06 | Buy |
2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one Chemical Properties, Uses, Production
Synthesis
1254319-51-1
73183-34-3
![2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one](/CAS/20150408/GIF/1313399-38-0.gif)
1313399-38-0
N-methyl-6-bromoisoindolin-1-one (723 mg, 3.41 mmol) and pinacol ester of bisboronic acid (1.04 g, 4.09 mmol) were added with potassium acetate (1.00 g, 10.2 mmol) and PdCl2 (dppf) catalyst (139 mg, 0.17 mmol) and the reaction system was sealed under nitrogen protection. DMSO (15 mL) was added to the reaction mixture and the reaction was stirred at 90 °C for 5 hours. After completion of the reaction, it was cooled to room temperature, the reaction mixture was diluted with water (250 mL) and extracted with dichloromethane (5 x 50 mL). The organic phases were combined, washed sequentially with water (2×100 mL) and brine (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude product. Purification by silica gel fast column chromatography (eluent 20% THF/dichloromethane) afforded the target product 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one as a crystalline beige solid (262 mg, 28% yield).NMR [400 MHz, (CD3)2SO] δ 7.91 (br s, 1H), 7.85 (dd, J = 7.6, 1.0 Hz, 1H), 7.59 (dd, J = 7.5, 0.6 Hz, 1H), 4.49 (s, 2H), 3.07 (s, 3H), 1.32 (s, 12H). lRMS (APCI+) m/z Calculated value C15H21Br3O3 [M+H]+ 274, measured value 274.
References
[1] Patent: WO2011/75784, 2011, A1. Location in patent: Page/Page column 113-114
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 23, p. 9542 - 9555
[3] Patent: WO2017/107089, 2017, A1. Location in patent: Page/Page column 37; 38
2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| QINGDAO CARELONGPHARMATECH CO.,LTD | 053288191853 13061484198 | sales@carelongchem.com | China | 455 | 57 |
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| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai QianYan Bio-technology Co., Ltd | 02781293128 | orders@biochemsafebuy.com | China | 9904 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Chengdu Saiousi Pharmaceutical Co., Ltd | 028-64971018 18108168130 | China | 1780 | 55 | |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22344 | 58 |
1313399-38-0 (2-Methyl-6-(4,4,5,5-tetraMethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one) Related Search:
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