Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3-Chloro-5H-pyrrolo[2,3-b]pyrazine

3-Chloro-5H-pyrrolo[2,3-b]pyrazine

3-Chloro-5H-pyrrolo[2,3-b]pyrazine Structure
3-Chloro-5H-pyrrolo[2,3-b]pyrazine structure
CAS No.
1111638-10-8
Chemical Name:
3-Chloro-5H-pyrrolo[2,3-b]pyrazine
Synonyms
3-Chloro-5H-pyrrolo[2,3-b]pyrazine;5H-Pyrrolo[2,3-b]pyrazine, 3-chloro-
CBNumber:
CB12489969
Molecular Formula:
C6H4ClN3
Molecular Weight:
153.57
MDL Number:
MFCD12024539
MOL File:
1111638-10-8.mol
MSDS File:
SDS
Last updated:2026-05-27 23:15:33
Product description Number Pack Size Price
3-Chloro-5H-pyrrolo[2,3-b]pyrazine 006694 100mg $475
3-Chloro-5H-pyrrolo[2,3-b]pyrazine 97% OR932970 100mg $21
3-Chloro-5H-pyrrolo[2,3-b]pyrazine 97% OR932970 250mg $29
3-Chloro-5H-pyrrolo[2,3-b]pyrazine 97% OR932970 1g $73
3-Chloro-5H-pyrrolo[2,3-b]pyrazine 97% OR932970 5g $307
More product size
Request For Quotation

3-Chloro-5H-pyrrolo[2,3-b]pyrazine Properties

Density 1.531
storage temp. 2-8°C
pka 10+-.0.50(Predicted)
Appearance Off-white to yellow Solid
InChI InChI=1S/C6H4ClN3/c7-5-3-9-4-1-2-8-6(4)10-5/h1-3H,(H,8,10)
InChIKey QWTQGZAUKADLTO-UHFFFAOYSA-N
SMILES C12NC=CC1=NC=C(Cl)N=2

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
HS Code  2933998090

3-Chloro-5H-pyrrolo[2,3-b]pyrazine price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 006694 3-Chloro-5H-pyrrolo[2,3-b]pyrazine 1111638-10-8 100mg $475 2026-06-03 Buy
Apolloscientific OR932970 3-Chloro-5H-pyrrolo[2,3-b]pyrazine 97% 1111638-10-8 100mg $21 2026-06-04 Buy
Apolloscientific OR932970 3-Chloro-5H-pyrrolo[2,3-b]pyrazine 97% 1111638-10-8 250mg $29 2026-06-04 Buy
Apolloscientific OR932970 3-Chloro-5H-pyrrolo[2,3-b]pyrazine 97% 1111638-10-8 1g $73 2026-06-04 Buy
Apolloscientific OR932970 3-Chloro-5H-pyrrolo[2,3-b]pyrazine 97% 1111638-10-8 5g $307 2026-06-04 Buy
Product number Packaging Price Buy
006694 100mg $475 Buy
OR932970 100mg $21 Buy
OR932970 250mg $29 Buy
OR932970 1g $73 Buy
OR932970 5g $307 Buy

3-Chloro-5H-pyrrolo[2,3-b]pyrazine Chemical Properties,Uses,Production

Uses

3-Chloro-5H-pyrrolo[2,3-b]pyrazine is used in the preparation of pyrazole compounds as Raf inhibitors.

Synthesis

6-Chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine

1111638-09-5

3-Chloro-5H-pyrrolo[2,3-b]pyrazine

1111638-10-8

Step 3: A solution of 6-chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine (6.0 g, 26.57 mmol) in anhydrous THF (130 mL) was cooled to 0°C. In another vessel, potassium tert-butanolate (tBuOK, 5.96 g, 53.15 mmol) was suspended in THF (30 mL). This suspension was slowly added to the previously cooled solution. The reaction mixture was stirred at 0 °C for 30 min and then warmed up to reflux state for 2.5 h of reaction. The progress of the reaction was monitored by thin layer chromatography (TLC, 30% ethyl acetate/hexane) to confirm complete consumption of the feedstock. Upon completion of the reaction, the mixture was cooled to 25 °C and filtered through a bed of diatomaceous earth to remove insoluble impurities. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was further purified by column chromatography on silica gel (100-200 mesh) using ethyl acetate/hexane (25:60) as eluent to afford the final brown solid product 3-chloro-5H-pyrrolo[2,3-b]pyrazine (2.51 g, 61% yield). Mass spectrometry (MS) analysis showed m/z(ES): 154(M+H)+.

References

[1] Patent: US2011/59118, 2011, A1. Location in patent: Page/Page column 88-89
[2] Patent: WO2016/203404, 2016, A1. Location in patent: Paragraph 00336

3-Chloro-5H-pyrrolo[2,3-b]pyrazine Preparation Products And Raw materials

Raw materials

6-Chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine Potassium tert-butoxide tert-Butanol Potassium Recombinant Human Telomerase
Tetrahydrofuran

1of2

Preparation Products

5H-Pyrrolo[2,3-b]pyrazine, 3-chloro-5-Methyl-

3-Chloro-5H-pyrrolo[2,3-b]pyrazine Suppliers

Global( 112)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32998 60
Accela ChemBio Inc. 		+1-858-6993322 +86-18019713315 info@accelachem.com United States 21189 58
Shanghai Worldyang Chemical Co.,Ltd. 		+86-021-56795779 +86-13651600618 sales@worldyachem.com China 963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Fuxin Pharmaceutical 		+86-021-021-50872116 contact@fuxinpharm.com China 9976 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9040 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 17705817739 info@dycnchem.com China 52693 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Accela ChemBio Inc. 		58
Shanghai Worldyang Chemical Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Fuxin Pharmaceutical 		58
Baoji Guokang Healthchem Co., Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from 3-Chloro-5H-pyrrolo[2,3-b]pyrazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloro-5H-pyrrolo[2,3-b]pyrazine pictures 2021-07-13 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
1111638-10-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
3-Chloro-5H-pyrrolo[2,3-b]pyrazine pictures 2020-01-01 3-Chloro-5H-pyrrolo[2,3-b]pyrazine
1111638-10-8
 $1.00 1KG 99% 200kg Career Henan Chemical Co

3-Chloro-5H-pyrrolo[2,3-b]pyrazine Spectrum

3-Chloro-5H-pyrrolo[2,3-b]pyrazine(1111638-10-8)1HNMR

1111638-10-8(3-Chloro-5H-pyrrolo[2,3-b]pyrazine)Related Search:

PYRIDO[3,4-B]PYRAZINE, 7-CHLORO- 8-Chloro-pyrido[3,4-b]pyrazine Belvarafenib 2,3-dichloropyrido[3,4-b]pyrazine 5-Bromo-1,4,6-triazanaphthalene
5,7-Dichloropyrido[4,3-b]pyrazine Pyrido[3,4-b]pyrazine, 7-amino- (7CI) 5-CHLOROPYRIDO[4,3-B]PYRAZINE 8-Bromo-pyrido[3,4-b]pyrazine BMS 777607
7-bromopyrido[3,4-b]pyrazine PYRIDO[4,3-B]PYRAZIN-5-AMINE 3-Bromo-5H-pyrrolo[2,3-b]... 5-Bromo-4,7-diazaindole

1of3

5H-Pyrrolo[2,3-b]pyrazine, 3-chloro- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine 1111638-10-8 Aromatics Bases & Related Reagents Heterocycles Inhibitors Nucleotides