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3-Chloro-5H-pyrrolo[2,3-b]pyrazine

3-Chloro-5H-pyrrolo[2,3-b]pyrazine structure

CAS No.: 1111638-10-8

Chemical Name:: 3-Chloro-5H-pyrrolo[2,3-b]pyrazine

Synonyms: 3-Chloro-5H-pyrrolo[2,3-b]pyrazine;5H-Pyrrolo[2,3-b]pyrazine, 3-chloro-

CBNumber:: CB12489969

Molecular Formula:: C6H4ClN3

Molecular Weight:: 153.57

MDL Number:: MFCD12024539

MOL File:: 1111638-10-8.mol

MSDS File:: SDS

Last updated:2025-10-14 17:28:45

Product description	Number	Pack Size	Price
3-Chloro-5H-pyrrolo[2,3-b]pyrazine	C380400	500mg	$170
3-Chloro-5H-pyrrolo[2,3-b]pyrazine	006694	100mg	$475
3-Chloro-5H-pyrrolo[2,3-b]pyrazine 98%	OR932970	250mg	$261
3-Chloro-5H-pyrrolo[2,3-b]pyrazine	2047AA	250mg	$181
3-Chloro-5H-pyrrolo[2,3-b]pyrazine 98%	OR932970	1g	$595
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3-Chloro-5H-pyrrolo[2,3-b]pyrazine Properties

Density	1.531
storage temp.	2-8°C
pka	10?+-.0.50(Predicted)
Appearance	Off-white to yellow Solid
InChI	InChI=1S/C6H4ClN3/c7-5-3-9-4-1-2-8-6(4)10-5/h1-3H,(H,8,10)
InChIKey	QWTQGZAUKADLTO-UHFFFAOYSA-N
SMILES	C12NC=CC1=NC=C(Cl)N=2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
HS Code	2933998090

3-Chloro-5H-pyrrolo[2,3-b]pyrazine price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C380400	3-Chloro-5H-pyrrolo[2,3-b]pyrazine	1111638-10-8	500mg	$170	2021-12-16	Buy
Usbiological	006694	3-Chloro-5H-pyrrolo[2,3-b]pyrazine	1111638-10-8	100mg	$475	2021-12-16	Buy
Apolloscientific	OR932970	3-Chloro-5H-pyrrolo[2,3-b]pyrazine 98%	1111638-10-8	250mg	$261	2021-12-16	Buy
AK Scientific	2047AA	3-Chloro-5H-pyrrolo[2,3-b]pyrazine	1111638-10-8	250mg	$181	2021-12-16	Buy
Apolloscientific	OR932970	3-Chloro-5H-pyrrolo[2,3-b]pyrazine 98%	1111638-10-8	1g	$595	2021-12-16	Buy

Product number	Packaging	Price	Buy
C380400	500mg	$170	Buy
006694	100mg	$475	Buy
OR932970	250mg	$261	Buy
2047AA	250mg	$181	Buy
OR932970	1g	$595	Buy

3-Chloro-5H-pyrrolo[2,3-b]pyrazine Chemical Properties,Uses,Production

Uses

3-Chloro-5H-pyrrolo[2,3-b]pyrazine is used in the preparation of pyrazole compounds as Raf inhibitors.

Synthesis

6-Chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine

1111638-09-5

1111638-10-8

Step 3: A solution of 6-chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine (6.0 g, 26.57 mmol) in anhydrous THF (130 mL) was cooled to 0°C. In another vessel, potassium tert-butanolate (tBuOK, 5.96 g, 53.15 mmol) was suspended in THF (30 mL). This suspension was slowly added to the previously cooled solution. The reaction mixture was stirred at 0 °C for 30 min and then warmed up to reflux state for 2.5 h of reaction. The progress of the reaction was monitored by thin layer chromatography (TLC, 30% ethyl acetate/hexane) to confirm complete consumption of the feedstock. Upon completion of the reaction, the mixture was cooled to 25 °C and filtered through a bed of diatomaceous earth to remove insoluble impurities. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was further purified by column chromatography on silica gel (100-200 mesh) using ethyl acetate/hexane (25:60) as eluent to afford the final brown solid product 3-chloro-5H-pyrrolo[2,3-b]pyrazine (2.51 g, 61% yield). Mass spectrometry (MS) analysis showed m/z(ES): 154(M+H)+.

References

[1] Patent: US2011/59118, 2011, A1. Location in patent: Page/Page column 88-89
[2] Patent: WO2016/203404, 2016, A1. Location in patent: Paragraph 00336

3-Chloro-5H-pyrrolo[2,3-b]pyrazine Preparation Products And Raw materials

Raw materials

6-Chloro-3-((trimethylsilyl)ethynyl)pyrazin-2-amine Potassium tert-butoxide tert-Butanol Potassium Recombinant Human Telomerase

Tetrahydrofuran

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Preparation Products

5H-Pyrrolo[2,3-b]pyrazine, 3-chloro-5-Methyl-

3-Chloro-5H-pyrrolo[2,3-b]pyrazine Suppliers

Global( 105)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	970	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29798	58
Baoji Guokang Healthchem Co., Ltd.	+86-0917-3909592 +86-13892490616	gksales1@gk-bio.com	China	9212	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Nanjing Hengbei Chemicals Co., Ltd.	+86-25-58393656	sales@hengbeichem.cn	China	6854	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Shanghai Worldyang Chemical Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Baoji Guokang Healthchem Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Nanjing Hengbei Chemicals Co., Ltd.	58

View Lastest Price from 3-Chloro-5H-pyrrolo[2,3-b]pyrazine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-13	3-Chloro-5H-pyrrolo[2,3-b]pyrazine 1111638-10-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2020-01-01	3-Chloro-5H-pyrrolo[2,3-b]pyrazine 1111638-10-8	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

3-Chloro-5H-pyrrolo[2,3-b]pyrazine
1111638-10-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

3-Chloro-5H-pyrrolo[2,3-b]pyrazine
1111638-10-8
US $1.00 / KG
99%
Career Henan Chemical Co

3-Chloro-5H-pyrrolo[2,3-b]pyrazine Spectrum

3-Chloro-5H-pyrrolo[2,3-b]pyrazine(1111638-10-8)¹HNMR

1111638-10-8(3-Chloro-5H-pyrrolo[2,3-b]pyrazine)Related Search:

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5H-Pyrrolo[2,3-b]pyrazine, 3-chloro- 3-Chloro-5H-pyrrolo[2,3-b]pyrazine 1111638-10-8 Aromatics Bases & Related Reagents Heterocycles Inhibitors Nucleotides