5-Bromo-4,7-diazaindole
- CAS No.
- 875781-43-4
- Chemical Name:
- 5-Bromo-4,7-diazaindole
- Synonyms
- 2-Bromo-5H-pyrrolo[2,3-b]pyrazine;Upatinib Impurity 94;5-BROMO-4,7-DIAZAINDOLE;5-Bromo-4,7-diazaindole 97%;5-Bromo-4,7-diazaindole - [B0088];5H-Pyrrolo[2,3-b]pyrazine, 2-bromo-;4H-Pyrrolo[2,3-b]pyrazine, 2-bromo-;2-broMo-5H-pyrrolo[2,3-b]pyrazine 2-broMo-5H-pyrrolo[3,2-b]pyrazine
- CBNumber:
- CB01012860
- Molecular Formula:
- C6H4BrN3
- Molecular Weight:
- 198.02
- MDL Number:
- MFCD09834822
- MOL File:
- 875781-43-4.mol
- MSDS File:
- SDS
| Boiling point | 265 °C |
|---|---|
| Density | 2.00 |
| Flash point | 114 °C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | yellow solid |
| pka | 10.58±0.50(Predicted) |
| Appearance | Light yellow to brown Solid |
| InChI | InChI=1S/C6H4BrN3/c7-5-3-9-6-4(10-5)1-2-8-6/h1-3H,(H,8,9) |
| InChIKey | KTKMLXBEBKGQGL-UHFFFAOYSA-N |
| SMILES | C12NC=CC1=NC(Br)=CN=2 |
| CAS DataBase Reference | 875781-43-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933998090 |
5-Bromo-4,7-diazaindole price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 52608 | 2-BROMO-5H-PYRROLO[2,3-B]PYRAZINE 97% | 875781-43-4 | 1G | $21 | 2026-04-30 | Buy |
| Apolloscientific | OR323262 | 5-Bromo-4,7-diazaindole 98% | 875781-43-4 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR323262 | 5-Bromo-4,7-diazaindole 98% | 875781-43-4 | 5g | $48 | 2026-06-04 | Buy |
| Apolloscientific | OR323262 | 5-Bromo-4,7-diazaindole 98% | 875781-43-4 | 25g | $236 | 2026-06-04 | Buy |
| Apolloscientific | OR323262 | 5-Bromo-4,7-diazaindole 98% | 875781-43-4 | 100g | $936 | 2026-06-04 | Buy |
5-Bromo-4,7-diazaindole Chemical Properties, Uses, Production
Uses
5-Bromo-4,7-diazaindole is used as an intermediate in organic synthesis and pharmaceuticals.
Synthesis
Potassium tert-butoxide (3.70 g, 33.0 mmol) was dissolved in THF (80 mL) under N2 protection. A solution of 5-bromo-3 - ((trimethylsilyl) ethynyl) pyrazine-2-amino (9.00 g, 33.0 mmol) in THF (84 mL) was slowly added dropwise over 30 min. After the dropwise addition, the mixture was stirred at room temperature for 30 min, Reflux reaction 1h, Cooled to room temperature and filtered. The filter cake was washed with ethyl acetate (200 mL) and saturated brine (50 mL x 2), and the aqueous phase was combined. And extracted with ethyl acetate (60 mL x 2). The organic phases were combined. The residue was subjected to column chromatography (eluent: PE / EtOAc (v / v) = 3/1) to give 5-Bromo-4,7-diazaindole 5.0 g of a yellow solid.
Toxicity evaluation
5-Bromo-4,7-diazaindole has acute oral toxicity.
References
[1] Patent: CN106432246, 2017, A. Location in patent: Paragraph 0543; 0544; 0545
[2] Patent: WO2011/149950, 2011, A2
[3] Patent: WO2012/158785, 2012, A1. Location in patent: Page/Page column 90
[4] Patent: WO2014/81732, 2014, A1. Location in patent: Page/Page column 32
[5] Patent: WO2014/85795, 2014, A1
5-Bromo-4,7-diazaindole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Chemtrue Bio-Tech Co.,Ltd. | 19967494293 | sales@chemtrue-bio.com | China | 303 | 58 |
| Guangzhou Anyanren Pharmaceutical Technology Co., Ltd. | 18028661570 | 2412659056@qq.com | China | 291 | 58 |
| PharmaBlock Sciences (Nanjing), Inc. | 4000255188 13327728092 | sales@pharmablock.com | China | 9999 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 |
View Latest Price from 5-Bromo-4,7-diazaindole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 5-Bromo-4,7-diazaindole
875781-43-4
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 5-Bromo-4,7-diazaindole
875781-43-4
|
1KG | 98 | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 5-Bromo-4,7-diazaindole
875781-43-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- 5-Bromo-4,7-diazaindole
875781-43-4
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 5-Bromo-4,7-diazaindole
875781-43-4
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-Bromo-4,7-diazaindole
875781-43-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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