methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate
![methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Structure](CAS/GIF/26845-47-6.gif)
- CAS No.
- 26845-47-6
- Chemical Name:
- methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate
- Synonyms
- methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate;1,4-Dioxaspiro[4.5]decane-8-carboxylic Acid Methyl Ester
- CBNumber:
- CB12499290
- Molecular Formula:
- C10H16O4
- Molecular Weight:
- 200.23
- MDL Number:
- MFCD13195278
- MOL File:
- 26845-47-6.mol
- MSDS File:
- SDS
| Boiling point | 96-100 °C |
|---|---|
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | clear liquid |
| color | Colorless to Almost colorless |
| CAS DataBase Reference | 26845-47-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H335-H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| HS Code | 2932.99.9090 | |||||||||
| NFPA 704 |
|
methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3273 | Methyl 1,4-Dioxaspiro[4.5]decane-8-carboxylate | 26845-47-6 | 1G | $65 | 2026-04-30 | Buy |
| TCI Chemical | M3273 | Methyl 1,4-Dioxaspiro[4.5]decane-8-carboxylate | 26845-47-6 | 5G | $226 | 2026-04-30 | Buy |
| Matrix Scientific | 132067 | Methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate | 26845-47-6 | 5.00g | $2674 | 2026-05-18 | Buy |
| Matrix Scientific | 132067 | Methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate | 26845-47-6 | 10.00g | $3960 | 2026-05-18 | Buy |
| Synthonix | M37974 | Methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 95+% | 26845-47-6 | 1g | $26 | 2026-05-06 | Buy |
methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Chemical Properties, Uses, Production
Uses
methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate is a reagnet used in the preparation of pharmaceutical compounds such as high affinity H3 receptor agonists and reverse hydroxamate-based selective TACE inhibitors.
Synthesis
6297-22-9
107-21-1
![methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate](/CAS/GIF/26845-47-6.gif)
26845-47-6
Step 1: Synthesis of methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 1.3 g of methyl 4-oxocyclohexanecarboxylate, 0.64 g of ethylene glycol and 0.14 g of p-toluenesulfonic acid were added to 40 mL of toluene. The mixed solution was refluxed and stirred overnight in the presence of a Dean-Stark water separator to remove the water generated. Upon completion of the reaction, the toluene solvent was removed by distillation under reduced pressure. Subsequently, the reaction mixture was separated by extraction with 50 mL of diethyl ether and 50 mL of water. The organic phase was dried with anhydrous magnesium sulfate, filtered and purified by reduced pressure distillation (138~145 °C, 15 mmHg) to afford 0.42 g of the oily target product methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate. The product was characterized by NMR (300 MHz, CDCl3): δ 3.95 (s, 4H), 3.67 (s, 3H), 2.36~2.32 (m, 1H), 1.94~1.91 (m, 2H), 1.83~1.75 (m, 4H), 1.61~1.55 (m, 2H).
References
[1] Journal of Organic Chemistry, 1997, vol. 62, # 16, p. 5284 - 5292
[2] Recueil: Journal of the Royal Netherlands Chemical Society, 1980, vol. 99, # 2, p. 53 - 57
[3] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 23, p. 6309 - 6323
[4] Patent: WO2007/6760, 2007, A1. Location in patent: Page/Page column 109-110; 130-131
[5] Patent: EP1860089, 2007, A1. Location in patent: Page/Page column 21-22
methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Shanghai potentpharm CO.,Ltd | 13524892556 | sales-cn@potentpharm.com | China | 1011 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
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![Methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate pictures](/ProductImageEN1/2025-09/Small/59188363-cf8e-404a-9a20-6d95a512b12f.gif) |
2026-05-18 | Methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate
26845-47-6
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd |
-
- Methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate
26845-47-6
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
