4-methyl-7-nitro-1H-indole-3-carbonitrile
- CAS No.
- 289483-82-5
- Chemical Name:
- 4-methyl-7-nitro-1H-indole-3-carbonitrile
- Synonyms
- 4-methyl-7-nitro-1H-indole-3-carbonitrile;4-methyl-7-nitro-1H-indole-4-carbonitrile;1H-Indole-3-carbonitrile, 4-methyl-7-nitro-
- CBNumber:
- CB12514977
- Molecular Formula:
- C10H7N3O2
- Molecular Weight:
- 201.18
- MDL Number:
- MFCD17779298
- MOL File:
- 289483-82-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
4-methyl-7-nitro-1H-indole-3-carbonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | M53546 | 4-Methyl-7-nitro-1H-indole-3-carbonitrile 95+% | 289483-82-5 | 100mg | $60 | 2026-05-06 | Buy |
| Synthonix | M53546 | 4-Methyl-7-nitro-1H-indole-3-carbonitrile 95+% | 289483-82-5 | 250mg | $70 | 2026-05-06 | Buy |
| Synthonix | M53546 | 4-Methyl-7-nitro-1H-indole-3-carbonitrile 95+% | 289483-82-5 | 1g | $260 | 2026-05-06 | Buy |
| Synthonix | M53546 | 4-Methyl-7-nitro-1H-indole-3-carbonitrile 95+% | 289483-82-5 | 5g | $1280 | 2026-05-06 | Buy |
| aablocks | AA002X2R | 4-Methyl-7-nitro-1H-indole-3-carbonitrile 95% | 289483-82-5 | 100mg | $36 | 2026-05-28 | Buy |
4-methyl-7-nitro-1H-indole-3-carbonitrile Chemical Properties, Uses, Production
Synthesis
289483-80-3
289483-82-5
GENERAL STEPS: To 740 mL of dimethylformamide (DMF) was slowly added 235 mL (2.52 mol) of phosphoryl chloride (POCl3) at 0 °C and the reaction mixture was stirred at 0 °C for 0.5 hours. Subsequently, 370 g (2.10 mol) of 4-methyl-7-nitro-1H-indole (WO00/50395) solution in DMF (1110 mL) was added dropwise to the reaction system at 0 °C. The reaction mixture was gradually warmed to 60 °C and stirred at this temperature for 2 hours. Upon completion of the reaction, 292 g (4.20 mol) of DMF (1850 mL) solution of hydroxylamine hydrochloride was slowly added dropwise to the system, with the dropwise acceleration controlled to keep the internal temperature below 80 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 60 °C for 40 min. Subsequently, the reaction mixture was poured into 11.1 L of ice water while cooling in an ice bath and stirred overnight. The precipitated solid was collected by filtration and washed with water. The resulting solid was suspended in 11.1 L of water and the pH of the suspension was adjusted to 7 with 1 N sodium hydroxide solution, the solid was again collected by filtration and washed with water to give 412 g of 4-methyl-7-nitro-1H-indole-3-carbonitrile (Yield: 97.6%). The resulting product was confirmed to be consistent with 3-cyano-4-methyl-7-nitro-1H-indole described in WO00/50395 by HPLC analysis.HPLC conditions: mobile phase CH3CN/H2O/70% HClO4 = 500/500/1 (v/v/v), flow rate 1.0 mL/min, detection wavelength 254 nm, column YMC- Pack Pro C18 250 x 4.6 mm.
References
[1] Patent: EP1666463, 2006, A1. Location in patent: Page/Page column 9-10
4-methyl-7-nitro-1H-indole-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
4-methyl-7-nitro-1H-indole-3-carbonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Cuisen Pharmaceutical Technology Co., Ltd. | 13472757003 | yongnan.wang@cendrix.cn | China | 974 | 65 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2277 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5971 | 58 |
| Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16103 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Hubei Co-prosperity Medicine Technonlogy Co., Ltd | 2383948258 19172820304 | 2383948258@qq.com | China | 12983 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39796 | 58 |
| Wuhan Augda Biotechnology Co., Ltd | 15071299552 | 262933239@qq.com | China | 7201 | 58 |
