ChemicalBook >> CAS DataBase List >>4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride structure

CAS No.: 388575-52-8

Chemical Name:: 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride

Synonyms: PSN375963;PSN 375963 hydrochloride;PSN 375963, 10 mM in DMSO;5-(4-butylcyclohexyl)-3-pyridin-4-yl-1,2,4-oxadiazole;4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine;Pyridine, 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-;4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride;Inhibitor,inhibit,PSN375963,receptor,PSN 375963,PSN-375963,G Protein-Coupled Receptor 119,endogenous,GPR119,ligand,orphan,cAMP

CBNumber:: CB12518900

Molecular Formula:: C17H23N3O

Molecular Weight:: 285.38

MDL Number:: MFCD01829706

MOL File:: 388575-52-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-11 15:21:01

Product description	Number	Pack Size	Price
PSN-375963 ≥98% (HPLC)	P0028	25mg	$358
PSN375963 ≥98%	10008593	1mg	$20
PSN375963 ≥98%	10008593	5mg	$81
PSN375963 ≥98%	10008593	10mg	$142
PSN375963 ≥98%	10008593	25mg	$306
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4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Properties

Boiling point	440.1±47.0 °C(Predicted)
Density	1.060±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: >10mg/mL
form	powder
pka	0.82±0.10(Predicted)
color	white to off-white
InChI	1S/C17H23N3O/c1-2-3-4-13-5-7-15(8-6-13)17-19-16(20-21-17)14-9-11-18-12-10-14/h9-13,15H,2-8H2,1H3
InChIKey	OAVLEYPTWABFLF-UHFFFAOYSA-N
SMILES	CCCCC1CCC(CC1)c2nc(no2)-c3ccncc3
FDA UNII	C9M28M425E
UNSPSC Code	12352202
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	nwg
Storage Class	11 - Combustible Solids

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P0028	PSN-375963 ≥98% (HPLC)	388575-52-8	25mg	$358	2022-05-15	Buy
Cayman Chemical	10008593	PSN375963 ≥98%	388575-52-8	1mg	$20	2026-04-30	Buy
Cayman Chemical	10008593	PSN375963 ≥98%	388575-52-8	5mg	$81	2026-04-30	Buy
Cayman Chemical	10008593	PSN375963 ≥98%	388575-52-8	10mg	$142	2026-04-30	Buy
Cayman Chemical	10008593	PSN375963 ≥98%	388575-52-8	25mg	$306	2026-04-30	Buy

Product number	Packaging	Price	Buy
P0028	25mg	$358	Buy
10008593	1mg	$20	Buy
10008593	5mg	$81	Buy
10008593	10mg	$142	Buy
10008593	25mg	$306	Buy

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Chemical Properties,Uses,Production

Uses

PSN 375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA)[1][2].

Biochem/physiol Actions

PSN-375963 is a GPR119 partial agonist. GPR119 is an orphan GPCR, expressed predominantly in pancreas and GI tract, that has been characterized. Its endogenous ligands are oleoylethanolamide (OEA) and oleoyl-lysophosphatidylcholine, lipid signaling molecules that regulate food intake and body weight. OEA decreases food intake, so GPR119 agonists are potential therapies for obesity. Initial studies showed that PSN-375963 has similar potency and partial efficacy compared to OEA. Further studies revealed that although OEA and PSN-375963 are GPR119 agonists, they have divergent effects on insulin secretion, calcium signaling, and cAMP production.

References

[1] Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175. DOI:10.1016/j.cmet.2006.02.004
[2] Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155(7):1056-1065. DOI:10.1038/bjp.2008.337

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Suppliers

Global( 54)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Aladdin Scientific		tp@aladdinsci.com	United States	50108	58
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4766	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Angel Pharmatech, Ltd.	17317130613	3358272972@qq.com	China	3307	58
BOC Sciences	--	info@bocsci.com	USA	0	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11123	58
Nantong Feiyu Biological Technology CO.,LTD	0513-68819626 15152877458	feiyubio@163.com	China	4807	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58
Beijing Famozi Pharmaceutical Technology Co., Ltd	15811073878	2559355526@qq.com	China	9993	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Dalian Meilun Biotech Co., Ltd.	58
Sigma-Aldrich	80
Angel Pharmatech, Ltd.	58
BOC Sciences	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Nantong Feiyu Biological Technology CO.,LTD	58
TargetMol Chemicals Inc.	58
Beijing Famozi Pharmaceutical Technology Co., Ltd	58

View Lastest Price from 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	PSN 375963 388575-52-8	$35.00-118.00		99.63%	10g	TargetMol Chemicals Inc.

PSN 375963
388575-52-8
$35.00-118.00
99.63%
TargetMol Chemicals Inc.

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride Spectrum

4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride(388575-52-8)¹HNMR

388575-52-8(4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride)Related Search:

3-(4-BROMOPHENYL)-5-CYCLOHEXYL-1,2,4-OXADIAZOLE 5-Butyl-3-p-tolyl-1,2,4-oxadiazole Phenol, 4-(5-butyl-1,2,4-oxadiazol-3-yl)- 1,2,4-Oxadiazole, 5-cyclopropyl-3-(4-methylphenyl)- 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride

4-[5-(3-CHLOROPROPYL)-1,2,4-OXADIAZOL-3-YL]PYRIDINE

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4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridinehydrochloride PSN 375963 hydrochloride PSN375963 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine 5-(4-butylcyclohexyl)-3-pyridin-4-yl-1,2,4-oxadiazole Inhibitor,inhibit,PSN375963,receptor,PSN 375963,PSN-375963,G Protein-Coupled Receptor 119,endogenous,GPR119,ligand,orphan,cAMP Pyridine, 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]- PSN 375963, 10 mM in DMSO 388575-52-8 C17H23N3OHCl