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5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole

5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole structure

CAS No.: 102625-64-9

Chemical Name:: 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole

Synonyms: PANTOPRAZOLE SULFIDE;Pantoprazole Related CoMpound B;5-(DifluoroMethoxy)-2-(((3,4-diMethoxypyridin-2-yl)Methyl)thio)-1H-benzo[d]iMidazole;Pantoprazole-2;pantoprazole sulphide;Pantoprazole Ep Imp B;Pantoprazole Thioether;PantoprazoleSulfide>5-DifluoroMethoxy-2-[(3;Pantoprazole condensate

CBNumber:: CB1253016

Molecular Formula:: C16H15F2N3O3S

Molecular Weight:: 367.37

MDL Number:: MFCD07368273

MOL File:: 102625-64-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:20:17

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5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Properties

Melting point	110-118°C
Boiling point	526.3±60.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	8.97±0.10(Predicted)
color	Off-White to Light Brown
BRN	5358607
Major Application	pharmaceutical
InChI	InChI=1S/C16H15F2N3O3S/c1-22-13-5-6-19-12(14(13)23-2)8-25-16-20-10-4-3-9(24-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)
InChIKey	UKILEIRWOYBGEJ-UHFFFAOYSA-N
SMILES	C1(SCC2=NC=CC(OC)=C2OC)NC2=CC(OC(F)F)=CC=C2N=1
CAS DataBase Reference	102625-64-9(CAS DataBase Reference)
FDA UNII	BWZ6X03HIB
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

WGK Germany

WGK 3

HS Code

2933399090

Storage Class

11 - Combustible Solids

REACH Registrations

Inactive

NFPA 704

	0
3		0

5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole price More Price(71)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3074	Pantoprazole Related Compound B pharmaceutical secondary standard, certified reference material	102625-64-9	50MG	$382	2026-04-30	Buy
Sigma-Aldrich	1494910	Pantoprazole Related Compound B United States Pharmacopeia (USP) Reference Standard	102625-64-9	25mg	$1390	2026-04-30	Buy
TCI Chemical	P2066	Pantoprazole Sulfide >98.0%(HPLC)(T)	102625-64-9	1g	$25	2026-04-30	Buy
TCI Chemical	P2066	Pantoprazole Sulfide >98.0%(HPLC)(T)	102625-64-9	5g	$76	2026-04-30	Buy
Cayman Chemical	22251	Pantoprazole Sulfide ≥98%	102625-64-9	1g	$36	2026-04-30	Buy

Product number	Packaging	Price	Buy
PHR3074	50MG	$382	Buy
1494910	25mg	$1390	Buy
P2066	1g	$25	Buy
P2066	5g	$76	Buy
22251	1g	$36	Buy

5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Chemical Properties,Uses,Production

Chemical Properties

Beige Solid

Uses

A metabolite of Pantoprazole, an antiulcerative, gastric pump inhibitor

Uses

Pantoprazole Sulfide (Pantoprazole EP Impurity B) is a metabolite of Pantoprazole (P183000), an antiulcerative, gastric pump inhibitor.

Synthesis

2-CHLOROMETHYL-3,4-DIMETHOXY PYRIDINE HYDROCHLORIDE

169905-10-6

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole

97963-62-7

5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole

102625-64-9

[Example 1] Preparation of 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole: 920 mL of isopropanol, 92.1 g of 5-difluoromethoxy-2-mercapto-1H-benzimidazole, and 95.8 g of 2-chloromethyl-3,4-dimethoxypyridine were added to the reactor. Sodium hydroxide solution (prepared by dissolving 20.5 g of sodium hydroxide in 920 mL of pure water) was added slowly and dropwise to the above mixture, followed by stirring the reaction mixture for 2 hours at room temperature. Upon completion of the reaction, 920 mL of pure water was added to the mixture and stirring was continued for 1 hour. The resulting solid product was collected by filtration and dried under vacuum to give 137.4 g of the target compound in 87.8% yield with a melting point of 94 °C.

References

[1] Patent: WO2009/75516, 2009, A2. Location in patent: Page/Page column 4
[2] Organic Process Research and Development, 2013, vol. 17, # 10, p. 1272 - 1276

5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Preparation Products And Raw materials

Raw materials

2-Chloromethyl-3,4-dimethoxy pyridine hydrochloride 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 2-Chloromethyl-3,4-dimethoxypyridinium chloride Isopropyl alcohol

Sodium hydroxide

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Preparation Products

Pantoprazole Sodium

5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Suppliers

Global( 418)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6746	52
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Wuhan Wei Shunda Technology Development Co., Ltd.	86-027-88774375	mwmwhot@163.com	China	233	65

Supplier	Advantage
XiaoGan ShenYuan ChemPharm co,ltd	52
J & K SCIENTIFIC LTD.	76
INTATRADE GmbH	66
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Wuhan Wei Shunda Technology Development Co., Ltd.	65

View Lastest Price from 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-11-23	Pantoprazole sulfide 102625-64-9	$35.00	500KG	≥98%	100tons	Qiuxian Baitai New Material Co., LTD
2021-07-13	Pantoprazole Sulfide 102625-64-9	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Pantoprazole Sulfide 102625-64-9	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Pantoprazole sulfide
102625-64-9
$35.00
≥98%
Qiuxian Baitai New Material Co., LTD

Pantoprazole Sulfide
102625-64-9
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Pantoprazole Sulfide
102625-64-9
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

102625-64-9(5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole)Related Search:

4-Methoxybenzyl alcohol 4-Methoxybenzyl cyanide p-Anisaldehyde Tribenuron methyl p-Anisidine

4-Methoxyphenol Anisole (Trifluoromethoxy)benzene Methyl acetate Kresoxim-methyl

Guaiacol Methyl salicylate Dimethoxymethane Thiophanate-methyl 4-Methoxybenzoic acid

Metsulfuron methyl Pantoprazole sulphone sodium salt 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole

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Pantoprazole Related Compound B (25 mg) (5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole) Pantoprazole Thioether 5-(DIFLUOROMETHOXY)-2-[[3,4-DIMETHOXY-2-PYRIDINYL)-METHYL]-THIO]-1H- BENZIMIDAZOLE (PANTOPRAZOLE SULPHIDE COMPOUND) Pantoprazole Thioether, 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole 5-(Difluoromethoxy)-2-{[3,4-di 5-Difluoromethoxy-2-{[(3,4-dim 5-(DIFLUOROMETHOXY)-2-{[3,4-DIMETHOXY-2-PYRIDINYL)METHYL]THIO}IH- BENZIMIDAZOLE 5-Difluoromethoxy-2-(((3,4-Dimethoxy-2-pyridinyl)methyl)thio)-1H-Benzimidazole (Pantaprazole intermediate) 5-(Difluoromethoxy)-2-{[(3,4-dimethoxy-2-pyridinyl)-methyl]-thio}-1H-benzim 5-DIFLUOROMETHOXY-2-[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL] THIO-1H-BENZIMIDAZOLE =98% 5-DIFLUORMETHOXY-2[(3,4-DIMETHOXY-2-PRIDIXY)METHYLTHIO]-1H-BENZIMIDAZOLE 5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]thio}-1H-benzimidazole 5-Difluoromethoxy-2-(3,4-dimethoxy-pyridin-2-ylmethylsulfanyl)-1H-benzoimidazole 5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulphanyl}-1H-benzimidazole Pantoprazole Impurity 2(Pantoprazole EP Impurity B) 4-diMethoxy-2-pyridinyl)Methyl]thio-1H-benziMidazole 5-DifluoroMethoxy-2-[(3 Pantoprazole Sulphide Compound Pantoprazole EP IMpurity-B (USP RC B) 5-DIFLUOROMETHOXY-2-[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]THIO-1H-BENZIMIDAZOLE PANTOPRAZOLE SULFIDE Pantoprazole EP IMpurity B 5-DifluoroMethoxy-2-[(3,4-diMethoxy-2-pyridyl)Methyl]thio-1H-benziMidazole, 95% Pantoprazole Sulfide (Pantoprazole IMpurity B) 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridiny)-methyl]thio]-1H-benzimidazole 1H-BenziMidazole,6-(difluoroMethoxy)-2-[[(3,4-diMethoxy-2-pyridinyl)Methyl]thio]- Pantoprazole Sodium Hydrate Impurity pantoprazole sulphide Pantoprazole Related CoMpound Pantoprazole Sodium impurity 5-(Difluoromethoxy)-2- {[( 3,4 Dimethoxypyridin - 2- yl) methyl] thio}-1H-benzimidazolee 5-DIFLUOROMETHOXY-2-[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]THIO-1H-BENZIMIDAZOLE Pantoprazole Ep Imp B Pantoprazole-2 Pantoprazole EP Impurity B (Pantoprazole Sulfide) Pantoprazole sodium impurity B PantoprazoleSulfide> Pantoprazole Sulfur ether 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]thio]benzimidazole 5-(Difluoromethoxy)-2- [[(3,4-dimethoxy-2- pyridinyl)-2-methyl]thio]- 1H-benzimidazole 5-(Difluoromethoxy)-2-{[(3,4Dimethoxy pyridin-2- yl)methyl]thio}-1h-Benzimidazole(PantoSulphide) Pantoprazole EP Impurity B/ Pantoprazole Related Compound B (Pantoprazole Sulfide) Pantoprazole SulphideQ: What is Pantoprazole Sulphide Q: What is the CAS Number of Pantoprazole Sulphide Q: What is the storage condition of Pantoprazole Sulphide Q: What are the applications of Pantoprazole Sulphide Pantoprazole Related Compound B (5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H (1494910) PantoprazoleEPImpurityB-d6 5-Difluoromethoxy-2-H[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H- benzimidazole Pantoprazole Sodium Sesquihydrate Impurity B Pantoprazole Sodium EP Impurity B Pantoprazole USP Related Compound B 5-(Difluoro methoxy)-2-{[(3,4 dimethoxypyridin-2-yl)methyl]thio}-1H-benzimidazole (Panto Sulfide) 5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl)methyl]sulfanyl]-1H-benzimidazole 5-(Difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2- yl)methyl]thio}-1H-benzimidazole?(SULPHIIDE) 5-(Difluromethoxy)-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-Benzimidazole(pantoprazole sulfide) 5-Difluoromethoxy-2 {[(3,4-dimethyl-2-pyridyl) methyl] sulfur}-1H-benzimidazole Pantoprazole condensate Pantoprazole Sulfide, ≥ 98.0% Pantoprazole EP Impurity B Pantoprazole Related Compound B Pantoprazole sulfide in methanol Pantoprazole Sodium Sesquihydrate EP Impurity B