1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
![1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Structure](CAS/GIF/879132-48-6.gif)
- CAS No.
- 879132-48-6
- Chemical Name:
- 1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
- Synonyms
- 1-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;Atogepant Impurity 11;1-((2-(Trimethylsilyl);1-{[(2-TriMethylsilyl)eth...;-1H-pyrrolo[2,3-b]pyridin-2(3H);1-(2-trimethylsilylethoxymethyl)-3H-pyrrolo[2,3-b]pyridin-2-one;1-{[(2-TriMethylsilyl)ethoxy]Methyl}-1H-pyrrolo[2,3-b]pyridin-2-one;1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo?,3-b]pyridin-2(3H)-one;1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;1-{[2-(trimethylsilyl)ethoxy]methyl}-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one
- CBNumber:
- CB12553558
- Molecular Formula:
- C13H20N2O2Si
- Molecular Weight:
- 264.4
- MDL Number:
- MFCD17214392
- MOL File:
- 879132-48-6.mol
- MSDS File:
- SDS
| storage temp. | Sealed in dry,Room Temperature |
|---|---|
| Appearance | Light brown to orange Solid |
| CAS DataBase Reference | 879132-48-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 090604 | 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one | 879132-48-6 | 250.00mg | $742 | 2026-05-18 | Buy |
| Matrix Scientific | 090604 | 1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one | 879132-48-6 | 1.00g | $1647 | 2026-05-18 | Buy |
| Synthonix | T7635 | 1-{[(2-Trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-2-one 97.0% | 879132-48-6 | 1g | $64 | 2026-05-06 | Buy |
| Synthonix | T7635 | 1-{[(2-Trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-2-one 97.0% | 879132-48-6 | 5g | $80 | 2026-05-06 | Buy |
| Synthonix | T7635 | 1-{[(2-Trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridin-2-one 97.0% | 879132-48-6 | 10g | $150 | 2026-05-06 | Buy |
1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Chemical Properties, Uses, Production
Uses
1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one is used in the preparation of an inhibitor of respiratory syncytial virus.
Synthesis
![1,3-DIHYDRO-2H-PYRROLO[2,3-B]PYRIDINE-2-ONE](/CAS/GIF/5654-97-7.gif)
5654-97-7
76513-69-4
![1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one](/CAS/GIF/879132-48-6.gif)
879132-48-6
Under nitrogen protection, 7-aza-indol-2-one (2.00 g, 14.9 mmol) was dissolved in a solvent mixture of DMF (30 mL) and THF (30 mL) and cooled to 0 °C. Sodium hydride (0.600 g, 15.0 mmol) dispersed in 60% mineral oil was slowly added and kept stirring at 0 °C for 1 hour. Subsequently, 2-(trimethylsilyl)ethoxymethyl chloride (3.17 mL, 17.9 mmol) was added dropwise over 3 minutes, the ice bath was withdrawn, and the reaction mixture was allowed to warm up naturally to room temperature and stirring was continued for 21 hours. Upon completion of the reaction, the mixture was poured into water (50 mL) and ethyl acetate (50 mL) for partitioning. The aqueous phase was extracted with ethyl acetate (2 x 50 mL) and the organic phases were combined and washed sequentially with water (2 x 50 mL) and brine (50 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated, and purified by Biotage Horizon fast column chromatography (eluent: 25% ethyl acetate/hexane) to afford 1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (2.26 g) as a viscous, orange-colored oil.LC-MS analysis Conditions: retention time = 3.49 min; m/z = 265.20 [M+H]+ (column: Phenomenex C18 50×2.0 mm 3 μm; mobile phase A: 90% water:10% methanol:0.1% trifluoroacetic acid; mobile phase B: 10% water:90% methanol:0.1% trifluoroacetic acid; flow rate = 0.8 mL/min; gradient program: (starting B-phase ratio = 0%, final B-phase ratio = 100%, gradient time = 4 min, then held at 100% B-phase for 1 min; column temperature = 40 °C; detection wavelength = 220 nm).1H NMR (400 MHz, DMSO-d6) δ 8.15 (d, J=5.0 Hz, 1H), 7.65 (d, J=7.3 Hz, 1H), 7.05 ( dd, J=7.2,5.4 Hz, 1H), 5.07 (s, 2H), 3.69 (s, 2H), 3.59 (t, J=8.0 Hz, 2H), 0.85 (t, J=8.0 Hz, 2H), -0.06 (s, 9H).
References
[1] Patent: WO2016/172424, 2016, A1. Location in patent: Page/Page column 90; 91
1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai potentpharm CO.,Ltd | 13524892556 | sales-cn@potentpharm.com | China | 1011 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Syncozymes (Shanghai) Co.,Ltd. | 021-68187180 13681683526 | lchen@syncozymes.com | China | 412 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
879132-48-6 (1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one) Related Search:
1of2
