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spiro
spiro<benzofuran-3(2H),4'-piperidine Structure
spiro
CAS No.
171-77-7
Chemical Name:
spiro
Synonyms
spiro;2H-Spiro[benzofuran-3,4'-piperidine];spiro
CBNumber:
CB12561087
Molecular Formula:
C12H15NO
Molecular Weight:
189.25
MDL Number:
MFCD20488777
MOL File:
171-77-7.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:45
Product description Number Pack Size Price
2H-Spiro[benzofuran-3,4'-piperidine] 7755CV 100mg $181
2H-SPIRO[BENZOFURAN-3,4'-PIPERIDINE] 95.00% CHM0388246 5MG $504.88
2H-Spiro[benzofuran-3,4'-piperidine] 7755CV 1g $546
2H-Spiro[1-benzofuran-3,4'-piperidine] 97% 4H56-1-345 250mg $640
2H-Spiro[1-benzofuran-3,4'-piperidine] 97% 4H56-1-345 1g $1280
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spiro

Boiling point 320.4±42.0 °C(Predicted)
Density 1.14±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 10.60±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990

spiroMore Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific 7755CV 2H-Spiro[benzofuran-3,4'-piperidine] 171-77-7 100mg $181 2021-12-16 Buy
American Custom Chemicals Corporation CHM0388246 2H-SPIRO[BENZOFURAN-3,4'-PIPERIDINE] 95.00% 171-77-7 5MG $504.88 2021-12-16 Buy
AK Scientific 7755CV 2H-Spiro[benzofuran-3,4'-piperidine] 171-77-7 1g $546 2021-12-16 Buy
SynQuest Laboratories 4H56-1-345 2H-Spiro[1-benzofuran-3,4'-piperidine] 97% 171-77-7 250mg $640 2021-12-16 Buy
SynQuest Laboratories 4H56-1-345 2H-Spiro[1-benzofuran-3,4'-piperidine] 97% 171-77-7 1g $1280 2021-12-16 Buy
Product number Packaging Price Buy
7755CV 100mg $181 Buy
CHM0388246 5MG $504.88 Buy
7755CV 1g $546 Buy
4H56-1-345 250mg $640 Buy
4H56-1-345 1g $1280 Buy

spiro

Synthesis

1'-benzyl-spiro[benzofuran-3,4'-piperidine]

72374-35-7

spiro<benzofuran-3(2H),4'-piperidine

171-77-7

Preparation of Example 20: A suspension of 1-benzyl-spiro[benzofuran-3,4-piperidine] (1.0 g, 3.58 mmol) was formed with 10% palladium carbon (750 mg) in ethanol (30 mL). To this suspension was added spiro H-benzofuran-3,4'-piperidine ammonium formate (1.13 g, 17.94 mmol) in one go. The reaction mixture was heated to reflux for 1.25 hours. After completion of the reaction, the mixture was cooled, filtered through Arbocel and the filter cake was washed with additional ethanol. The filtrate was evaporated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using a gradient elution of dichloromethane: methanol: 0.88 ammonia (100:0:0 to 90:10:1) to give 2H-spiro[benzofuran-3,4'-piperidinium] as a cream-colored solid (489 mg, 72% yield). The product was confirmed by 1HNMR (CDCl3, 400MHz): δ 1.72 (m, 2H), 1.80-1.96 (m, 2H), 2.70 (m, 2H), 3.11 (m, 2H), 4.40 (s, 2H), 6.79 (m, 1H), 6.88 (m, 1H), 7.13 (m, 1H), 7.14 (m, 1H). LRMS (ES+): m/z 190 [MH]+.

References

[1] Patent: WO2006/92731, 2006, A1. Location in patent: Page/Page column 46

spiro

Raw materials

1'-benzyl-spiro[benzofuran-3,4'-piperidine] Ethanol Ammonium formate

Preparation Products

spiro

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Supplier Advantage
Career Henan Chemica Co 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Changzhou AniKare Pharmatech Co., Ltd. 		58
Qingdao Minzhi Yijie new material Co., LTD 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
skychemical Co.Ltd 57
Aloespharm Co., Ltd. 55
skychemical Co.Ltd 55

spiro[2H-1-benzofuran-3,4'-piperidine] spiro spiro 2H-SPIRO[1-BENZOFURAN-3,4'-PIPERIDINE spiro 2H-Spiro[benzofuran-3,4'-piperidine] 2H-Spiro[1-benzofuran-3,4'-piperidine] 171-77-7 171-77-9