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ChemicalBook >> CAS DataBase List >>2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Structure
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- structure
CAS No.
452339-73-0
Chemical Name:
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
Synonyms
(5R)-5-(2,2-DiMethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one;(R)-5-(2,2-DIMETHYL-4H-BENZO[D][1,3]DIOXIN-6-YL)OXAZOLIDIN-2-ONE;BNKY020-VT04;Vilanterol internate 1;Vilanterol Impurity 29;Vilanterol Impurity 74;(5R)-2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl);(5R)-2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-y...;(R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxazolidinone;(R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
CBNumber:
CB12563399
Molecular Formula:
C13H15NO4
Molecular Weight:
249.26
MDL Number:
MFCD21362968
MOL File:
452339-73-0.mol
MSDS File:
SDS
Last updated:2026-05-27 23:24:05
Request For Quotation

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Properties

Melting point 160 - 163°C
Boiling point 489.6±45.0 °C(Predicted)
Density 1.223±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Sparingly), Methanol (Slightly)
pka 12.29±0.40(Predicted)
form Solid
color White to Off-White
InChI InChI=1S/C13H15NO4/c1-13(2)16-7-9-5-8(3-4-10(9)18-13)11-6-14-12(15)17-11/h3-5,11H,6-7H2,1-2H3,(H,14,15)/t11-/m0/s1
InChIKey JUEBDVANOFZMMX-NSHDSACASA-N
SMILES O1[C@H](C2=CC=C3OC(C)(C)OCC3=C2)CNC1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-D456836-50MG (R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one 452339-73-0 50mg $217 2026-06-03 Buy
TRC TRC-D456836-10MG (R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one 452339-73-0 10mg $64 2026-06-03 Buy
TRC TRC-D456836-100MG (R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one 452339-73-0 100mg $346 2026-06-03 Buy
Matrix Scientific 300285 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 452339-73-0 250.00mg $41 2026-05-19 Buy
Matrix Scientific 300285 (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one 452339-73-0 1.00g $110 2026-05-19 Buy
Product number Packaging Price Buy
TRC-D456836-50MG 50mg $217 Buy
TRC-D456836-10MG 10mg $64 Buy
TRC-D456836-100MG 100mg $346 Buy
300285 250.00mg $41 Buy
300285 1.00g $110 Buy

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Chemical Properties, Uses, Production

Uses

(5R)-5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-Oxazolidinone (2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-) is a reagent applied in the preparation of alkyl-linked di-phenyl aminoalcohols as long-acting β2 adrenergic receptor agonist. It is used as an antedrug.

Synthesis

(R)-2-amino-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-ol (29.8g, 134.0mmol, 1.0eq.) and tetrahydrofuran (300mL) were added to the reaction flask under nitrogen protection, the reaction solution was heated to 40-60°C, and N, N'- Carbonyldiimidazole (22.7 g, 140.0 mmol, 1.05 eq.).After the addition, the reaction solution was kept at a temperature of 40-60° C. and stirred until the raw material reaction was completed. After the reaction, the solution was cooled to 15-30° C., and water (400 mL) was added. Then, the mixture was continuously cooled to 0-10°C and kept stirring. The precipitated solid was filtered, and the filter cake was washed with water. The filter cake was collected and dried under reduced pressure to obtain 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- (30 g, 120.4 mmol, 89.9% yield).
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-

References

[1] Patent: CN106957313, 2017, A. Location in patent: Paragraph 0014-0015
[2] Organic and biomolecular chemistry, 2003, vol. 1, # 7, p. 1106 - 1111
[3] Patent: US2015/239862, 2015, A1. Location in patent: Paragraph 0133; 0134
[4] Patent: WO2004/22547, 2004, A1. Location in patent: Page 43-44
[5] Patent: WO2004/37773, 2004, A1. Location in patent: Page 46

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- synthesis

452339-72-9
452339-73-0
Synthesis of 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- from CarbaMic acid, [(2R)-2-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Preparation Products And Raw materials

Raw materials

(R)-2-Amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol CarbaMic acid, [(2R)-2-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester 1,1'-Carbonyldiimidazole Ethyl acetate

Preparation Products

2-Oxazolidinone, 3-[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]-5-(2,2-diMethyl-4H-1, 3-benzodioxin-6-yl)-, (5R)- Vilanterol Trifenatate

2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Suppliers

Global Suppliers ( 151)
Supplier Tel Email Country ProdList Advantage
Shanghai Goyic Pharmaceutical & Chemical Co., Ltd. 021-50689757 15618953996 sales@goyic.com China 310 58
Anhui Dexinjia Biopharm Co., Ltd 0531-82375893 15553111391 phoebe@jndxj.com China 285 58
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7909 65
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Shanghai Fuhe Chemistry Technology Co., Ltd. 0086-21-67651709 cfx759@hotmail.com China 409 57
Shenzhen HwaGen Pharmaceutical Co.,Ltd Q:3003761227 17722620669 liangcong.yi@rafflespt.com China 274 58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 21-33585366 13311639313 sales@shyrchem.com China 807 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Shijiazhuang Lickon PharmaTech Co., Ltd. 031185291771 13832391721 yaofeng2005@163.com China 947 58
Jiaxing Novartis Chemical Co., Ltd. 18957373295 China 1579 58
Supplier Advantage
Shanghai Goyic Pharmaceutical & Chemical Co., Ltd. 58
Anhui Dexinjia Biopharm Co., Ltd 58
Daicel Chiral Technologies (China)CO.,LTD 65
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Shanghai Fuhe Chemistry Technology Co., Ltd. 57
Shenzhen HwaGen Pharmaceutical Co.,Ltd 58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 55
Haoyuan Chemexpress Co., Ltd. 61
Shijiazhuang Lickon PharmaTech Co., Ltd. 58
Jiaxing Novartis Chemical Co., Ltd. 58

View Latest Price from 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- pictures 2026-03-20 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-
452339-73-0
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
(5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-on e pictures 2025-06-20 (5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-on e
452339-73-0
 1kg 0.99 100tons Hebei Yanxi Chemical Co., Ltd.
(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one pictures 2025-04-04 (5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one
452339-73-0
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

452339-73-0 (2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-) Related Search:

2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone Ethanol, 2-[(2,6-dichlorophenyl)Methoxy]- Benzene, 2-[[2-[(6-broMohexyl)oxy]ethoxy]Methyl]-1,3-dichloro 21ξ-morpholino-23,24-dinor-chola-4,20-dien-3-one Androstenone hydrazone
17-Iodoandrosta-5,16-dien-3beta-ol Bisnorcholenaldehyde tert-Butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate CarbaMic acid, [(2R)-2-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]-, 1,1-diMethylethyl ester N-(1-Cyclohexen-1-yl)morpholine
Abiraterone

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2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- (5R)-2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl) (5R)-5-(2,2-DiMethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one (R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one BNKY020-VT04 Vilanterol Impurity 29 Vilanterol internate 1 (5R)-2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-y... TIANFU CHEM 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- (R)-5-(2,2-demethyl-4H-benzo[d] [1,3] dioxin -6-yl)oxazolidin-2-one Vilanterol Impurity 74 (5R) -5- (2,2-dimethyl-4H-1,3-benzodioxane-6-yl) -1,3-oxazolidine-2-one (R)-5-(2,2-Dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxazolidinone 5R-(5R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one (R)-5-(2,2-DIMETHYL-4H-BENZO[D][1,3]DIOXIN-6-YL)OXAZOLIDIN-2-ONE 452339-73-0 Intermediate 452339-73-0