ChemicalBook >> CAS DataBase List >>2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI)

2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI)

2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) structure

CAS No.: 166095-95-0

Chemical Name:: 2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI)

Synonyms: BMS-191095 hydrochloride;BMS-191095 hydrochloride >=98% (HPLC);(3R,4S)-4-(((1H-imidazol-2-yl)methyl)(4-chlorophenyl)amino)-3-hydroxy-2,2-dimethylchromane-6-carbonitrile hydrochloride;(3R,4S)-4-[4-chloro-N-(1H-imidazol-2-ylmethyl)anilino]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrile:hydrochloride;2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI)

CBNumber:: CB12626322

Molecular Formula:: C22H22Cl2N4O2

Molecular Weight:: 445.34168

MDL Number:: MFCD00953840

MOL File:: 166095-95-0.mol

TDS File:: TDS

Last updated:2026-05-27 23:26:44

Request For Quotation

2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) Properties

storage temp.	room temp
solubility	DMSO: 20mg/mL, clear
form	powder
color	white to beige
InChIKey	TZLMTXNZECPICU-JUDYQFGCSA-N
SMILES	CC1(C)OC2=CC=C(C#N)C=C2[C@H](N(CC3=NC=CN3)C4=CC=C(Cl)C=C4)[C@H]1O.[H]Cl
FDA UNII	3I2CFR0UVU
UNSPSC Code	12352202
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs	Respiratory system
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	HCH0316418	(3R,4S)-4-[(4-CHLOROPHENYL)-(1H-IMIDAZOL-2-YLMETHYL)AMINO]-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-6-CARBONITRILE MONOHYDROCHLORIDE 95.00%	166095-95-0	5MG	$499.8	2021-12-16	Buy

Product number	Packaging	Price	Buy
HCH0316418	5MG	$499.8	Buy

2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) Chemical Properties, Uses, Production

Uses

BMS-191095 hydrochloride is a mitochondrial KATP channel opener. BMS-191095 hydrochloride can protect the myocardium without causing vasodilation or affecting electrophysiology, by prolonging the contraction time during ischemia, improving contractile function after reperfusion, and reducing lactate dehydrogenase (LDHM) release, thereby exerting its cardioprotective effects[1].

Biological Activity

BMS-191095 is a potent and selective mitochondrial ATP-sensitive K1 channel (KATP) channel opener devoid of peripheral vasodilating activity. BMS-191095 improves postischemic recovery of function and reduced lactate dehydrogenase release in the isolated r at hearts.

References

[1] Grover GJ, et al. Pharmacologic profile of the selective mitochondrial-K(ATP) opener BMS-191095 for treatment of acute myocardial ischemia. Cardiovasc Drug Rev. 2002 Summer;20(2):121-36. DOI:10.1111/j.1527-3466.2002.tb00187.x

2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) Suppliers

Global Suppliers ( 5)

Supplier	Tel	Email	Country	ProdList	Advantage
Energy Chemical	400-0056266	marketing1@energy-chemical.com	China	44927	58
Suzhou Meishi Biotechnology Co., Ltd.	1173954148q	meishipharma@126.com	China	20027	58
TargetMol	400-821-0310 15002144251	xuexiang.shao@tsbiochem.com	China	29128	58
Shandong Ziyi Pharmaceutical Co., Ltd.	17860786593	1181917242@qq.com	China	10000	58

Supplier	Advantage
Energy Chemical	58
Suzhou Meishi Biotechnology Co., Ltd.	58
TargetMol	58
Shandong Ziyi Pharmaceutical Co., Ltd.	58

166095-95-0 (2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI)) Related Search:

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2H-1-Benzopyran-6-carbonitrile, 4-[(4-chlorophenyl)(1H-iMidazol-2-ylMethyl)aMino]-3,4-dihydro-3-hydroxy-2,2-diMethyl-, Monohydrochloride, (3R,4S)- (9CI) (3R,4S)-4-[4-chloro-N-(1H-imidazol-2-ylmethyl)anilino]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carbonitrile:hydrochloride BMS-191095 hydrochloride >=98% (HPLC) BMS-191095 hydrochloride (3R,4S)-4-(((1H-imidazol-2-yl)methyl)(4-chlorophenyl)amino)-3-hydroxy-2,2-dimethylchromane-6-carbonitrile hydrochloride 166095-95-0