2-Chloro-1H-imidazole
- CAS No.
- 16265-04-6
- Chemical Name:
- 2-Chloro-1H-imidazole
- Synonyms
- oroimidazoL;2-CHLORO-1H-IMIDAZOLE;1H-Imidazole,2-chloro-;2-Chloro-1H-imidazole >2-Chloro-1H-imidazole 97%;2-Chloro-1H-imidazole
- CBNumber:
- CB1263569
- Molecular Formula:
- C3H3ClN2
- Molecular Weight:
- 102.52
- MDL Number:
- MFCD02179530
- MOL File:
- 16265-04-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 165-170 °C |
|---|---|
| Boiling point | 252.7±23.0 °C(Predicted) |
| Density | 1.405±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 11.23±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| InChI | InChI=1S/C3H3ClN2/c4-3-5-1-2-6-3/h1-2H,(H,5,6) |
| InChIKey | OCVXSFKKWXMYPF-UHFFFAOYSA-N |
| SMILES | C1(Cl)NC=CN=1 |
| CAS DataBase Reference | 16265-04-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-36/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2933299090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
2-Chloro-1H-imidazole price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 666408 | 2-Chloro-1H-imidazole 97% | 16265-04-6 | 250mg | $113 | 2026-04-30 | Buy |
| Sigma-Aldrich | 666408 | 2-Chloro-1H-imidazole 97% | 16265-04-6 | 1g | $236 | 2026-04-30 | Buy |
| TCI Chemical | C2685 | 2-Chloro-1H-imidazole >98.0%(GC) | 16265-04-6 | 200mg | $73 | 2021-12-16 | Buy |
| TCI Chemical | C2685 | 2-Chloro-1H-imidazole >98.0%(GC) | 16265-04-6 | 1g | $307 | 2026-04-30 | Buy |
| Apolloscientific | OR10411 | 2-Chloro-1H-imidazole >98% | 16265-04-6 | 250mg | $21 | 2026-06-04 | Buy |
2-Chloro-1H-imidazole Chemical Properties, Uses, Production
Chemical Properties
2-Chloro-1H-imidazole is an imidazole compound with the appearance of white to off-white powder to crystal, molecular weight 102.52, melting point 166.0 ~ 170.0 °C, it is sensitive to heat, and is usually stored at 2-8°C. It can be used as an antimicrobial agent in the manufacture of imidazoles.
Uses
2-Chloro-1H-imidazole can be used as an organic reaction reagent for the study of halogenated imidazoles. It is mainly used for chemical and laboratory research use.
Uses
2-Chloroimidazole is used in pharmaceuticals, drug candidates, ligands for transition metal catalysts and other molecular functional materials.
Definition
ChEBI: An imidazole compound having a chloro substituent at the 2-position.
Synthesis Reference(s)
The Journal of Organic Chemistry, 63, p. 12, 1998 DOI: 10.1021/jo970355+
Synthesis
61278-81-7
16265-04-6
The general procedure for the synthesis of 2-chloroimidazole from 1-(diethoxymethyl)imidazole is as follows: with reference to Example 9, 2-chloroimidazole was prepared as follows: N-(diethoxymethyl)imidazole (50.0 g) was dissolved in tetrahydrofuran (200 ml), and a n-hexane solution of 2.6 M n-butyllithium (120 ml) was added slowly and dropwise to this solution. The addition of tetrahydrofuran solution (100 ml) of hexachloroethane (73.9 g) was continued dropwise at -35°C. The reaction mixture was kept at the same temperature for 5 min, then warmed up to -20°C and 6N hydrochloric acid (100 ml) was added, after which it was restored to room temperature and left to stand for 5 min. The aqueous layer was separated and the organic layer was extracted with 1N hydrochloric acid, the extract was combined with the aqueous layer and washed with ether. This was followed by neutralization with 6N aqueous sodium hydroxide and extraction with ethyl acetate. The organic layer was separated, dried with anhydrous magnesium sulfate and the solvent was removed by distillation to give the crude product. The crude product was ground with dichloromethane to give finally 2-chloroimidazole (26.0 g, yield: 85.0%) as a light brown solid.1H-NMR (CDCl3) δ (ppm): 10.64 (1H, bs), 7.05 (1H, s).
References
[1] Patent: EP1553088, 2005, A1. Location in patent: Page/Page column 52
2-Chloro-1H-imidazole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80534353 19917294565 | et@chemextension.com | China | 3904 | 55 |
| Changzhou Kechem Bio-Scientific Co., LTD. | 0519-68985668 13685222090 | sales@kechem.cn | China | 26012 | 58 |
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 968 | 68 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 2-Chloro-1H-imidazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-04-11 | 2-Chloro-1H-imidazole
16265-04-6
|
$100.00 | 25g | 99% | 1000g | Shijiazhuang Gantuo Biotechnology Co., Ltd | |
 |
2021-08-12 | 2-Chloro-1H-imidazole
16265-04-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 2-Chloro-1H-imidazole
16265-04-6
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2-Chloro-1H-imidazole
16265-04-6
- $100.00
- 99%
- Shijiazhuang Gantuo Biotechnology Co., Ltd
-
- 2-Chloro-1H-imidazole
16265-04-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Chloro-1H-imidazole
16265-04-6
- $1.00
- 99%
- Career Henan Chemical Co
