1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester
- CAS No.
- 942190-61-6
- Chemical Name:
- 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester
- Synonyms
- Methyl 1-Boc-3-hydroxypyrrolidine-3-carboxylate;1-Boc-3-hydroxypyrrolidine-3-carboxylic acid methyl ester;Methyl 1-Boc-3-hydroxypyrrolidine-3-carboxylate - [M12685];1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester;1-tert-Butyl 3-Methyl 3-hydroxypyrrolidine-1,3-dicarboxylate;1-O-tert-butyl 3-O-methyl 3-hydroxypyrrolidine-1,3-dicarboxylate;1,3-Pyrrolidinedicarboxylic acid,3-hydroxy-,1-(1,1-dimethylethyl) 3-methyl ester
- CBNumber:
- CB12644430
- Molecular Formula:
- C11H19NO5
- Molecular Weight:
- 245.27
- MDL Number:
- MFCD12400943
- MOL File:
- 942190-61-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-tert-Butyl3-methyl3-hydroxypyrrolidine-1,3-dicarboxylate | CS-W000700 | 100mg | $86 |
| 1-tert-Butyl3-methyl3-hydroxypyrrolidine-1,3-dicarboxylate | 1954AQ | 500mg | $414.8 |
| Methyl1-Boc-3-hydroxypyrrolidine-3-carboxylate 95+% | 123056 | 1g | $498 |
| 1-TERT-BUTYL-3-METHYL-3-HYDROXYPYRROLIDINE-1,3-DICARBOXYLATE 95.00% | CHM0238237 | 5MG | $499.4 |
| Methyl1-Boc-3-hydroxypyrrolidine-3-carboxylate 95+% | M12685 | 10g | $1520 |
| More product size | |||
| Melting point | 71 - 73°C |
|---|---|
| Boiling point | 314.5±42.0 °C(Predicted) |
| Density | 1.226±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 12.57±0.20(Predicted) |
| color | Off-White to Pale Brown |
| InChI | InChI=1S/C11H19NO5/c1-10(2,3)17-9(14)12-6-5-11(15,7-12)8(13)16-4/h15H,5-7H2,1-4H3 |
| InChIKey | ALAIMDFVDAWVMO-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(O)(C(OC)=O)C1 |
| CAS DataBase Reference | 942190-61-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335-H412 |
| Precautionary statements | P261-P273-P305+P351+P338 |
1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-W000700 | 1-tert-Butyl3-methyl3-hydroxypyrrolidine-1,3-dicarboxylate | 942190-61-6 | 100mg | $86 | 2021-12-16 | Buy |
| AK Scientific | 1954AQ | 1-tert-Butyl3-methyl3-hydroxypyrrolidine-1,3-dicarboxylate | 942190-61-6 | 500mg | $414.8 | 2021-12-16 | Buy |
| Matrix Scientific | 123056 | Methyl1-Boc-3-hydroxypyrrolidine-3-carboxylate 95+% | 942190-61-6 | 1g | $498 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0238237 | 1-TERT-BUTYL-3-METHYL-3-HYDROXYPYRROLIDINE-1,3-DICARBOXYLATE 95.00% | 942190-61-6 | 5MG | $499.4 | 2021-12-16 | Buy |
| Synthonix | M12685 | Methyl1-Boc-3-hydroxypyrrolidine-3-carboxylate 95+% | 942190-61-6 | 10g | $1520 | 2021-12-16 | Buy |
1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester Chemical Properties,Uses,Production
Uses
1-tert-Butyl-3-Methyl 3-Hydroxypyrrolidine-1,3-Dicarboxylate can be used as LRRK2 inhibitors to treat diseases in which LRRK2 kinase is involved.
Synthesis
67-56-1
24424-99-5
942190-61-6
A mixture of compound 2W (5.3 g, 25 mmol), methanol (50 ml) and dioxane solution of 4N HCl (10 ml) was placed in a sealed tube and the reaction was heated at 70°C overnight. Upon completion of the reaction, the reaction mixture was concentrated, followed by addition of tetrahydrofuran (20 ml), dichloromethane (50 ml), triethylamine (16 ml) and di-tert-butyl dicarbonate (11 g). The mixture was stirred at room temperature overnight and then concentrated. The concentrated residue was diluted with ether (200 ml) and washed with deionized water (100 ml). The organic layer was separated, dried with anhydrous sodium sulfate, filtered and concentrated again. Finally, the residue was purified by silica gel column chromatography using 1:1 (v/v) ethyl acetate/hexanes and 2:1 (v/v) ethyl acetate/hexanes sequentially as eluent to give the target product 3W (4.35 g, 71% yield).
References
[1] Patent: WO2007/70398, 2007, A1. Location in patent: Page/Page column 440
1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +8618118463618 | sales1@artkmedchem.com | China | 39020 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39927 | 58 |
View Lastest Price from 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester
942190-61-6
|
US $280.00 / G | 1G | 99% | customise | Career Henan Chemical Co |
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- 1-Boc-3-hydroxy-3-pyrrolidinedicarboxylic acid Methyl ester
942190-61-6
- US $280.00 / G
- 99%
- Career Henan Chemical Co
