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ChemicalBook >> CAS DataBase List >>Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester Structure
Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester structure
CAS No.
1246213-45-5
Chemical Name:
Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester
Synonyms
Ivacaftor Methylcarbonate;N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide;2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate;N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide - [M72506];Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester
CBNumber:
CB12657777
Molecular Formula:
C26H30N2O5
Molecular Weight:
450.53
MDL Number:
MFCD22665917
MOL File:
1246213-45-5.mol
MSDS File:
SDS
Last updated:2023-05-16 08:28:57
Product description Number Pack Size Price
N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 457826 1mg $326
N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 457826 2.5mg $489
N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 98% M72506 100mg $210
N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 98% M72506 250mg $340
N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 98% M72506 1g $800
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Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester Properties

Boiling point 583℃
Density 1.198
Flash point 306℃
solubility Acetone, Dichloromethane, Methanol
form Solid
pka 11.60±0.70(Predicted)
color Foamy

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 457826 N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 1246213-45-5 1mg $326 2026-06-03 Buy
Usbiological 457826 N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 1246213-45-5 2.5mg $489 2026-06-03 Buy
Synthonix M72506 N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 98% 1246213-45-5 100mg $210 2026-05-06 Buy
Synthonix M72506 N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 98% 1246213-45-5 250mg $340 2026-05-06 Buy
Synthonix M72506 N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide 98% 1246213-45-5 1g $800 2026-05-06 Buy
Product number Packaging Price Buy
457826 1mg $326 Buy
457826 2.5mg $489 Buy
M72506 100mg $210 Buy
M72506 250mg $340 Buy
M72506 1g $800 Buy

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester Chemical Properties,Uses,Production

Uses

N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide is an intermediate in the synthesis of Ivacaftor (4-tertbutyl-d9) (Major) (I940603). Ivacaftor (4-tertbutyl-d9) (Major) is isotopically labelled form of Ivacaftor (I940600), which is used in the treatment of cystic fibrosis.

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester synthesis

1182822-31-6
13721-01-2
1246213-45-5
Synthesis of Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester from 5-amino-2,4-di-tert-butylphenyl methyl carbonate and 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester Preparation Products And Raw materials

Raw materials

5-amino-2,4-di-tert-butylphenyl methyl carbonate 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID

Preparation Products

Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd. 		+86-18032440182 +86-18032440182 sales01@dingminpharma.com China 305 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai YuLue Chemical Co., Ltd. 021-60345187 13671753212 lzz841106@aliyun.com China 10244 55
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1371 58
Shanghai Moss Medicine Technology Co., Ltd. +86-188369842 +86-15618151133 188369842@qq.com China 1965 58
Jinan Ruisi Pharmaceutical Technology Co., LTD 0531-0531-69900633 19963472814 changyuan20@163.com China 5562 58
Shanghai Haohong Scientific Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 39651 58
SHAANXI DIDEU MEDICHEM CO.LTD 029-029-81123119 17391733320 1021@dideu.com China 9389 58
Supplier Advantage
HANGZHOU LEAP CHEM CO., LTD. 		58
Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd. 		58
BOC Sciences 65
Shanghai YuLue Chemical Co., Ltd. 55
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58
Shanghai Moss Medicine Technology Co., Ltd. 58
Jinan Ruisi Pharmaceutical Technology Co., LTD 58
Shanghai Haohong Scientific Co., Ltd. 58
SHAANXI DIDEU MEDICHEM CO.LTD 58

1246213-45-5(Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester)Related Search:

Methyl 3-(3-carbaMoyl-4-(3-MethoxyphenylaMino)-8-Methylquinolin-6-ylthio)benzoate 4-HYDROXY-1-METHYL-2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID (3-METHOXY-PHENYL)-AMIDE N-[2-(TERT-BUTYL)PHENYL]-6-HYDROXY-4-OXO-1,2-DIHYDRO-4H-PYRROLO[3,2,1-IJ]QUINOLINE-5-CARBOXAMIDE 3-Quinolinecarboxamide, 1,4-dihydro-1,2-dimethyl-4-oxo-N-phenyl- 3-Quinolinecarboxylic acid, 4-amino-6-[(4-methoxybenzoyl)amino]-, ethyl ester
N-(3-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide

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Carbonic acid 5-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-2,4-bis(1,1-dimethylethyl)phenyl methyl ester 2,4-di-tert-butyl-5-(4-oxo-1,4-dihydroquinoline-3-carboxamido)phenyl methyl carbonate N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide Ivacaftor Methylcarbonate N-[5-(Methoxycarbonyloxy)-2,4-di(tert-butyl)phenyl]-4-oxo-1H-quinoline-3-carboxamide - [M72506] 1246213-45-5