Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate
![Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate Structure](CAS/20150408/GIF/174799-52-1.gif)
- CAS No.
- 174799-52-1
- Chemical Name:
- Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate
- Synonyms
- SKL541;tert-Butyl (2-(benzylamino);N-Benzyl-N'-Boc-ethylenediamine;N2-Boc-N1-benzyl-1,2-ethylenediamine;Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate;Nα-benzyl-Nω-tert-butoxycarbonylethylene diamine;(2-(benzylamino)ethyl)aminomacetic acidtertbutyl ester;Carbamic acid, N-[2-[(phenylmethyl)amino]ethyl]-, 1,1-dimethylethyl ester
- CBNumber:
- CB12722338
- Molecular Formula:
- C14H22N2O2
- Molecular Weight:
- 250.34
- MDL Number:
- MFCD04114275
- MOL File:
- 174799-52-1.mol
- MSDS File:
- SDS
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
|---|---|
| Appearance | Colorless to light yellow Viscous Liquid |
| InChI | InChI=1S/C14H22N2O2/c1-14(2,3)18-13(17)16-10-9-15-11-12-7-5-4-6-8-12/h4-8,15H,9-11H2,1-3H3,(H,16,17) |
| InChIKey | ZSJCBAQDXIZTTC-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NCCNCC1=CC=CC=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H318-H315-H335-H302 |
| Precautionary statements | P280-P305+P351+P338-P310-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362 |
Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | ZGA79952 | N-Benzyl-N'-boc-ethylenediamine | 174799-52-1 | 10g | $354 | 2026-06-05 | Buy |
| Activate Scientific | AS74574 | N-Benzyl-N'-boc-ethylenediamine 95% | 174799-52-1 | 1g | $113 | 2026-06-04 | Buy |
| Activate Scientific | AS74574 | N-Benzyl-N'-boc-ethylenediamine 95% | 174799-52-1 | 5g | $465 | 2026-06-04 | Buy |
| Synthonix | B57945 | tert-Butyl (2-(benzylamino)ethyl)carbamate 95+% | 174799-52-1 | 100mg | $19 | 2026-05-06 | Buy |
| Synthonix | B57945 | tert-Butyl (2-(benzylamino)ethyl)carbamate 95+% | 174799-52-1 | 250mg | $23 | 2026-05-06 | Buy |
Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate Chemical Properties, Uses, Production
Uses
tert-Butyl (2-(Benzylamino)ethyl)carbamate is used in preparation of AGC kinase inhibitor and application.
Synthesis
57260-73-8
100-52-7
![Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate](/CAS/20150408/GIF/174799-52-1.gif)
174799-52-1
The general procedure for the synthesis of tert-butyl (2-(benzylamino)ethyl)carbamate from N-tert-butoxycarbonyl-1,2-ethylenediamine and benzaldehyde is as follows: 1. benzaldehyde (4.7 g, 44.0 mmol) was added to a methanol (60 mL) solution of N-Boc-1,2-ethylenediamine (6.4 g, 40.0 mmol). 2. The reaction mixture was stirred at room temperature overnight. 3. The reaction mixture was cooled to -10 °C (using an ice/salt bath) and NaBH4 (9.1 g, 240.0 mmol) was added in batches over 30 minutes. 4. After the addition was complete, the ice bath was removed and the reaction mixture was continued to be stirred at room temperature for 16 hours. 5. The solvent was evaporated and the residue was dissolved in EtOAc (150 mL) and poured into water (100 mL). 6. The organic layer was extracted with 0.5N HCl (3 x 100 mL). 7. The combined aqueous phases were cooled to 0°C and alkalized with saturated NaHCO3 solution. 8. The alkalized aqueous phase was extracted with CHCl3 (3 x 100 mL). 9. Combine the organic layers and wash with brine (200 mL). 10. Dry the organic layer with MgSO4, filter and evaporate the solvent in vacuum to obtain the target product tert-butyl (2-(benzylamino)ethyl)carbamate (9.2 g, 36.8 mmol, 92% yield) as a colorless oil. Product Characterization: - LC-MS [M + H]+: 251.2 (C14H22N2O2 + H, calculated value: 251.3). - TLC Rf (DCM/MeOH 9:1): 0.30.
References
[1] Patent: US2011/262355, 2011, A1. Location in patent: Page/Page column 135
[2] Patent: WO2011/133149, 2011, A1. Location in patent: Page/Page column 297-298
[3] Patent: WO2011/133150, 2011, A1. Location in patent: Page/Page column 299-300
[4] Patent: JP2016/41698, 2016, A. Location in patent: Paragraph 0364; 0375
[5] Chemical Communications, 2016, vol. 52, # 63, p. 9837 - 9840
Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate Preparation Products And Raw materials
Raw materials
Preparation Products
Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai yuanzuo medical technology co., LTD | 021-31775309; 15221510662 | yi_shiyan@yuanzuopharm.com | China | 139 | 58 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Thunder Biological Technology Co., Ltd. | 18621609968 | 1162686636@qq.com | China | 1034 | 58 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai Chainpharm Bio-medical Technology Co., Ltd. | +86-021-61727342 13611721451 | sales@chainpharm.com | China | 984 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| NovoChemy Ltd. | 86-(0)21-31261262 373522135 | sales@novochemy.com | China | 6491 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7964 | 55 |
View Latest Price from Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate manufacturers
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2026-03-11 | Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate
174799-52-1
|
1kg | 97% | 1000kg | Henan Aochuang Chemical Co.,Ltd. |
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- Tert-butyl N-[2-(benzylaMino)ethyl]carbaMate
174799-52-1
- 97%
- Henan Aochuang Chemical Co.,Ltd.
