NK314
- CAS No.
- 208237-49-4
- Chemical Name:
- NK314
- Synonyms
- NK314;NK-314; NK 314;FXBDAIVJLCTTAW-UHFFFAOYSA-N
- CBNumber:
- CB12731107
- Molecular Formula:
- C22H18ClNO4
- Molecular Weight:
- 395.84
- MDL Number:
- MFCD13152393
- MOL File:
- 208237-49-4.mol
- MSDS File:
- SDS
| FDA UNII | BH68FXM7X8 |
|---|
NK314 Chemical Properties, Uses, Production
Uses
NK 314 is an inhibitor for topoisomerase IIα, which generates the break of DNA double-strand. NK 314 arrests the cell cycle at G2 phase in human acute myeloid leukemia cells, inhibits the proliferation of CEM with IC90 of 55 nM[1].
IC 50
topoisomerase II alpha
References
[1] Guo L, et al., Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials. Mol Cancer Ther. 2007 May;6(5):1501-8. DOI:10.1158/1535-7163.MCT-06-0780
NK314 Preparation Products And Raw materials
Raw materials
Preparation Products
NK314 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
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