6-AMino-2-chloronicotinonitrile
- CAS No.
- 53554-20-4
- Chemical Name:
- 6-AMino-2-chloronicotinonitrile
- Synonyms
- 6-AMino-2-chloronicotinonitrile;6-Amino-2-chloro-3-pyridinecarbonitrile;6-amino-2-chloropyridine-3-carbonitrile;3-Pyridinecarbonitrile, 6-amino-2-chloro-
- CBNumber:
- CB12734113
- Molecular Formula:
- C6H4ClN3
- Molecular Weight:
- 153.57
- MDL Number:
- MFCD18802573
- MOL File:
- 53554-20-4.mol
| Product description | Number | Pack Size | Price |
| 6-Amino-2-chloronicotinonitrile | 3411DA | 250mg | $477 |
| 6-amino-2-chloronicotinonitrile 95% | CM177457 | 1g | $636 |
| 6-Amino-2-chloronicotinonitrile 95+% | CD11109196 | 1g | $673 |
| 6-Amino-2-chloronicotinonitrile 95% | A167074 | 1g | $782 |
| 6-Amino-2-chloronicotinonitrile | 53554204 | 1g | $919 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
6-AMino-2-chloronicotinonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 3411DA | 6-Amino-2-chloronicotinonitrile | 53554-20-4 | 250mg | $477 | 2021-12-16 | Buy |
| Chemenu | CM177457 | 6-amino-2-chloronicotinonitrile 95% | 53554-20-4 | 1g | $636 | 2021-12-16 | Buy |
| Crysdot | CD11109196 | 6-Amino-2-chloronicotinonitrile 95+% | 53554-20-4 | 1g | $673 | 2021-12-16 | Buy |
| Ambeed | A167074 | 6-Amino-2-chloronicotinonitrile 95% | 53554-20-4 | 1g | $782 | 2021-12-16 | Buy |
| Alichem | 53554204 | 6-Amino-2-chloronicotinonitrile | 53554-20-4 | 1g | $919 | 2021-12-16 | Buy |
6-AMino-2-chloronicotinonitrile Chemical Properties,Uses,Production
Synthesis
557-21-1
1221398-11-3
53554-20-4
6-Chloro-5-iodopyridin-2-amine (4.00 g, 15.7 mmol) and zinc cyanide (0.997 g, 8.50 mmol) were dissolved in 15 mL of N,N-dimethylformamide under argon protection. Subsequently, zinc cyanide was added, and the mixture was vigorously stirred and purged with a stream of argon for 5 min. Next, tris(dibenzylideneacetone)dipalladium(0) (0.642 g, 0.701 mmol) and 1,1'-bis(diphenylphosphino)ferrocene (0.784 g, 1.42 mmol) were added, and the reaction mixture was stirred for 10 min at 120 °C. After completion of the reaction, it was extracted with ethyl acetate and aqueous half-saturated sodium bicarbonate, and the organic phase was concentrated by filtration through silica gel. Finally, purification by silica gel column chromatography (elution gradient: cyclohexane/ethyl acetate 100/0→50/50) afforded the target product 6-amino-2-chlorocyanopyridine in a yield of 1.60 g and 66%. Mass spectrum (ESI+): m/z = 154 [M + H]+.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 5, p. 1697 - 1700
[2] Patent: US2018/37594, 2018, A1. Location in patent: Paragraph 0344-0347
[3] European Journal of Medicinal Chemistry, 2014, vol. 84, p. 404 - 416
6-AMino-2-chloronicotinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
6-AMino-2-chloronicotinonitrile Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Shanxi Tihondan Pharmaceutical Technology Co., Ltd | +8618235132063 | sales@tihondan.com | China | 3767 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
