6-Chloro-5-iodopyridin-2-aMine
- CAS No.
- 1221398-11-3
- Chemical Name:
- 6-Chloro-5-iodopyridin-2-aMine
- Synonyms
- 6-Chloro-5-iodopy;6-CHLORO-5-IODOPYRIDIN-2-AMIN;6-Chloro-5-iodopyridin-2-aMine;2-Amino-6-chloro-5-iodopyridine;6-chloro-5-iodo-2-aminopyridine;2-Pyridinamine, 6-chloro-5-iodo-;6-Chloro-5-iodo-pyridin-2-ylaMine;1221398-11-3 6-Chloro-5-iodopyridin-2-amine
- CBNumber:
- CB62666167
- Molecular Formula:
- C5H4ClIN2
- Molecular Weight:
- 254.46
- MDL Number:
- MFCD20486991
- MOL File:
- 1221398-11-3.mol
- MSDS File:
- SDS
6-Chloro-5-iodopyridin-2-aMine price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | WYB39811 | 6-Chloro-5-iodopyridin-2-amine | 1221398-11-3 | 5g | $472 | 2026-06-05 | Buy |
| Activate Scientific | AS110178 | 6-Chloro-5-iodopyridin-2-amine 97% | 1221398-11-3 | 1g | $43 | 2026-06-04 | Buy |
| Activate Scientific | AS110178 | 6-Chloro-5-iodopyridin-2-amine 97% | 1221398-11-3 | 5g | $135 | 2026-06-04 | Buy |
| Activate Scientific | AS110178 | 6-Chloro-5-iodopyridin-2-amine 97% | 1221398-11-3 | 25g | $491 | 2026-06-04 | Buy |
| Matrix Scientific | 070976 | 6-Chloro-5-iodopyridin-2-amine | 1221398-11-3 | 5.00g | $80 | 2026-05-18 | Buy |
6-Chloro-5-iodopyridin-2-aMine Chemical Properties, Uses, Production
Synthesis
45644-21-1
1221398-11-3
The general procedure for the synthesis of 6-chloro-5-iodopyridin-2-amine from 2-amino-6-chloropyridine was as follows: to a solution of N,N-dimethylformamide (DMF, 700 mL) of 2-amino-6-chloropyridine (50.0 g, 389 mmol) was added N-iodosuccinimide (NIS, 105 g, 467 mmol). The reaction mixture was stirred at room temperature for 12 h. The reaction solution was brown in color. After completion of the reaction, the mixture was poured into water (2.1 L) and the precipitate was collected by filtration. The filter cake was washed with water (2 x 500 mL) and subsequently dried under vacuum. Purification by fast column chromatography (FCC, silica gel; 5-20% ethyl acetate/petroleum ether) gave 6-chloro-5-iodopyridin-2-amine (83 g, 75% yield) as a pink solid. Mass spectrum (ESI): calculated value C5H4ClIN2, 253.9; measured value m/z 254.7 [M + H]+. 1H NMR (400 MHz, CDCl3) δ 7.74 (d, J = 8.0 Hz, 1H), 6.20 (d, J = 8.0 Hz, 1H), 4.69 (br s, 2H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 5, p. 1697 - 1700
[2] Patent: US2018/111933, 2018, A1. Location in patent: Paragraph 0243
[3] European Journal of Medicinal Chemistry, 2014, vol. 84, p. 404 - 416
[4] Patent: WO2013/93484, 2013, A1. Location in patent: Page/Page column 243
[5] Patent: WO2016/168098, 2016, A1. Location in patent: Page/Page column 50
6-Chloro-5-iodopyridin-2-aMine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4534 | 58 |
| Xi'an NewProChem Co.,Ltd. | 15332490153 | newprochem@126.com | China | 991 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Nanijing m&m biotechnology Co. ,Ltd. | 025-87782433 18021532344 | 1345332203@qq.com | China | 4226 | 58 |
