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TC ASK 10

TC ASK 10 structure

CAS No.: 1005775-56-3

Chemical Name:: TC ASK 10

Synonyms: TC ASK 10;ASK1 Inhibitor 10;TC ASK 10, 10 mM in DMSO;4-tert-butyl-N-(6-imidazol-1-ylimidazo[1,2-a]pyridin-2-yl)benzamide:hydrochloride;N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-(tert-butyl)benzamide dihydrochloride;4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride;Apoptosis,ASK1,oral,MAP3K,bioavailability,TC ASK-10,TC ASK10,Inhibitor,pharmacokinetic,JNK,TC ASK 10,p38,inhibit,selective,MAP kinase kinase kinase, MEKK, MAPKKK,Phosphorylation

CBNumber:: CB13037545

Molecular Formula:: C21H22ClN5O

Molecular Weight:: 395.89

MDL Number:: MFCD26792581

MOL File:: 1005775-56-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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TC ASK 10 Properties

Melting point	>270° (dec.)
storage temp.	Refrigerator, under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
HS Code	2933998090

TC ASK 10 price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	28512	ASK1 Inhibitor 10 ≥95%	1005775-56-3	1mg	$36	2026-04-30	Buy
Cayman Chemical	28512	ASK1 Inhibitor 10 ≥95%	1005775-56-3	5mg	$145	2026-04-30	Buy
Cayman Chemical	28512	ASK1 Inhibitor 10 ≥95%	1005775-56-3	10mg	$236	2026-04-30	Buy
Cayman Chemical	28512	ASK1 Inhibitor 10 ≥95%	1005775-56-3	25mg	$544	2026-04-30	Buy
Usbiological	256823	TC ASK 10 Asreported	1005775-56-3	10mg	$516	2026-06-03	Buy

Product number	Packaging	Price	Buy
28512	1mg	$36	Buy
28512	5mg	$145	Buy
28512	10mg	$236	Buy
28512	25mg	$544	Buy
256823	10mg	$516	Buy

TC ASK 10 Chemical Properties,Uses,Production

Description

ASK1 inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1; IC₅₀ = 14 nM). It is selective for ASK1 over ASK2 (IC₅₀ = 510 nM) as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF (IC₅₀s = >10,000 nM for all). It inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner.

Uses

TC ASK 10 is a potent ASK1 inhibitor. It displays selectivity for ASK1 over other kinases including ASK2, MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf. It blocks downstream JNK1/p38 phosphorylation in cells.

in vivo

Pharmacokinetic profiles in rats are tested. TC ASK 10 (Compound 10 HCl; rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The C_max, T_max and AUC_po,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10^[1].

IC 50

ASK1: 14 nM (IC₅₀)

storage

Desiccate at RT

References

[1] YOSHITO TERAO. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 24: Pages 7326-7329. DOI: 10.1016/j.bmcl.2012.10.084

TC ASK 10 Preparation Products And Raw materials

Raw materials

Preparation Products

TC ASK 10 Suppliers

Global( 57)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8435	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9699	58
MQ (shanghai) Pharmaceuticals Co., Ltd.	13761635123	sales@linyuepharm.com	China	5731	55
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6288	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30203	58
Shanghai Dongyang Biotechnology Co., Ltd.	0512-13601744364 13601744364	chemsharker@126.com	China	1159	58

Supplier	Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Chaolan Chemical Technology Center	58
MQ (shanghai) Pharmaceuticals Co., Ltd.	55
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Career Henan Chemica Co	58
Shanghai Dongyang Biotechnology Co., Ltd.	58

View Lastest Price from TC ASK 10 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-22	TC ASK 10 1005775-56-3	$29.00-133.00		99.86%	10g	TargetMol Chemicals Inc.
	2026-07-27	TC ASK 10 1005775-56-3	$29.00-133.00		99.86%	10g	TargetMol Chemicals Inc.

TC ASK 10
1005775-56-3
$29.00-133.00
99.86%
TargetMol Chemicals Inc.

TC ASK 10
1005775-56-3
$29.00-133.00
99.86%
TargetMol Chemicals Inc.

TC ASK 10 Spectrum

TC ASK 10(1005775-56-3)¹HNMR

1005775-56-3(TC ASK 10)Related Search:

TC ASK 10 Benzamide, 4-(1,1-dimethylethyl)-N-imidazo[1,2-a]pyridin-2-yl- 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-[2-(hexahydro-1H-azepin-1-yl)ethyl]-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile N-[2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl]biphenyl-4-carboxamide

Tpl2 Kinase Inhibitor (hydrochloride)

1of2

TC ASK 10 ASK1 Inhibitor 10 4-tert-butyl-N-(6-imidazol-1-ylimidazo[1,2-a]pyridin-2-yl)benzamide:hydrochloride 4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride Apoptosis,ASK1,oral,MAP3K,bioavailability,TC ASK-10,TC ASK10,Inhibitor,pharmacokinetic,JNK,TC ASK 10,p38,inhibit,selective,MAP kinase kinase kinase, MEKK, MAPKKK,Phosphorylation N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-(tert-butyl)benzamide dihydrochloride TC ASK 10, 10 mM in DMSO 1005775-56-3 C21H21N5O2HCl